Single droplets to particles - size, shape, shell thickness and porosity analyses using X-ray computed tomography

Abdullahi, Hassan; Neoptolemou, Petros; Burcham, Christopher L.; Vetter, Thomas

doi:10.1016/j.ces.2021.116879

Cited by 9 publications

(4 citation statements)

References 74 publications

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“…Such cavitation events have been observed for spray drying of food material droplets. 1,4,[63][64][65][66] In other cases, the relaxation times t remain within the time scale of drying t { t e , allowing stresses to relax away. If T g /T 4 1.1, the relaxation time of the skin becomes t/t e c 10 3 , meaning that it has become purely elastic.…”

Section: Resultsmentioning

confidence: 99%

Pore development in viscoelastic foods during drying

van der Sman,

Curatolo,

Teresi

2024

Soft Matter

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Section: Resultsmentioning

confidence: 99%

Pore development in viscoelastic foods during drying

van der Sman,

Curatolo,

Teresi

2024

Soft Matter

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“…Various fascinating structures were prepared by adding polyvinylpyrrolidone (PVP), and the shell thickness decreased with an increase in the temperature. 57 Gajjar et al explored lactose for inhalation with the nondestructive 3D X-μCT methodology. 7,58 It distinguished the difference between the sieving and milling types by the particle size distribution based on the X-μCT technique.…”

Section: Study Of Pellets and Microsphere Preparationmentioning

confidence: 99%

“…The information from X-μCT showed that the size, porosity, and surface roughness of the mannitol particles increased with higher d -mannitol aqueous concentration, whereas the sphericity decreased. Various fascinating structures were prepared by adding polyvinylpyrrolidone (PVP), and the shell thickness decreased with an increase in the temperature …”

Section: Discovery Of 3d Structures In Ddssmentioning

confidence: 99%

Advances in Structure Pharmaceutics from Discovery to Evaluation and Design

Xue

et al. 2023

Mol. Pharmaceutics

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Drug delivery systems (DDSs) play an important role in delivering active pharmaceutical ingredients (APIs) to targeted sites with a predesigned release pattern. The chemical and biological properties of APIs and excipients have been extensively studied for their contribution to DDS quality and effectiveness; however, the structural characteristics of DDSs have not been adequately explored. Structure pharmaceutics involves the study of the structure of DDSs, especially the three-dimensional (3D) structures, and its interaction with the physiological and pathological structure of organisms, possibly influencing their release kinetics and targeting abilities. A systematic overview of the structures of a variety of dosage forms, such as tablets, granules, pellets, microspheres, powders, and nanoparticles, is presented. Moreover, the influence of structures on the release and targeting capability of DDSs has also been discussed, especially the in vitro and in vivo release correlation and the structure-based organ- and tumor-targeting capabilities of particles with different structures. Additionally, an in-depth discussion is provided regarding the application of structural strategies in the DDSs design and evaluation. Furthermore, some of the most frequently used characterization techniques in structure pharmaceutics are briefly described along with their potential future applications.

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“…To accurately characterize such particles, using a simple geometric model, one requires three characteristic lengths, i.e., length, width, and thickness. X-ray Computed Tomography (XCT) [62][63][64][65][66][67][68], offline stereoscopic imaging [69,70], digital holography [71] and fluorescence confocal microscopy combined with image processing [72] are some of the techniques that are capable of accurate 3D reconstruction of single or several particles. Despite their ability to fully reconstruct the 3D shape, these techniques have associated disadvantages in terms of the minimum resolution or the time taken to characterize an ensemble of particles.…”

Section: Introductionmentioning

confidence: 99%

Combined Imaging and Chromatic Confocal Microscopy Technique to Characterize Size and Shape of Ensembles of Cuboidal Particles

Neoptolemou

Vetter

Cruz‐Cabeza

et al. 2023

Preprint

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The presence of needle- and plate-like particles has detrimental consequences on their downstream processing in the fine chemicals sector. Therefore, the ability to accurately characterize the particle size and shape of the powder is essential to quantify and predict their impact on the product processability. Nonetheless, tools able to characterize the size and -- most importantly -- the shape, of ensembles of cuboidal crystals are seldom available. Thus, the overarching goal of this work is to provide a fast and accurate offline size and shape characterization tool. To this aim, we have designed and experimentally validated a combined imaging and chromatic confocal microscopy technique. We propose two modes of operation: one that facilitates the 3D reconstruction of particles at the expense of characterization time; and the other that facilitates rapid characterization without the need to 3D reconstruct the particles. We evaluate and validate the performance of our technique, using a commercial technique as a reference, by characterizing particles that exhibit differences in size and shape characteristics and optical properties. We show that our technique can be used to accurately obtain three characteristic lengths (length, width, and thickness) for thousands of particles, making it a valuable addition to existing process analytical technology.

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Single droplets to particles - size, shape, shell thickness and porosity analyses using X-ray computed tomography

Cited by 9 publications

References 74 publications

Pore development in viscoelastic foods during drying

Pore development in viscoelastic foods during drying

Advances in Structure Pharmaceutics from Discovery to Evaluation and Design

Combined Imaging and Chromatic Confocal Microscopy Technique to Characterize Size and Shape of Ensembles of Cuboidal Particles

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