Single-Dose Fluconazole Therapy for Oral Thrush in Hospice and Palliative Medicine Patients

Lagman, Ruth; Davis, Mellar P.; LeGrand, Susan B.; Walsh, Declan; Parala, Armida; Gamier, Pamela; Cothren, Brenda; Cheema, Bushra; Gopal, Sumi; Rybicki, Lisa

doi:10.1177/1049909116643927

Cited by 8 publications

(10 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Functional impact include difficulties in swallowing, speaking and eating, food restriction, sense of oral dryness and pain, which resulted in lack of food enjoyment [5,26,28]. Table 4 presents our findings on the management of some oral conditions among palliative patients and their effectiveness [11,15,17,[19][20][21][22][23] Our study revealed that the common management options for xerostomia are drug and medical treatments [15], lubricating lips and mucosa [17], acupuncture [19], and standard oral care which improved dry mouth (in 80% or more) of the patients [11]. For candidiasis, a single-dose fluconazole 150 mg via mouth was found to be very effective as the symptoms decreased significantly (P < 0.001) in most patients [20], and local antifungal treatments were reported to be efficacious in 78.1% of the patients [23].…”

Section: Common Oral Conditions Among Palliative Patientsmentioning

confidence: 95%

“…Studies reporting on oral conditions among palliative patients are summarized in Table 1. Of the included studies, 16 were quantitative studies [5,[11][12][13][14][15][16][17][18][19][20][21][22][23][24], and 3 were qualitative studies [25][26][27] (Table 2).…”

Section: Characteristics Of Studymentioning

confidence: 99%

“…Out of 19 studies, 13 reported xerostomia or dryness of mouth [5, 11, 14-17, 19, 23-28]. Eight studies reported candidiasis or oral thrush [11,14,16,20,[23][24][25][26]. Six studies reported dysphagia or swallowing difficulties [15, 17-19, 22, 26].…”

Section: Common Oral Conditions Among Palliative Patientsmentioning

confidence: 99%

“…Table 4 presents our findings on the management of some oral conditions among palliative patients and their effectiveness [11,15,17,[19][20][21][22][23] Our study revealed that the common management options for xerostomia are drug and medical treatments [15], lubricating lips and mucosa [17], acupuncture [19], and standard oral care which improved dry mouth (in 80% or more) of the patients [11]. For candidiasis, a single-dose fluconazole 150 mg via mouth was found to be very effective as the symptoms decreased significantly (P < 0.001) in most patients [20], and local antifungal treatments were reported to be efficacious in 78.1% of the patients [23]. A substantial improvement of dysphagia was also observed after fifth treatment of acupuncture [19], however, its management using step-based pharmacological intervention and topically acting drugs caused worsening of swallowing and soreness of mouth [22].…”

Section: Common Oral Conditions Among Palliative Patientsmentioning

confidence: 99%

See 3 more Smart Citations

Oral health problems among palliative and terminally ill patients: an integrated systematic review

et al. 2020

View full text Add to dashboard Cite

Background: High incidence of treatable oral conditions has been reported among palliative patients. However, a large proportion of palliative patients lose their ability to communicate their sufferings. Therefore, it may lead to under-reporting of oral conditions among these patients. This review systematically synthesized the published evidence on the presence of oral conditions among palliative patients, the impact, management, and challenges in treating these conditions. Methods: An integrative review was undertaken with defined search strategy from five databases and manual search through key journals and reference list. Studies which focused on oral conditions of palliative patients and published between years 2000 to 2017 were included. Results: Xerostomia, oral candidiasis and dysphagia were the three most common oral conditions among palliative patients, followed by mucositis, orofacial pain, taste change and ulceration. We also found social and functional impact of having certain oral conditions among these patients. In terms of management, complementary therapies such as acupuncture has been used but not well explored. The lack of knowledge among healthcare providers also posed as a challenge in treating oral conditions among palliative patients. Conclusions: This review is first in its kind to systematically synthesize the published evidence regarding the impact, management and challenges in managing oral conditions among palliative patients. Although there is still lack of study investigating palliative oral care among specific group of patients such as patients with dementia, geriatric or pediatric advanced cancer patients, this review has however provided baseline knowledge that may guide health care professionals in palliative settings.

show abstract

Section: Common Oral Conditions Among Palliative Patientsmentioning

confidence: 95%

Section: Characteristics Of Studymentioning

confidence: 99%

Section: Common Oral Conditions Among Palliative Patientsmentioning

confidence: 99%

Section: Common Oral Conditions Among Palliative Patientsmentioning

confidence: 99%

See 2 more Smart Citations

Oral health problems among palliative and terminally ill patients: an integrated systematic review

et al. 2020

View full text Add to dashboard Cite

show abstract

“…contact with lesions) and (g) patient adherence. (Currently, there is no robust evidence to support the use of single doses of fluconazole in this condition [81] (no guideline possible)).…”

Section: Managementmentioning

confidence: 99%

MASCC/ISOO expert opinion on the management of oral problems in patients with advanced cancer

Jones

Chávarri‐Guerra

Corrêa

et al. 2022

Support Care Cancer

View full text Add to dashboard Cite

Purpose The Palliative Care Study Group in conjunction with the Oral Care Study Group of the Multinational Association for Supportive Care in Cancer (MASCC) formed a sub-group to develop evidence-based guidance on the management of common oral problems in patients with advanced cancer. Methods This guidance was developed in accordance with the MASCC Guidelines Policy. A search strategy for Medline was developed, and the Cochrane Database of Systematic Reviews and the Cochrane Central Register of Controlled Trials were explored for relevant reviews and trials, respectively. Guidance was categorised by the level of evidence, and “category of guideline” (i.e., “recommendation”, “suggestion” or “no guideline possible”). Results Twelve generic suggestions (level of evidence – 5), three problem-specific recommendations and 14 problem-specific suggestions were generated. The generic suggestions relate to oral hygiene measures, assessment of problems, principles of management, re-assessment of problems and the role of dental/oral medicine professionals. Conclusions This guidance provides a framework for the management of common oral problems in patients with advanced cancer, although every patient requires individualised management.

show abstract

Palliative and Supportive Medicine in Gastrointestinal Oncology

Berninger,

Tapper,

Browner

et al. 2024

Gastrointestinal Oncology ‐ a Critical Multidisciplinary Team Approach 2e

View full text Add to dashboard Cite

Single-Dose Fluconazole Therapy for Oral Thrush in Hospice and Palliative Medicine Patients

Abstract: Single-dose fluconazole 150 mg is an effective treatment of oral thrush for individuals with advanced cancer.

Cited by 8 publications

References 20 publications

Oral health problems among palliative and terminally ill patients: an integrated systematic review

Oral health problems among palliative and terminally ill patients: an integrated systematic review

MASCC/ISOO expert opinion on the management of oral problems in patients with advanced cancer

Palliative and Supportive Medicine in Gastrointestinal Oncology

Contact Info

Product

Resources

About