Single Magnetic Particle Motion in Magnetomotive Ultrasound: An Analytical Model and Experimental Validation

Levy, Benjamin E.; Oldenburg, Amy L.

doi:10.1109/tuffc.2021.3072867

Cited by 12 publications

(8 citation statements)

References 28 publications

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“…While the experimental work was limited to two concentrations of PVA, producing two different Young's moduli, FEA was used to demonstrate trends across a range of parameter values. The inverse dependency of magnetomotive displacement on Young's modulus, also reported by Levy and Oldenburg, 48 again implies a possibility to infer mechanical properties. [28][29][30] In addition to Young's modulus, changing the bubble radius was also found to affect the deformation, with larger displacements indicated for smaller radii, Figure 7.…”

Section: Discussionsupporting

confidence: 60%

Modelling of magnetic microbubbles to evaluate contrast enhanced magnetomotive ultrasound in lymph nodes – a pre-clinical study

Sjöstrand

Bacou

Kaczmarek

et al. 2022

BJR

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Objectives: Despite advances in MRI the detection and characterisation of lymph nodes in rectal cancer remains complex, especially when assessing the response to neo-adjuvant treatment. An alternative approach is functional imaging, previously shown to aid characterization of cancer tissues. We report proof of concept of the novel technique Contrast-Enhanced Magneto-Motive Ultrasound (CE-MMUS) to recover information relating to local perfusion and lymphatic drainage, and interrogate tissue mechanical properties through magnetically induced deformations. Methods: The feasibility of the proposed application was explored using a combination of experimental animal and phantom ultrasound imaging, along with finite element analysis. First, contrast enhanced ultrasound imaging on one wild type mouse recorded lymphatic drainage of magnetic microbubbles after bolus injection. Second, tissue phantoms were imaged using MMUS to illustrate the force- and elasticity dependence of the magneto-motion. Third, the magneto-mechanical interactions of a magnetic microbubble with an elastic solid were simulated using finite element software. Results: Accumulation of magnetic microbubbles in the inguinal lymph node was verified using contrast enhanced ultrasound, with peak enhancement occurring 3.7 s post injection. The magnetic microbubble gave rise to displacements depending on force, elasticity, and bubble radius, indicating an inverse relation between displacement and the latter two. Conclusions: Combining magnetic microbubbles with MMUS could harness the advantages of both techniques, to provide perfusion information, robust lymph node delineation and characterisation based on mechanical properties. Advances in knowledge: (a)Lymphatic drainage of magnetic microbubbles visualised using contrast enhanced ultrasound imaging and (b) magneto-mechanical interactions between such bubbles and surrounding tissue could both contribute to (c) robust detection and characterisation of lymph nodes.

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Section: Discussionsupporting

confidence: 60%

Modelling of magnetic microbubbles to evaluate contrast enhanced magnetomotive ultrasound in lymph nodes – a pre-clinical study

Sjöstrand

Bacou

Kaczmarek

et al. 2022

BJR

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“…A gas bubble contrast agent requires a thin encapsulating layer to increase its durability, stability, and acoustic properties . Magnetic nanomaterials, such as iron oxide, are rarely used for ultrasound imaging due to their resolution constraints, low echogenicity, and limited depth . However, there has been an increase in interest in using magnetic nanoparticles for ultrasound imaging.…”

Section: Contrast Agents Using Iron Oxidementioning

confidence: 99%

Crafting Iron Oxides for Next-Generation Biomedical Applications

Amrillah,

Notodidjojo,

Kalimanjaro

et al. 2024

Crystal Growth & Design

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Iron oxides are multifunctional materials that have been extensively explored for many applications, including in novel biomedical applications. However, boosting their ability for biomedical purposes remains a significant challenge. Many strategies have been proposed to increase the feasibility of iron oxides for biomedical applications, such as doping and defect engineering, compositing and decorating, surface and interface engineering, and structure and morphology development. This review focuses on the essential advancements of iron oxides for their implementation in biomedical applications. The discussion starts with the design of iron oxides in biomedical applications, such as drug delivery, heat delivery, contrast agents, biomedical nanorobots, and disease-sensing systems. We also discuss the obstacle of iron oxides in biomedical applications and continue by proposing a plausible strategy to enhance the feasibility of iron oxides in biomedical applications. The provided discussion and perspectives can enrich the information and pave the way to finding strategies to enhance the feasibility of iron oxides in biomedicalrelated applications. We believe that our review also could shed light on how to bring iron oxides close to real implementation for biomedical purposes.

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“…However, the particle can be pushed using any proper excitation technique, such as a magnetic force. Recently, Levy and Oldenburg [44] used magnetic force to excite a sphere inside the medium for elasticity imaging purposes. They formulated the motion of a magnetic particle exposed to the special magnetomotive ultrasound driving force in the frequency domain and then obtained an analytical expression by using the inverse Fourier transform as follows:…”

Section: Sphere Located Within the Tissuementioning

confidence: 99%

Elasticity and Viscoelasticity Imaging Based on Small Particles Exposed to External Forces

Koruk,

Pouliopoulos

2023

Processes

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Particle-mediated elasticity/viscoelasticity imaging has the potential to expand the elasticity imaging field, as it can provide accurate and local tissue elastic properties as well as density and viscosity. Here, we investigated elasticity imaging based on small particles located within the tissue and at the tissue interface exposed to static/dynamic external loads. First, we discuss elasticity/viscoelasticity imaging methods based on the use of particles (bubbles and rigid spheres) placed within the tissue. Elasticity/viscoelasticity imaging techniques based on the use of particles (bubbles, rigid, and soft spheres) located at the tissue interface are then presented. Based on new advances, we updated some of the models for the responses of the particles placed within the tissue and at the tissue interface available in the literature. Finally, we compared the mathematical models for the particles located within the tissue and at the tissue interface and evaluated the elasticity/viscoelasticity imaging methods based on the use of small particles. This review summarized the methods for measuring the elasticity and viscosity of material using particles exposed to external forces. Remote viscoelasticity imaging can be used to improve material characterization in both medical and industrial applications and will have a direct impact on our understanding of tissue properties or material defects.

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Single Magnetic Particle Motion in Magnetomotive Ultrasound: An Analytical Model and Experimental Validation

Cited by 12 publications

References 28 publications

Modelling of magnetic microbubbles to evaluate contrast enhanced magnetomotive ultrasound in lymph nodes – a pre-clinical study

Modelling of magnetic microbubbles to evaluate contrast enhanced magnetomotive ultrasound in lymph nodes – a pre-clinical study

Crafting Iron Oxides for Next-Generation Biomedical Applications

Elasticity and Viscoelasticity Imaging Based on Small Particles Exposed to External Forces

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