Single‐drop microextraction followed by in‐syringe derivatization and GC‐MS detection for the determination of parabens in water and cosmetic products

Saraji, Mohammad; Mirmahdieh, Shiva

doi:10.1002/jssc.200800635

Cited by 92 publications

(49 citation statements)

References 33 publications

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“…Moreso the derivatization process takes a shorter time at room temperature. Saraji and Mirmahdieh, (2009) studied the influence of different parameters on the in-syringe derivatization process using BSA were three parameters, the amount of the BSA, the reaction time and the reaction temperature were investigated to achieve the highest derivatization reaction yield. The results showed that 0.2 µL volume of BSA derivatization reagent is enough to obtain the maximum derivatization reaction yield for all compounds in 2 min time at room temperature.…”

Section: Bis(trimethylsilyl)-acetamide (Bsa)mentioning

confidence: 99%

Derivatization Reactions and Reagents for Gas Chromatography Analysis

Orata¹

2012

Advanced Gas Chromatography - Progress in Agricultural, Biomedical and Industrial Applications

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Section: Bis(trimethylsilyl)-acetamide (Bsa)mentioning

confidence: 99%

Derivatization Reactions and Reagents for Gas Chromatography Analysis

Orata¹

2012

Advanced Gas Chromatography - Progress in Agricultural, Biomedical and Industrial Applications

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“…This relationship indicates that SDME quantification is feasible before reaching partition equilibrium once the SDME conditions and the extraction time are held constant. 26,27 An extraction time of 25 min was selected as a compromise between the analyte response and the time of analysis.…”

Section: Optimization Of the Microextraction With In Situ Derivatizationmentioning

confidence: 99%

Determination of acidic herbicides in water samples by in situ derivatization, single drop microextraction and gas chromatography-mass spectrometry

Araujo¹,

Prieto²,

Troconis³

et al. 2011

J. Braz. Chem. Soc.

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Um método para a determinação de quantidades traços de herbicidas ácidos em amostras de água foi desenvolvido. O procedimento analítico envolve derivatização in situ dos analitos para seus ésteres metílicos com sulfato de dimetilo, amostragem usando microextração com única gota (SDME) e cromatografia gasosa-espectrometria de massa (GC-MS). Os efeitos do pH, força iônica, tempo de extração, solvente de extração assim como condições de derivatização foram estudados. Ésteres metílicos foram extraídos com 2 µL de n-heptano. A resposta foi linearmente dependente da concentração na faixa de 0,05-10,0 ng mL . A análise por derivatização-SDME/GC-MS rendeu boa precisão (RSD entre 7,0 e 15,2%). O método foi validado pela análise de amostras enriquecidas.A method for the determination of trace amounts of acidic herbicides in water samples was developed. The analytical procedure involves in situ derivatization of analytes to their methyl esters with dimethyl sulfate, sampling using single drop microextraction (SDME) and gas chromatography-mass spectrometry (GC-MS). The effects of pH, ionic strength, extraction time, solvent of extraction as well as derivatization conditions were studied. Methyl esters were extracted using 2 µL of n-heptane. The response was linearly dependent on the concentration in the range 0.05-10.0 ng mL -1 . Limits of detection were achieved at the level of 1.8-3.0 ng L -1 . Derivatization-SDME/GC-MS analysis yielded good precision (RSD between 7.0 and 15.2%). The method was validated by analysis of spiked matrix samples.

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“…Contradictory opinions on the toxicity and carcinogenicity of parabens [3] According to the literature, methods for preconcentration of parabens, which are based on the singl-drop liquid microextraction combines with silylation [5], the dispersion liquid-liquid microextraction (DLLME) without [6] or with derivatization by acetic anhydride [7], followed by chromatographic determination are known.…”

Section: Introductionmentioning

confidence: 99%

Gas Chromatographic determination of parabens after derivatization and dispersive microextraction

Levchyk

Zui

2015

Fr. Ukr. J. Chem.

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Abstract. In this study a dispersive liquid-liquid microextraction method combines with in situ derivatization. The proposed method was used for the extraction and preconcentration of some preservatives including methylparaben, ethylparaben, propylparaben and butylparaben from water matrices. The extracted compounds were determined by gas chromatography -flame ionization detector. Derivatization of parabens was carried out using propionic anhydride. The effects of the extraction solvent type, extraction and acylation time, derivative agent's volume, temperature, pH and ionic strength of solution on the extraction efficiency were investigated. 50 L of chloroform and 500 L of acetonitrile was applied as a mixture of suitable extraction and dispersive solvents.The mixture is centrifuged for 3 min at 4000 rpm. 20 L of propionic anhydride is used for the derivatization of parabens in the concentration range of 0.05 -1 mg L -1 within 2 -3 minutes. The optimum pH range was 8,0 -9,0. The limits of detection (LOD) were 0,003 mg/L for methyl-, ethylparabens; 0,002 mg/L for propyl-, butylparabens, relative standard deviations (RSDs) were in the range of 2.0-10.0 % (n = 3, P = 95 %). The method was applied to the analysis of the four parabens in water. For the analysis of the spiked samples, the recovery above 100 % was obtained.

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Single‐drop microextraction followed by in‐syringe derivatization and GC‐MS detection for the determination of parabens in water and cosmetic products

Cited by 92 publications

References 33 publications

Derivatization Reactions and Reagents for Gas Chromatography Analysis

Derivatization Reactions and Reagents for Gas Chromatography Analysis

Determination of acidic herbicides in water samples by in situ derivatization, single drop microextraction and gas chromatography-mass spectrometry

Gas Chromatographic determination of parabens after derivatization and dispersive microextraction

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