Single-injection COVID-19 subunit vaccine elicits potent immune responses

Zhou, Xiaoyong; Wang, H.; Luo, Ying; Cui, Lei; Guan, Ying; Zhang, Yongjun

doi:10.1016/j.actbio.2022.08.006

Cited by 6 publications

(5 citation statements)

References 37 publications

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“…[58] Zhou et al synthesized a single-injection multiple pulsed-release COVID-19 vaccine (Figure 3d). [59] First, a coprecipitation method was used to encapsulate the protein in CaCO 3 microspheres. [60] Then, in order to encapsulate the [49] Copyright 2020, American Chemical Society.…”

Section: Polyphenol-based Vaccine Delivery Nanosystemsmentioning

confidence: 99%

“…[ 58 ] Zhou et al synthesized a single‐injection multiple pulsed‐release COVID‐19 vaccine (Figure 3d). [ 59 ] First, a coprecipitation method was used to encapsulate the protein in CaCO 3 microspheres. [ 60 ] Then, in order to encapsulate the CaCO 3 microspheres with TA/PEG films, an underlying poly(ethylene imine) layer was first deposited, followed by layers of TA and PEG layer by layer.…”

Section: Applicationsmentioning

confidence: 99%

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Polyphenol‐Based Assembly Nanosystems as Multifunctional Biopharmaceutical Platform

Jiang

Zhang

et al. 2023

Advanced NanoBiomed Research

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Polyphenolic compounds are a diverse collection of secondary metabolites. They are present in nature and have potential therapeutic and medical value due to their anti‐inflammatory, antibacterial, and antitumor activities, as well as antioxidant capacity. Moreover, polyphenolic compounds can bind to biological macromolecules (e.g., peptides, proteins, nucleic acids, etc.) through various interactions, including hydrogen bonds, hydrophobic interactions, electrostatic interactions, π interactions, metal–ligand bonds, and covalent bonds, in the presence of catechol and gallol moieties. This endows polyphenols with strong adhesion and provides diverse approaches for designing and constructing biopharmaceutical platforms using multifunctional polyphenol components. Herein, a review of the synthesis and characteristics of polyphenol‐based bioactive assembly nanosystems by concentrating on the multi‐interactions between polyphenols and biomacromolecules is demonstrated. The polyphenol‐based bioactive assembly nanosystems exhibit remarkable versatility in a wide range of biological applications, including protein/antigen delivery, hemostasis, antimicrobial, gene therapy, and cell therapy. This may shed light on future developments in the field of bio‐based medicine.

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Section: Polyphenol-based Vaccine Delivery Nanosystemsmentioning

confidence: 99%

Section: Applicationsmentioning

confidence: 99%

Polyphenol‐Based Assembly Nanosystems as Multifunctional Biopharmaceutical Platform

Jiang

Zhang

et al. 2023

Advanced NanoBiomed Research

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“… Sketch representing the release profile including several pulses of vaccine against SARS-CoV-2 using LbL particles. Reprinted from Zhou et al [ 102 ]. Copyright (2022), with permission from Elsevier.…”

Section: Figurementioning

confidence: 99%

“… Sketch representing the fabrication process and action mechanism of self-boosting core-shell microparticle vaccines. Reprinted from Di et al [ 102 , 103 ]. Copyright (2023), with permission from John Wiley and Sons.…”

Section: Figurementioning

confidence: 99%

“…The results of the immunization using this type of vaccines were very promising, leading to potent and persistent S1-specific The research of LbL vaccine particles with a time-controlled pulsatile release has also been developed in the context of the SARS-CoV-2/COVID-19 pandemic outbreak. Zhou et al [102] proposed the fabrication of a single injection COVID-19 vaccine based on LbL particles. For this purpose, they proposed the assembly of LbL particles by conjugating the antigen, S1 subunit of SARS-CoV-2 spike protein, in CaCO3 microspheres, followed by coating with a multilayer obtained by the alternate deposition of tannic acid (TA) and polyethylene glycol (PEG).…”

Section: Lbl Capsules For Vaccinationmentioning

confidence: 99%

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Layer-by-Layer Nanoassemblies for Vaccination Purposes

2023

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In recent years, the availability of effective vaccines has become a public health challenge due to the proliferation of different pandemic outbreaks which are a risk for the world population health. Therefore, the manufacturing of new formulations providing a robust immune response against specific diseases is of paramount importance. This can be partially faced by introducing vaccination systems based on nanostructured materials, and in particular, nanoassemblies obtained by the Layer-by-Layer (LbL) method. This has emerged, in recent years, as a very promising alternative for the design and optimization of effective vaccination platforms. In particular, the versatility and modularity of the LbL method provide very powerful tools for fabricating functional materials, opening new avenues on the design of different biomedical tools, including very specific vaccination platforms. Moreover, the possibility to control the shape, size, and chemical composition of the supramolecular nanoassemblies obtained by the LbL method offers new opportunities for manufacturing materials which can be administered following specific routes and present very specific targeting. Thus, it will be possible to increase the patient convenience and the efficacy of the vaccination programs. This review presents a general overview on the state of the art of the fabrication of vaccination platforms based on LbL materials, trying to highlight some important advantages offered by these systems.

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Single‐Administration Self‐Boosting Microneedle Patch for the Treatment of Obesity

Singh,

Vinikoor,

Sharma

et al. 2024

Advanced Therapeutics

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Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) are one of the most effective treatments for obesity. The current therapy associated with repeated subcutaneous injections to maintain the drug therapeutic effect causes patient compliance issues and raises environmental concerns (due to sharp biohazard waste from disposed syringes/needles). Herein, a programmable scheduled release microneedles (PSR‐MNs) system is reported for delivering Semaglutide (a GLP‐1 RA agent with a half‐life of ≈7 days) to manage and treat obesity. A single skin administration of a PSR‐MNs patch (2 cm × 2 cm) that contains 4 programmable core‐shell microneedle (MNs) patches (1 cm2 each, so‐called pixels) enables the repeated release of Semaglutide every 7 days and sustains the drug efficacy for an unprecedented one‐month period, simulating the effect of using four bolus injections spaced 7 days apart. This PSR‐MNs system provides an advanced injection‐free platform to significantly enhance the current treatment of obesity with GLP‐1RAs, addressing concerns related to pain, needle phobia, high cost, and the need of medical facilities/personnel in traditional injections to administer the drug.

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Single-injection COVID-19 subunit vaccine elicits potent immune responses

Cited by 6 publications

References 37 publications

Polyphenol‐Based Assembly Nanosystems as Multifunctional Biopharmaceutical Platform

Polyphenol‐Based Assembly Nanosystems as Multifunctional Biopharmaceutical Platform

Layer-by-Layer Nanoassemblies for Vaccination Purposes

Single‐Administration Self‐Boosting Microneedle Patch for the Treatment of Obesity

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