Single Dose of Anti-Transforming Growth Factor-β1 Monoclonal Antibody Enhances Liver Regeneration After Partial Hepatectomy in Biliary-Obstructed Rats

Deneme, Mehmet Ali; Ok, Engin; Akçan, Alper; Soyuer, Işın; Muhtaroğlu, Sebahattin

doi:10.1016/j.jss.2006.08.020

Cited by 15 publications

(14 citation statements)

References 36 publications

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“…The results of the presented study confirmed in large animal experiment previous findings gained using in vitro models and in experiments with small laboratory animals (Armendariz-Borunda, 1993, Armendariz-Borunda, 1997, Deneme, 2006, Delgado-Rizo, 1998. The selected concentration and timing of the application of monoclonal antibody prolonged acceleration of liver parenchyma regeneration in non-occluded liver lobes of animals (Armendariz-Borunda, 1993, Deneme, 2006. The secondary effects that could be hypothesized after application of the monoclonal antibody against key pleiotropic growth factor (changes in immune reactions and homeostasis) were not observed either during application or in the whole postoperative period.…”

Section: Functional Liver Remnant Volumesupporting

confidence: 89%

“…Nevertheless this growth accelerating effect was lost during the next ultrasonographic controls, and on the 14 th postoperative day there were no statistically significant differences. The results of the presented study confirmed in large animal experiment previous findings gained using in vitro models and in experiments with small laboratory animals (Armendariz-Borunda, 1993, Armendariz-Borunda, 1997, Deneme, 2006, Delgado-Rizo, 1998. The selected concentration and timing of the application of monoclonal antibody prolonged acceleration of liver parenchyma regeneration in non-occluded liver lobes of animals (Armendariz-Borunda, 1993, Deneme, 2006.…”

Section: Functional Liver Remnant Volumesupporting

confidence: 85%

“…Administration of MAB TGF-1 was performed into central venous catheter 24 hours after ligation (7 piglets, 40μg/kg of body weight) ( Armendariz-Borunda , 1993, Deneme, 2006. …”

Section: Surgical Proceduresmentioning

confidence: 99%

See 2 more Smart Citations

Liver Parenchyma Regeneration in Connection with Extended Surgical Procedure - Experiment on Large Animal

Liška¹,

Třeška²,

Mírka³

et al. 2012

Liver Regeneration

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Section: Functional Liver Remnant Volumesupporting

confidence: 89%

Section: Functional Liver Remnant Volumesupporting

confidence: 85%

See 1 more Smart Citation

Liver Parenchyma Regeneration in Connection with Extended Surgical Procedure - Experiment on Large Animal

Liška¹,

Třeška²,

Mírka³

et al. 2012

Liver Regeneration

View full text Add to dashboard Cite

“…Furthermore, in the same model adenoviral transfection resulted in a cessation in the progression of liver fibrosis even after it had already been established and enhanced hepatocyte regeneration [22]. Similarly, a single dose of anti-TGF-␤ antibody enhanced liver regeneration in partial hepatectomized rats after bile duct ligation [23]. Inhibition of TGF-␤ function using a soluble Type 2 receptor prevented hepatic fibrosis in a bile duct ligation model, suggesting that the same therapy may be useful in a biliary atresia model [24].…”

Section: Discussionmentioning

confidence: 96%

Integrin αvβ6 and Mediators of Extracellular Matrix Deposition Are Up-Regulated in Experimental Biliary Atresia

Nadler

Patterson

Violette

et al. 2009

Journal of Surgical Research

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“…Vice versa, it is reported that KC inactivation during liver repair impairs collagen metabolism, inhibits the resolution of fibrosis, and supports the persistence of inflammatory cell infiltrates (685). These repair processes are crucially dependent on the balance of growth factors in aid of HGF (146,513,580,928). In addition, depletion of KC in the regenerating liver alters the pattern of vasoregulatory gene expression, thereby limiting intrahepatic hyperperfusion as an important trigger of proliferation (5).…”

Section: A Role Of Platelets Leukocytes and Kupffer Cellsmentioning

confidence: 99%

The Hepatic Microcirculation: Mechanistic Contributions and Therapeutic Targets in Liver Injury and Repair

Vollmar

Menger²

2009

Physiological Reviews

433

368

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The complex functions of the liver in biosynthesis, metabolism, clearance, and host defense are tightly dependent on an adequate microcirculation. To guarantee hepatic homeostasis, this requires not only a sufficient nutritive perfusion and oxygen supply, but also a balanced vasomotor control and an appropriate cell-cell communication. Deteriorations of the hepatic homeostasis, as observed in ischemia/reperfusion, cold preservation and transplantation, septic organ failure, and hepatic resection-induced hyperperfusion, are associated with a high morbidity and mortality. During the last two decades, experimental studies have demonstrated that microcirculatory disorders are determinants for organ failure in these disease states. Disorders include 1) a dysregulation of the vasomotor control with a deterioration of the endothelin-nitric oxide balance, an arterial and sinusoidal constriction, and a shutdown of the microcirculation as well as 2) an overwhelming inflammatory response with microvascular leukocyte accumulation, platelet adherence, and Kupffer cell activation. Within the sequelae of events, proinflammatory mediators, such as reactive oxygen species and tumor necrosis factor-alpha, are the key players, causing the microvascular dysfunction and perfusion failure. This review covers the morphological and functional characterization of the hepatic microcirculation, the mechanistic contributions in surgical disease states, and the therapeutic targets to attenuate tissue injury and organ dysfunction. It also indicates future directions to translate the knowledge achieved from experimental studies into clinical practice. By this, the use of the recently introduced techniques to monitor the hepatic microcirculation in humans, such as near-infrared spectroscopy or orthogonal polarized spectral imaging, may allow an early initiation of treatment, which should benefit the final outcome of these critically ill patients.

show abstract

Single Dose of Anti-Transforming Growth Factor-β1 Monoclonal Antibody Enhances Liver Regeneration After Partial Hepatectomy in Biliary-Obstructed Rats

Cited by 15 publications

References 36 publications

Liver Parenchyma Regeneration in Connection with Extended Surgical Procedure - Experiment on Large Animal

Liver Parenchyma Regeneration in Connection with Extended Surgical Procedure - Experiment on Large Animal

Integrin αvβ6 and Mediators of Extracellular Matrix Deposition Are Up-Regulated in Experimental Biliary Atresia

The Hepatic Microcirculation: Mechanistic Contributions and Therapeutic Targets in Liver Injury and Repair

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