Single intracutaneous injection of local anesthetics and steroids alleviates acute nonspecific neck pain

Yang, Xiaona; Geng, Zhu-sheng; Zhang, Xiuli; Zhang, Yunhai; Wang, Xinling; Zhang, Xiaobao; Cui, Jizheng

doi:10.1097/md.0000000000011285

Cited by 10 publications

(27 citation statements)

References 18 publications

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“…Seven articles (N=7) satisfied the inclusion criteria and were considered in the review: 2 articles treated osteoarthritis of the knee,16,17 and 5 articles treated spine diseases 2 on neck pain,18,19 2 on low back pain,20,21 and 1 on chronic spinal pain 22. The PEDro scores in these studies ranged from 5 to 8 (Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…With respect to the assessment of pain and function of the spine, the authors used specific scales and, specifically, the Neck Disability Index (NDI), a valid and sensitive tool for measuring changes in pain and disability in patients with musculoskeletal neck pain,18,19,27 and the Patient-Specific Functional Scale (PSFS), a patient-specific outcome measure that examines the functional status of the spine 21,28. The Knee Injury and Osteoarthritis Outcome Score (KOOS) is used to quantify short-term and long-term symptoms and function in subjects with knee injury and osteoarthritis 17,29…”

Section: Resultsmentioning

confidence: 99%

“…Finally, to evaluate the increase in quality of life that is perceived by patients, the Short Form-12 Health Survey (SF-12), a 12-item questionnaire that assesses generic health outcomes from the patient’s perspective, was administered 18,30. The self-reported Patient Global Impression of Change (PGIC) scale quantifies how the patients’ health change in painful condition 19,31…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, with drug mixtures, it is not possible to identify the effects of individual drugs with regard to efficacy and tolerability. Saggini et al17 examined the combination of NSAIDs and anesthetics, and Yang et al19 combined a steroid and anesthetic. The use of a single drug appears to reduce the risk of drug-drug interactions and local side effects 1…”

Section: Discussionmentioning

confidence: 99%

“…Yang et al19 demonstrated that intracutaneous injection (MLB) of local anesthetics and steroid into the affected paravertebral area is sufficient to relieve acute nonspecific neck pain and that the analgesic effect is more potent than that of oral ibuprofen (IBP). VAS scores at various time points (3 h, 1 day, and 3 days) declined from 7 to 4 in the IBP group and 6 to 3 in the MLB group.…”

Section: Discussionmentioning

confidence: 99%

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<p>Mesotherapy in the treatment of musculoskeletal pain in rehabilitation: the state of the art</p>

Paolucci¹,

Rg²,

Centra³

et al. 2019

JPR

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Background Mesotherapy can be included as an ancillary treatment in the management of localized pain in rehabilitation, but there are no definitive treatment protocols for this approach. Objectives The purpose of this review was to examine new indications for more standard protocols of mesotherapy in rehabilitation. Materials and methods This systematic review was performed using the following resources: PubMed, Cochrane, PEDro, Scopus, and Google Scholar. The following algorithm was developed, based on the PICO acronym, to evaluate the effects of mesotherapy, with pain as the primary outcome (MESH terms): [mesotherapy AND pain], [mesotherapy AND musculoskeletal], [mesotherapy AND musculoskeletal disorder], [intradermal therapy AND pain], and [intradermal therapy AND musculoskeletal disorder]. Results Seven articles (N=7) satisfied the inclusion criteria and were considered in the review: two of them treated osteoarthritis of the knee (3 sessions) and pes anserine (9 sessions) emphasizing a good efficacy of mesotherapy. Five studies analyzed spine diseases (specifically, two was about chronic and nonspecific neck pain, two about acute low back pain and one about chronic spinal pain): the results of mesotherapy treatment are encouraging both for the resolution of acute and chronic musculoskeletal vertebral pain from one to five sessions. Conclusion Mesotherapy showed a good effect to reduce acute and chronic musculoskeletal pain and, also, it is a well-tolerated treatment. Nonetheless future randomized controlled trials should be desirable for more uniform treatment protocols.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

<p>Mesotherapy in the treatment of musculoskeletal pain in rehabilitation: the state of the art</p>

Paolucci¹,

Rg²,

Centra³

et al. 2019

JPR

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Phosphonoamidates & Phosphopnoamidines: A convenient Synthesis, Spectroscopic Properties, DFT Calculations & Pharmacological Studies

Omrani

Ali

Arfaoui

et al. 2021

Journal of Molecular Structure

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Mesotherapy: From Historical Notes to Scientific Evidence and Future Prospects

Mammucari

Maggiori

Russo³

et al. 2020

The Scientific World Journal

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Intradermal therapy, known as mesotherapy, is a technique used to inject a drug into the surface layer of the skin. In particular, it involves the use of a short needle to deposit the drug in the dermis. The intradermal microdeposit modulates the drug’s kinetics, slowing absorption and prolonging the local mechanism of action. It is successfully applied in the treatment of some forms of localized pain syndromes and other local clinical conditions. It could be suggested when a systemic drug-sparing effect is useful, when other therapies have failed (or cannot be used), and when it can synergize with other pharmacological or nonpharmacological therapies. Despite the lack of randomized clinical trials in some fields of application, a general consensus is also reached in nonpharmacological mechanism of action, the technique execution modalities, the scientific rationale to apply it in some indications, and the usefulness of the informed consent. The Italian Mesotherapy Society proposes this position paper to apply intradermal therapy based on scientific evidence and no longer on personal bias.

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Single intracutaneous injection of local anesthetics and steroids alleviates acute nonspecific neck pain

Abstract: Supplemental Digital Content is available in the text

Cited by 10 publications

References 18 publications

<p>Mesotherapy in the treatment of musculoskeletal pain in rehabilitation: the state of the art</p>

<p>Mesotherapy in the treatment of musculoskeletal pain in rehabilitation: the state of the art</p>

Phosphonoamidates & Phosphopnoamidines: A convenient Synthesis, Spectroscopic Properties, DFT Calculations & Pharmacological Studies

Mesotherapy: From Historical Notes to Scientific Evidence and Future Prospects

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