Single-Layer MoS<sub>2</sub>-Based Nanoprobes for Homogeneous Detection of Biomolecules

Zhu, Chunyin; Zeng, Zhiyuan; Li, Hai; Fan, Li; Chen, Fan; Zhang, Hua

doi:10.1021/ja4019572

Cited by 1,027 publications

(834 citation statements)

References 69 publications

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“…H igh-quality and single-layered molybdenum disulfide (MoS 2 ) has been synthesized by chemical vapour deposition (CVD) over the past 2 years [1][2][3][4][5][6][7][8][9] , boosting its promise in applications involving hydrogen evolution reaction 10 , supercapacitors 11 , ultra-low power consumption field-effect transistors and phototransistor 12,13 , spintronic devices 14 , nonlinear optics 15 and biosensors 16 . CVD-grown MoS 2 atomic layers are also superior to samples prepared by mechanical exfoliation and chemical isolation methods, as continuous monolayer MoS 2 (hereafter 1H-MoS 2 ) can currently be grown at the centimetre-length scale 3,11,17,18 .…”

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confidence: 99%

Strain and structure heterogeneity in MoS2 atomic layers grown by chemical vapour deposition

et al. 2014

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Monolayer molybdenum disulfide (MoS 2 ) has attracted tremendous attention due to its promising applications in high-performance field-effect transistors, phototransistors, spintronic devices and nonlinear optics. The enhanced photoluminescence effect in monolayer MoS 2 was discovered and, as a strong tool, was employed for strain and defect analysis in MoS 2 . Recently, large-size monolayer MoS 2 has been produced by chemical vapour deposition, but has not yet been fully explored. Here we systematically characterize chemical vapour deposition-grown MoS 2 by photoluminescence spectroscopy and mapping and demonstrate non-uniform strain in single-crystalline monolayer MoS 2 and strain-induced bandgap engineering. We also evaluate the effective strain transferred from polymer substrates to MoS 2 by three-dimensional finite element analysis. Furthermore, our work demonstrates that photoluminescence mapping can be used as a non-contact approach for quick identification of grain boundaries in MoS 2 .

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mentioning

confidence: 99%

Strain and structure heterogeneity in MoS2 atomic layers grown by chemical vapour deposition

et al. 2014

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“…Recent studies indicate that the MoS 2 surfaces have high polarity and hydrophilicity [20], which lead DNA to adsorb through van der Waals forces between the four nitrogenous nucleobases and the basal plane of MoS 2 [18]. For example, in the report of Maddocks et al [21], guanine, one of the four DNA bases, was observed, by using scanning tunneling microscopy (STM), to form a stable two-dimensional ordered array.…”

Section: Resultsmentioning

confidence: 99%

“…MoS 2 nanosheets, nanofibers, and nanorods have been prepared [15], which means the material could readily be used to construct electronic devices with nanoscale dimensions. Several recent studies have examined the interaction of DNA with MoS 2 [15,18]. However, the adsorption of DNA origami structures on MoS 2 surfaces has not previously been explored.…”

Section: Introductionmentioning

confidence: 99%

DNA origami deposition on native and passivated molybdenum disulfide substrates

Zhang¹,

Rahman²,

Neff³

et al. 2014

Beilstein J. Nanotechnol.

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Maintaining the structural fidelity of DNA origami structures on substrates is a prerequisite for the successful fabrication of hybrid DNA origami/semiconductor-based biomedical sensor devices. Molybdenum disulfide (MoS 2 ) is an ideal substrate for such future sensors due to its exceptional electrical, mechanical and structural properties. In this work, we performed the first investigations into the interaction of DNA origami with the MoS 2 surface. In contrast to the structure-preserving interaction of DNA origami with mica, another atomically flat surface, it was observed that DNA origami structures rapidly lose their structural integrity upon interaction with MoS 2 . In a further series of studies, pyrene and 1-pyrenemethylamine, were evaluated as surface modifications which might mitigate this effect. While both species were found to form adsorption layers on MoS 2 via physisorption, 1-pyrenemethylamine serves as a better protective agent and preserves the structures for significantly longer times. These findings will be beneficial for the fabrication of future DNA origami/MoS 2 hybrid electronic structures. 501

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“…Monolayer MoS 2 nanosheets have been used as a biosensor for DNA detection based on their strong fluorescence‐quenching effect 122. In another example, based on 2D g‐C 3 N 4 nanosheet, a DNA biosensor was designed by utilizing the affinity changes of g‐C 3 N 4 to DNA probes upon their targeting the analyte and the related positron emission tomography (PET)‐based fluorescence‐quenching effect 123.…”

Section: Biosensingmentioning

confidence: 99%

Insights into 2D MXenes for Versatile Biomedical Applications: Current Advances and Challenges Ahead

2018

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Great and interdisciplinary research efforts have been devoted to the biomedical applications of 2D materials because of their unique planar structure and prominent physiochemical properties. Generally, ceramic‐based biomaterials, fabricated by high‐temperature solid‐phase reactions, are preferred as bone scaffolds in hard tissue engineering because of their controllable biocompatibility and satisfactory mechanical property, but their potential biomedical applications in disease theranostics are paid much less attention, mainly due to their lack of related material functionalities for possibly entering and circulating within the vascular system. The emerging 2D MXenes, a family of ultrathin atomic nanosheet materials derived from MAX phase ceramics, are currently booming as novel inorganic nanosystems for biologic and biomedical applications. The metallic conductivity, hydrophilic nature, and other unique physiochemical performances make it possible for the 2D MXenes to meet the strict requirements of biomedicine. This work introduces the very recent progress and novel paradigms of 2D MXenes for state‐of‐the‐art biomedical applications, focusing on the design/synthesis strategies, therapeutic modalities, diagnostic imaging, biosensing, antimicrobial, and biosafety issues. It is highly expected that the elaborately engineered ultrathin MXenes nanosheets will become one of the most attractive biocompatible inorganic nanoplatforms for multiple and extensive biomedical applications to profit the clinical translation of nanomedicine.

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Single-Layer MoS₂-Based Nanoprobes for Homogeneous Detection of Biomolecules

Abstract: A single-layer MoS2 nanosheet exhibits high fluorescence quenching ability and different affinity toward ssDNA versus dsDNA. As a proof of concept, the MoS2 nanosheet has been successfully used as a sensing platform for the detection of DNA and small molecules.

Cited by 1,027 publications

References 69 publications

Strain and structure heterogeneity in MoS2 atomic layers grown by chemical vapour deposition

Strain and structure heterogeneity in MoS2 atomic layers grown by chemical vapour deposition

DNA origami deposition on native and passivated molybdenum disulfide substrates

Insights into 2D MXenes for Versatile Biomedical Applications: Current Advances and Challenges Ahead

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Single-Layer MoS2-Based Nanoprobes for Homogeneous Detection of Biomolecules

Abstract: A single-layer MoS2 nanosheet exhibits high fluorescence quenching ability and different affinity toward ssDNA versus dsDNA. As a proof of concept, the MoS2 nanosheet has been successfully used as a sensing platform for the detection of DNA and small molecules.

Cited by 1,027 publications

References 69 publications

Strain and structure heterogeneity in MoS2 atomic layers grown by chemical vapour deposition

Strain and structure heterogeneity in MoS2 atomic layers grown by chemical vapour deposition

DNA origami deposition on native and passivated molybdenum disulfide substrates

Insights into 2D MXenes for Versatile Biomedical Applications: Current Advances and Challenges Ahead

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Product

Resources

About

Single-Layer MoS₂-Based Nanoprobes for Homogeneous Detection of Biomolecules