Single-Dose Montelukast or Salmeterol as Protection Against Exercise-Induced Bronchoconstriction

Philip, George; Pearlman, David S.; Villarán, César; Legrand, Catherine; Loeys, Tom; Langdon, Ronald B.; Reiss, Theodore F.

doi:10.1378/chest.07-0550

Cited by 41 publications

(33 citation statements)

References 38 publications

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“…Trials of montelukast have provided variable results [45][46][47][48]. In one trial, montelukast provided measurable protection against EIB in asthma patients 15 to 44 years of age, with onset of action within 2 hours [46].…”

Section: Therapymentioning

confidence: 99%

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An update on exercise-induced bronchoconstriction with and without asthma

Randolph

2009

Curr Allergy Asthma Rep

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Exercise-induced bronchoconstriction (EIB) is defined as transient, reversible bronchoconstriction that develops after strenuous exercise. It is a heterogeneous syndrome made up of a spectrum of phenotypes ranging from the asymptomatic military recruit whose condition is detected by diagnostic exercise challenge to the athlete with known asthma to the elite athlete for whom EIB represents an overuse or injury syndrome. If exercise is the only identified trigger for bronchoconstriction, it is called EIB. However, when it is associated with known asthma, then it is defined as EIB with asthma. This review discusses the pathogenesis, presentation, diagnosis, and management of EIB and EIB with asthma.

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Section: Therapymentioning

confidence: 99%

“…Tolerance occurs to the duration of protection from EIB and was not prevented through use of inhaled corticosteroids [45][46][47]. LABAs are thus recommended only as needed, preferably three or four times per week [29•].…”

Section: Therapymentioning

confidence: 99%

An update on exercise-induced bronchoconstriction with and without asthma

Randolph

2009

Curr Allergy Asthma Rep

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“…This is not readily predictable but such patients may include those with significant inflammation of the upper airways, as occurs with allergic rhinitis or nasal polyposis, 43 those with sensitivity to acetylsalicylic acid 44 and perhaps those with significant exercise-induced bronchoconstriction. 45 However, these responses are not consistent, and a trial of one medication, followed by a trial of the other if the first one fails, is a common approach.…”

Section: Which Is the Best Therapy To Add To Inhaled Corticosteroids?mentioning

confidence: 99%

Management of asthma in adults

Balter¹,

Bell²,

Kaplan³

et al. 2009

Canadian Medical Association Journal

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“…Indeed, in three placebo-controlled studies of montelukast in EIB, which required patients to demonstrate ≥20% fall in forced expiratory volume in one second (FEV 1 ) on two separate screening visits, the mean maximum percentage fall postchallenge was ∼28% before receiving treatment. However, during the treatment periods, the maximum percentage fall postchallenge after receiving placebo treatment was approximately 22% in two studies (22,23), and only 17% in one study (24). Similarly, there were sizeable spontaneous improvements in time to recovery and area under the curve (AUC) for maximum percentage fall in FEV 1 after placebo treatment.…”

Section: Introductionmentioning

confidence: 95%

“…Therefore, the purpose of this analysis was to further evaluate both the variability of placebo response in EIB, as well as the relationship between demographic and disease characteristics and the response to placebo using data pooled from three similarly designed placebo-controlled trials of montelukast in EIB (22)(23)(24).…”

Section: Introductionmentioning

confidence: 99%