Single Loading Dose of Magnesium Sulphate in Severe Preeclampsia and Eclampsia-Is it Effective? A Randomized Prospective Study

Dasgupta, S; Sarkhel, Ashima; Jain, Anita

doi:10.15406/ogij.2015.02.00059

Cited by 9 publications

(21 citation statements)

References 17 publications

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“…Women on the 24‐hour MgSO 4 maintenance dose had a shorter hospital stay compared with their counterparts on the 12‐hour maintenance arm, although this was not significant. In contrast, the comparative, prospective, randomized study by Dasgupta et al . in India on the effectiveness of a single loading dose of MgSO 4 in severe pre‐eclampsia and eclampsia reported a shorter duration of mothers’ hospital stay among the participants with severe pre‐eclampsia on the single loading arm (compared with the standard Pritchard regimen).…”

Section: Discussionmentioning

confidence: 99%

Intravenous magnesium sulfate in the management of severe pre‐eclampsia: A randomized study of 12‐hour versus 24‐hour maintenance dose

Unwaha

Bello

et al. 2020

Intl J Gynecology & Obste

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Objective To assess the effectiveness of a 12‐hour versus 24‐hour intravenous maintenance dose of magnesium sulfate (MgSO4) in women with pre‐eclampsia, and the maternal and fetal outcomes. Methods This was a randomized controlled trial conducted at the labor ward complex of University College Hospital, Ibadan, Nigeria between May and August 2014. Pregnant women with severe pre‐eclampsia were randomized to receive a 12‐hour versus 24‐hour maintenance dose of MgSO4. Study outcomes were occurrence of seizures, adverse maternal effects, neonatal survival, and admission to the intensive care unit. Data analysis involved descriptive statistics and bivariate analysis using Statistical Package for Social Science (SPSS) version 20. Results There were 80 patients randomized to the 12‐hour (n=40) and 24‐hour (n=40) groups. The participants in the two groups had comparable demographic features. There was no significant difference (P>0.999) between the satisfactory maternal outcome following the 12‐hour maintenance dose and the standard 24‐hour regimen (95.0% vs 97.5%). Similarly, there was no significant difference (P=0.276) in perinatal mortality in the 12‐hour versus 24‐hour arm (17.5% vs 12.5%, respectively). No case of eclampsia and maternal death was recorded. Conclusion A 12‐hour maintenance dose of intravenous MgSO4 in the management of severe pre‐eclampsia is effective and safe when compared with the 24‐hour maintenance dose.

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Section: Discussionmentioning

confidence: 99%

Intravenous magnesium sulfate in the management of severe pre‐eclampsia: A randomized study of 12‐hour versus 24‐hour maintenance dose

Unwaha

Bello

et al. 2020

Intl J Gynecology & Obste

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show abstract

“…Hence in India, standard Pritchard's regimen has been subjected to various modifications like Dhaka regimen, VIMS regimen, Suman and Sardesi regimen etc due to concerns over cost of treatme safety and limited patient to doctor ratio requiring regular and frequent monitoring of the patients who receive MgSO4. 8,[15][16][17] But the main question was what should be the ideal dose. Therefore in present study serum magnesium levels of eclamptic pregnant women receiving Pritchard regimen was compared with those treated with low dose regimen.…”

Section: Discussionmentioning

confidence: 99%

“…Antepartum eclampsia is commonest as shown by many studies which is comparable with the study which was seen in 70%. 8,[15][16][17] The normal serum magnesium levels vary from 1.6 to 2.1mEq/l. An IV dose of 4g Magnesium sulphate causes an immediate elevation of Magnesium level from normal to 7 to 9 mEq/L, subsequently due to intracellular transfer and renal elimination the concentration drops to 4 to 5 mEq/L by one hour.…”

Section: Discussionmentioning

confidence: 99%

Correlation of serum magnesium levels in eclampsia with pritchard and single dose magnesium sulphate regimen

Shreya

Nayana

2019

Int J Reprod Contracept Obstet Gynecol

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Background: Magnesium sulphate is anticonvulsant of choice for eclampsia. Single dose magnesium sulphate therapy was tried for the management of Eclampsia and Imminent Eclampsia considering the low body mass index of Indian population.Methods: A prospective interventional study comprising of total 80 patients having either eclampsia or imminent eclampsia, to whom the Pritchard or a single dose MgSO4 was given alternatively in a tertiary hospital from October 2014 to October 2017. Serum magnesium levels, maternal and perinatal outcome and recurrence of convulsions were evaluated using Student- t test and chi square test.Results: Mean Serum Magnesium levels in eclampsia and imminent eclampsia group at 0 min, 30 min, 4 hours in Pritchard regimen were 1.96mg/dl, 5.85mg/dl, 4.68mg/dl while in single dose regimen it was 1.78mg/dl, 462mg/dl, 3.63mg/dl respectively. Those who received Pritchard regimen showed higher level of Serum magnesium levels at 30 minutes and 4 hours than those receiving single dose. By applying T-test it was found that there is a significant difference in serum magnesium levels range in both group but no statistical difference in the control of convulsions in both groups.Conclusions: With increased and almost widespread use of magnesium sulfate in obstetrics there has been concerns regarding its safety. In the study, although P-values are not significant because of small sample size, there is considerable difference in serum magnesium levels 30 min and 4 hours, recurrence of convulsions and maternal morbidity between Pritchard regimen and single dose regimen. The goal which was achieved with Pritchard regimen previously, now can be achieved with single dose regimen in Indian women. Single dose magnesium sulphate is safe and effective in controlling convulsions with improved maternal and perinatal outcome.

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“…This is in accordance with Dasgupta who showed that magnesium toxicity was less with low dose therapy than with standard regimen. 18 There is ample evidence that the dose regime needs to be modified according to patient's weight. Phuapradit W et al from Bangkok -state that "it seems appropriate to take in to account body weight when considering the dosage of drug and the regime used is appropriate for Asian women with body weight usually less than 70kg".…”

Section: Discussionmentioning

confidence: 99%

A comparative study of low dose magnesium sulphate therapy with standard pritchard's regime in the management of eclampsia

Mohanapu

Raveendran

Murugaiah

et al. 2016

Int J Reprod Contracept Obstet Gynecol

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Single Loading Dose of Magnesium Sulphate in Severe Preeclampsia and Eclampsia-Is it Effective? A Randomized Prospective Study

Cited by 9 publications

References 17 publications

Intravenous magnesium sulfate in the management of severe pre‐eclampsia: A randomized study of 12‐hour versus 24‐hour maintenance dose

Intravenous magnesium sulfate in the management of severe pre‐eclampsia: A randomized study of 12‐hour versus 24‐hour maintenance dose

Correlation of serum magnesium levels in eclampsia with pritchard and single dose magnesium sulphate regimen

A comparative study of low dose magnesium sulphate therapy with standard pritchard's regime in the management of eclampsia

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