Single Dose of Two Grams of Metronidazole for Trichomonas Vaginalis Infection

Fleury, Frederick J.; Bergen, William S. Van; Prentice, Robert L.; Russell, James; Singleton, James A.; Standard, John V.

doi:10.1097/00006254-197710000-00022

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…dosage [2,6], The nimorazole 2-gram dosage has been stan dard therapy in the St. Mary's unit for some years. Using such an initial treatment provides an ideal way of investigating the value of the vaccine in preventing reinfection in susceptible female patients.…”

Section: Discussionmentioning

confidence: 99%

Double-Blind Comparative Study of Trichomonas vaginalis Infection: SolcoTrichovac versus Placebo

Harris¹

1984

Gynäkol Geburtshilfliche Rundsch

View full text Add to dashboard Cite

Two hundred patients suffering from vaginal Trichomonas vaginalis infection were admitted to a double-blind clinical study. All patients provided a detailed history of previous episodes of vaginitis. All women were treated with one dose of nimorazole 2 g stat. In addition, one group of patients were vaccinated with SolcoTrichovac and the other group received a placebo ‘vaccination’. The immediate effect of the nimorazole treatment was comparable in both groups, relapses and reinfections, however, differed significantly after 4 weeks (p < 0.01) in favour of the SolcoTrichovac group. After 4 and 8 months, the effect of the vaccine in preventing reinfections was even more pronounced, with a statistical difference of p < 0.001 between the two groups of patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Double-Blind Comparative Study of Trichomonas vaginalis Infection: SolcoTrichovac versus Placebo

Harris¹

1984

Gynäkol Geburtshilfliche Rundsch

View full text Add to dashboard Cite

show abstract

“…Studies on drug disposition in cervical mucus are important for at least two reasons. Firstly drugs may exert their therapeutic action through their concentration in the genital tract, for example metronidazole in the treatment of Trichomonas infections (Fleury et al 1977). Secondly, drugs may exert unwanted effects, for example reducing sperm motility and fertility.…”

Section: London Ecla 7be Ukmentioning

confidence: 99%

Concentration of ibuprofen in cervical mucus

Salas-Herrera

Pearson

Turner

1991

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

Concentrations of an acidic drug, ibuprofen, in cervical mucus and serum have been measured by HPLC after oral administration in six healthy volunteers. After an 800 mg single dose of ibuprofen, the concentration reached in cervical mucus was less than 4% of that in serum. It is postulated that because ibuprofen is an acidic drug which is not subject to 'ion-trapping' in the acidic environment of cervical mucus, it is not concentrated in this secretion.

show abstract

Single Dose of Two Grams of Metronidazole for Trichomonas Vaginalis Infection

Cited by 2 publications

References 0 publications

Double-Blind Comparative Study of Trichomonas vaginalis Infection: SolcoTrichovac versus Placebo

Double-Blind Comparative Study of Trichomonas vaginalis Infection: SolcoTrichovac versus Placebo

Concentration of ibuprofen in cervical mucus

Contact Info

Product

Resources

About