Low-dimensional electronic systems have traditionally been obtained by electrostatically confining electrons, either in heterostructures or in intrinsically nanoscale materials such as single molecules, nanowires, and graphene. Recently, a new paradigm has emerged with the advent of symmetry-protected surface states on the boundary of topological insulators, enabling the creation of electronic systems with novel properties. For example, time reversal symmetry (TRS) endows the massless charge carriers on the surface of a three-dimensional topological insulator with helicity, locking the orientation of their spin relative to their momentum 1,2 . Weakly breaking this symmetry generates a gap on the surface, 3 resulting in charge carriers with finite effective mass and exotic spin textures 4 . Analogous manipulations of the one-dimensional boundary states of a two-dimensional topological insulator are also possible, but have yet to be observed in the leading candidate materials 5,6 . Here, we demonstrate experimentally that charge neutral monolayer graphene displays a new type of quantum spin Hall (QSH) effect 7,8 , previously thought to exist only in time reversal invariant topological insulators 5,9-11 , when it is subjected to a very large magnetic field angled with respect to the graphene plane. Unlike in the TRS case 5,9,10 , the QSH presented here is protected by a spin-rotation symmetry that emerges as electron spins in a half-filled Landau level are polarized by the large in-plane magnetic field. The properties of the resulting helical edge states can be modulated by balancing the applied field against an intrinsic antiferromagnetic instability [12][13][14] , which tends to spontaneously break the spin-rotation symmetry. In the resulting canted antiferromagnetic (CAF) state, we observe transport signatures of gapped edge states, which constitute a new kind of one-dimensional electronic system with tunable band gap and associated spin-texture 15 .In the integer quantum Hall effect, the topology of the bulk Landau level (LL) energy bands 16 requires the existence of gapless edge states at any interface with the vacuum. The metrological precision of the Hall quantization can be traced to the inability of these edge states to backscatter due to the physical separation of modes with opposite momentum by the insulating sample bulk 17 . In contrast, counterpropagating boundary states in a symmetry-protected topological (SPT) insulator coexist spatially but are prevented from backscattering by a symmetry of the experimental system 1,2 . The local symmetry that protects transport in SPT surface states is unlikely to be as robust as the inherently nonlocal physical separation that protects the quantum Hall effect. However, it enables the creation of new electronic systems in which momentum and some quantum number such as spin are coupled, potentially leading to devices with new functionality. Most experimentally realized SPT phases are based on TRS, with counterpropagating states protected from intermixing by the Kram...