Single dose oral flurbiprofen for acute postoperative pain in adults

Sultan, Asquad; McQuay, Henry J; Moore, R Andrew; Derry, Sheena

doi:10.1002/14651858.cd007358.pub2

Cited by 19 publications

(8 citation statements)

References 60 publications

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“…The effectiveness of flurbiprofen or NSAIDs in acute postoperative pain has been demonstrated by a previous systematic review paper [7, 8], and our results are consistent with this.…”

Section: Discussionsupporting

confidence: 93%

“…In this study, flurbiprofen was used in 96 out of 112 cases, indicating that it plays a major role in pain management after extraction of wisdom teeth under general anesthesia in patients with intellectual disabilities in our facility. The effectiveness of flurbiprofen or NSAIDs in acute postoperative pain has been demonstrated by a previous systematic review paper [ 7 , 8 ], and our results are consistent with this.…”

Section: Discussionsupporting

confidence: 93%

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Clinical Analysis of Analgesics and Steroids Use for Extraction of Teeth in Patients with Intellectual Disability Under General Anesthesia

Miyagawa

Honda

Tanimura

et al. 2017

TODENTJ

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Background:The extraction of lower wisdom teeth is often performed under general anesthesia in patients with intellectual disabilities. However, the choice of analgesics has not yet been investigated.Objective:To analyze the use of analgesics during general anesthesia for extraction including lower wisdom teeth in patients with intellectual disabilities.Methods:This research is a retrospective observational study. The study population was composed of all patients presenting for extraction of lower wisdom teeth under ambulatory general anesthesia in the clinic of Special Needs Dentistry in Okayama University Hospital from April 2011 to March 2016. The distribution of the combination of analgesics and the relationship between the use of analgesics and the type of extraction were investigated.Results:One hundred and twelve cases were enrolled in this study. Intravenous injections of flurbiprofen, acetaminophen and betamethasone were used in 96 (85.7%), 12 (10.7%) and 26 cases (23.2%), respectively. Flurbiprofen is a non-steroid anti-inflammatory drugs (NSAIDs). Acetaminophen is an old analgesic, but an injection of acetaminophen is new, which was released in 2013 in Japan. And betamethasone is not an analgesic, but a steroid. Betamethasone was used in combination with other analgesics, and was used at a higher dose in a case in which four wisdom teeth were extracted.Conclusion:Flurbiprofen was the main analgesic used for extraction of wisdom teeth under general anesthesia in patients with intellectual disabilities. Betamethasone was used to support flurbiprofen or acetaminophen for extractions of multiple wisdom teeth, with the aim of controlling swelling rather than relieving pain.

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“…The effectiveness of flurbiprofen or NSAIDs in acute postoperative pain has been demonstrated by a previous systematic review paper [7, 8], and our results are consistent with this.…”

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

Clinical Analysis of Analgesics and Steroids Use for Extraction of Teeth in Patients with Intellectual Disability Under General Anesthesia

Miyagawa

Honda

Tanimura

et al. 2017

TODENTJ

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“…Flurbiprofen is a nonselective cyclooxygenase (COX) inhibitor used clinically as an NSAID [ 24 ]. NSAIDs such as flurbiprofen are prescribed largely for their anti-inflammatory, antipyretic, and analgesic properties.…”

Section: Discussionmentioning

confidence: 99%

Flurbiprofen axetil attenuates cerebral ischemia/reperfusion injury by reducing inflammation in a rat model of transient global cerebral ischemia/reperfusion

Tang

Tai

et al. 2018

Bioscience Reports

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“…Flurbiprofen is a non-selective COX inhibitor that is clinically used as an NSAID ( 19 ). It is mainly used for its anti-inflammatory, antipyretic, and analgesic effects.…”

Section: Discussionmentioning

confidence: 99%

Flurbiprofen axetil alleviates the effect of formalin-induced inflammatory pain on the cognitive function of rats with mild cognitive impairment through the AMPKα/NF-κB signaling pathway

Huang¹,

Zheng²,

Zhang³

et al. 2022

Ann Transl Med

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Background: Mild cognitive impairment (MCI) as a prestage of dementia shares the most risk factors with dementia. In the present study, we explored the effect of flurbiprofen axetil on reducing the response of the central nervous system to inflammatory factors and anti-inhibiting apoptosis with the aim of developing a formalin-induced inflammatory pain model using MCI rats.Methods: Rats were subjected to sham operation (Sham group) or formalin-induced inflammatory pain, with or without flurbiprofen axetil (10 mg/kg). MCI rats were administered D-galactose (1,000 mg/kg) for 7 days subcutaneously. Thereafter, formalin was injected subcutaneously into the hind paws of rats, while sham group was injected with only normal saline. In the formalin/flurbiprofen group (F/F group), flurbiprofen axetil was injected into the tail vein 15 min before formalin was given, and the formalin/saline group (F/S group) used normal saline instead of the drug for injection. The pain score was recorded, and the time-score curve was drawn. The escape latency time and the number of times crossing the platform were recorded. The expression of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), AMP-activated protein kinase-α (AMPKα), and nuclear factor-κB p65 (NF-κB p65) in hippocampal tissue was determined. Varying degrees of pathological changes in the hippocampal CA1 region were observed. Results:The II phase pain score of rats in the F/F group was lower than that of the F/S group rats (P<0.05).The evasion incubation period and the number of platform crossings increased in both the F/F group and the F/S group (P<0.05), and were more significant in the F/S group. The relative content of AMPKα increased sequentially in the 3 groups, and the difference between the two comparisons of each group was statistically significant (P<0.05). The relative content of IL-6, TNF-α and NF-κB in the F/S group was greater than that of the F/F group, and the difference was statistically significant (P<0.001). Pathological morphological observations can be seen that the phenomena of nuclear consolidation, deep staining, and neuronal apoptosis occur, and the F/S group is more obvious. Conclusions:Flurbiprofen axetil can reduce the inflammatory response and cognitive function of an inflammatory pain model using MCI rats through the AMPKα/NF-κB signaling pathway.

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Single dose oral flurbiprofen for acute postoperative pain in adults

Abstract: Background-Flurbiprofen is a non-selective non-steroidal anti-inflammatory drug (NSAID), related to ibuprofen and naproxen, used to treat acute and chronic painful conditions. There is no systematic review of its use in acute postoperative pain.

Cited by 19 publications

References 60 publications

Clinical Analysis of Analgesics and Steroids Use for Extraction of Teeth in Patients with Intellectual Disability Under General Anesthesia

Clinical Analysis of Analgesics and Steroids Use for Extraction of Teeth in Patients with Intellectual Disability Under General Anesthesia

Flurbiprofen axetil attenuates cerebral ischemia/reperfusion injury by reducing inflammation in a rat model of transient global cerebral ischemia/reperfusion

Flurbiprofen axetil alleviates the effect of formalin-induced inflammatory pain on the cognitive function of rats with mild cognitive impairment through the AMPKα/NF-κB signaling pathway

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