Single-Micelle-Templated Synthesis of Hollow Barium Carbonate Nanoparticle for Drug Delivery

Abstract

A laboratory-synthesized triblock copolymer poly(ethylene oxide-b-acrylic acid-b-styrene) (PEG-PAA-PS) was used as a template to synthesize hollow BaCO3 nanoparticles (BC-NPs). The triblock copolymer was synthesized using reversible addition–fragmentation chain transfer radical polymerization. The triblock copolymer has a molecular weight of 1.88 × 104 g/mol. Transmission electron microscopy measurements confirm the formation of spherical micelles with a PEG corona, PAA shell, and PS core in an aqueous solution. Furthermore, the dynamic light scattering experiment revealed the electrostatic interaction of Ba2+ ions with an anionic poly(acrylic acid) block of the micelles. The controlled precipitation of BaCO3 around spherical polymeric micelles followed by calcination allows for the synthesis of hollow BC-NPs with cavity diameters of 15 nm and a shell thickness of 5 nm. The encapsulation and release of methotrexate from hollow BC-NPs at pH 7.4 was studied. The cell viability experiments indicate the possibility of BC-NPs maintaining biocompatibility for a prolonged time.

Fabrication and Characterization of Zn Particle Incorporated Fibrous Scaffolds for Potential Application in Tissue Healing and Regeneration

“…PZ-10 and PCZ-10 show a drastic increase in the Young's modulus and UTS as the Zn particles tend to reinforce the polymeric matrix. However, as the Zn concentration increases beyond a threshold, abrupt changes in the polymeric matrix occur, presenting discontinuities and lowering UTS as seen in several other composite fibers of PCL with metallic nanoparticles, including Mg, Ca, Zn, Fe, and so forth. − …”

“…Briefly, the cell-laden fibrous scaffolds were treated with 10% AB reagent in cultured media and incubated for 4 h. Assay solutions were transferred to 96-well plates to measure fluorescence (530 nm excitation and 590 nm emission). The cell toxicity of PZ and PCZ scaffolds was evaluated using a Pierce LDH assay kit following the manufacturer’s instruction and also with reference to our previous work. , Briefly, 50 μL of collected sample media ( n = 3) was transferred to a 96-well plate and mixed with a 50 μL reaction mixture. The plate was covered with aluminum foil and incubated at room temperature for 30 min.…”

An Emerging Trend in the Synthesis of Iron Titanate Photocatalyst Toward Water Splitting

“…The surfactants assist in controlling morphology and generating pores. [56] Diana et al used top-down approach to synthesize FeTiO 3 NPs by milling the ilmenite concentrate and photocatalytic activity was enhanced by modification with Mg and MgO [2] . Electromagnetic and dry magnetic separation was used to obtain pure grains which were milled together with the composite precursor, Mg or MgO.…”

Ultrasmall Inorganic Mesoporous Nanoparticles: Preparation, Functionalization, and Application

“…In addition, the obtained ultrasmall mesoporous BaCO 3 nanoparticles had very high biocompatibility, which was promising for future intracellular biological applications (Figure 12f–h). [ 154 ] In recent years, ultrasmall Janus mesoporous nanoparticles have been particularly novel in biomedical applications due to the asymmetric mesoporous structure having better hemocompatibility than symmetric porous architectures. For example, asymmetric mesoporous silica nanoparticles with eccentric cavities and large pores of 25 nm could provide spatially separated storage spaces and transport channels for other large molecules.…”