Single‐dose pharmacokinetics of oxytetracycline and penicillin G in tammar wallabies (<i>Macropus eugenii</i>)

McLelland, David J.; Barker, Ian K.; Crawshaw, Graham J.; Hinds, Lyn A.; Spilsbury, L.; Johnson, Ron J.

doi:10.1111/j.1365-2885.2010.01216.x

Cited by 4 publications

(2 citation statements)

References 36 publications

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“…The linearity of the calibration curve of the analytical method is excellent with regression coefficient > 0.999, and all the samples measured in this study were above the LOQ. The pharmacokinetics of OTC in this study was performed using a non-compartmental model (25,26). Its simplicity, objectivity, and practicability favor its use for description of the time course of drug concentrations in the body (17,27).…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of Free Oxytetracycline and Oxytetracycline Loaded Cockle Shell Calcium Carbonate-Based Nanoparticle in BALB/c Mice

et al. 2020

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The development and utilization of nano-antibiotics is currently gaining attention as a possible solution to antibiotic resistance. The aim of this study was therefore to determine the pharmacokinetics of free oxytetracycline (OTC) and oxytetracycline loaded cockle shell calcium carbonate-based nanoparticle (OTC-CNP) after a single dose of intraperitoneal (IP) administration in BALB/c mice. A total of 100 female BALB/c mice divided into two groups of equal number (n = 50) were administered with 10 mg/kg OTC and OTC-CNP, respectively. Blood samples were collected before and post-administration from both groups at time 0, 5, 10, 15, and 30 min and 1, 2, 6, 24, and 48 h, and OTC plasma concentration was quantified using a validated HPLC-UV method. The pharmacokinetic parameters were analyzed using a non-compartment model. The C max values of OTC in OTC-CNP and free OTC treated group were 64.99 and 23.53 µg/ml, respectively. OTC was detected up to 24 h in the OTC-CNP group as against 1 h in the free OTC group following intraperitoneal administration. In the OTC-CNP group, the plasma elimination rate of OTC was slower while the half-life, the area under the curve, and the volume of the distribution were increased. In conclusion, the pharmacokinetic profile of OTC in the OTC-CNP group differs significantly from that of free OTC. However, further studies are necessary to determine the antibacterial efficacy of OTC-CNP for the treatment of bacterial diseases.

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Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of Free Oxytetracycline and Oxytetracycline Loaded Cockle Shell Calcium Carbonate-Based Nanoparticle in BALB/c Mice

et al. 2020

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“…This advantage is (Kumar and Malik, 1998), goats (Aktas and Yarsan, 2017), pigs (El Korchi et al, 2001) and buffaloes (Poapolathep et al, 2017). Moreover, the PK studies of OTC-LA were expanded to some wildlife, tammar wallabies (McLelland et al, 2011) and reptiles such as American alligators (Helmick et al, 2004) and freshwater crocodiles (Poapolathep et al, 2020).…”

Section: Long-acting Formulations Of Otc (Otc-la)mentioning

confidence: 99%

Pharmacokinetics, pharmacodynamics and dosing regimen of long-acting oxytetracycline in nile tilapia (Oreochromis niloticus)

Vasuntrarak¹

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Antimicrobial resistance has become a serious global problem and is steadily increasing worldwide. In aquaculture, there are limited antimicrobial options for treatment. Thus, there are growing needs for more specific dosing regimens of existing antimicrobial drugs that are not only to obtain therapeutic efficacy but also to minimize the resistance of pathogens. The purposes of this study were to determine pharmacokinetics (PK) of long-acting oxytetracycline (OTC) after intraperitoneal (IP) administration in Nile tilapia. One hundred and twenty healthy male tilapia (450±37.47 g) were divided into two experimental groups (60 fish/group). Each group received OTC-LA single IP injection at dosage of 50 mg/kg or 100 mg/kg bodyweight. Blood samples were collected at various times post-dosing and plasma OTC were analyzed using high performance liquid chromatography (HPLC). For pharmacodynamics (PD) study, 56 S. agalactiae isolates from diseased tilapia were determined for minimum inhibitory concentration (MIC) and mutant prevention concentration (MPC) by agar dilution method. The results showed that the Cmax and Tmax of OTC were 110.70 ± 5.61 µg/ml at 2 h for the dosage of 50 mg/kg, and 287.85 ± 8.03 µg/ml at 4 h for the dosage of 100 mg/kg. OTC level in plasma was slowly depleted and remained at 3.99 ± 0.48 µg/ml and 23.00 ± 2.51 µg/ml at 168 h (7 day) after administration OTC-LA at the dosages of 50 and 100 mg/kg, respectively. From 56 S. agalactiae samples, MIC range was 0.5 to 2 µg/ml, with MIC50 and MIC90 at 0.5 µg/ml and 1 µg/ml, respectively. MPC range was 4 to 512 µg/ml, with MPC50 and MPC90 at 32 µg/ml and 128 µg/ml, respectively. For the ratio of MPC and MIC and mutant selection window (MSW) results, MPC50/MIC50 ratio was 64 (MSW: 0.5 - 32 µg/ml) and MPC90/MIC90 ratio was 128 (MSW: 1 -128 µg/ml). From the integrated PK/PD parameters, both OTC-LA at the dosages of 50 mg/kg and 100 mg/kg dosages achieved the target values and provided plasma OTC level above MIC for at least 7 days. While PK/PD parameters based on MPC, only OTC-LA at 100 mg/kg dosage can prevent the resistant-mutant subpopulation. Therefore, OTC-LA treatment at 100 mg/kg bodyweight IP administration would be suggested as the optimal dosing regimen to attain therapeutic efficacy and prevent the emergence of resistant-mutant subpopulation and possible to be used as a single administration for the infection caused by S. agalactiae.

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Marsupials

2019

Zoo and Wild Mammal Formulary

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Single‐dose pharmacokinetics of oxytetracycline and penicillin G in tammar wallabies (Macropus eugenii)

Cited by 4 publications

References 36 publications

Pharmacokinetics of Free Oxytetracycline and Oxytetracycline Loaded Cockle Shell Calcium Carbonate-Based Nanoparticle in BALB/c Mice

Pharmacokinetics of Free Oxytetracycline and Oxytetracycline Loaded Cockle Shell Calcium Carbonate-Based Nanoparticle in BALB/c Mice

Pharmacokinetics, pharmacodynamics and dosing regimen of long-acting oxytetracycline in nile tilapia (Oreochromis niloticus)

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