Single‐dose oral omeprazole for reduction of gastric residual acidity in adults for outpatient surgery

Abstract

Omeprazole is a substituted benzimidazole that causes dose-dependent intracellular inhibition of gastric acid secretion in humans. This double-blind study examined the effect of omeprazole in decreasing gastric acidity and gastric residual volume in outpatient adults. Unpremedicated outpatients, ASA I-III, 18 years or older (n = 17), were randomly assigned to receive omeprazole 80 mg, or placebo by mouth the night before scheduled elective outpatient surgery. The patients were fasted for 8 h prior to surgery. After the patient was anesthetized, an orogastric tube was inserted with proper placement verified by auscultation for gastric sounds. Gastric residual contents were withdrawn into a Luken's trap, and pH was then determined and gastric volume indexed to weight (ml.kg-1). Data were analyzed by a t-test, with P less than 0.05 considered statistically significant. Patient characteristics of both groups were similar. There was a statistically significant difference between the two groups for pH (P = 0.02), but not between the two groups for gastric volume indexed to weight (P = 0.07).

Perioperative fasting and feeding in adults, obstetric, paediatric and bariatric population: Practice Guidelines from the Indian Society of Anaesthesiologists

“…The meta-analysis of 3 studies comparing residual gastric volumes after administration of proton pump inhibitors and placebo yielded a mean difference of 3.31 mL with a 95% CI of +2.34 to 4.68 (LOE- Moderate). [ 101 102 103 ] Mehta et al . conducted a study comparing three different proton pump inhibitors and found that the residual gastric volumes were comparable among them (LOE- Very Low).…”