2014
DOI: 10.2147/ndt.s73975
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Single event-related changes in cerebral oxygenated hemoglobin using word game in schizophrenia

Abstract: Neuroimaging studies have been conducted using word generation tasks and have shown greater hypofrontality in patients with schizophrenia compared with healthy subjects. In this study, we compared the characteristics of oxygenated hemoglobin changes involved in both phonological and categorical verbal fluency between 35 outpatients with schizophrenia and 35 healthy subjects during a Japanese “shiritori” task using single-event-related near-infrared spectroscopy. During this task, the schizophrenic patients sho… Show more

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Cited by 7 publications
(13 citation statements)
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“…With reference to our previous research, the pre‐task baseline was set to 1 s before presenting the stimulus, and the post‐task baseline was set to a period of 11 s from 10 s after the stimulus presentation. Linear fitting was applied to the data between these two baselines.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…With reference to our previous research, the pre‐task baseline was set to 1 s before presenting the stimulus, and the post‐task baseline was set to a period of 11 s from 10 s after the stimulus presentation. Linear fitting was applied to the data between these two baselines.…”
Section: Methodsmentioning
confidence: 99%
“…It is thought that the impairment causes social dysfunction, and that this is closely associated with the function of the PFC . Moreover, based on several cognitive tasks that activate the frontal lobe, schizophrenia is reportedly related to dysfunction of the PFC, encompassing the sites of executive function and WM . Takizawa et al .…”
mentioning
confidence: 99%
“…NIRS is considered the best means of detecting cortical activity during the naturally performed WGL or verbal fluency test due to its low sensitivity to motion artifact by overt speech [5,9,26]. Although NIRS is a non-invasive functional brain imaging method, it is a powerful tool because near-infrared light do not only penetrate into tissues, but it is also differentially absorbed by hemoglobin (Hb) depending on its oxygenation state and the optical path length in tissues (modified Beer-Lambert Law).…”
Section: Introductionmentioning
confidence: 99%
“…Recently, in schizophrenia Fujiki et al [9] reported significantly reduced activation of bilateral prefrontal cortex compared to healthy subjects during the Shiritori task using multichannel NIRS, which was firstly applied to the Shiritori task in the English literature published internationally (this is described in the paper and also investigated by us). Although this study indicated usability of NIRS during Shiritori task performance with overt speech in detecting differences of activation in schizophrenia compared to healthy subjects, cortical activation patterns of healthy subjects themselves were not clarified.…”
Section: Introductionmentioning
confidence: 99%
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