Single Nodular Pulmonary Amyloidosis: Case Report

Abstract

Amyloidosis is defined as the presence of extra-cellular deposits of an insoluble fibrillar protein, amyloid. The pulmonary involvement of amyloidosis is usually classified as tracheobronchial, parenchymal nodular, or diffuse alveolar septal. A single nodular lesion can mimic various conditions, including malignancy, pulmonary tuberculosis, and fungal infection. To date, only one case of nodular pulmonary amyloidosis has been reported in Korea, a case involving multiple nodular lesions. Here, we report and discuss the case of a patient having single nodular amyloidosis.

Imaging features of pulmonary involvement in a case of systemic amyloidosis: A classic case

“…The patient also had bilateral pleural effusions, which is the most common finding in pleural involvement of amyloidosis [1]. Although pulmonary amyloidosis usually involves basal and peripheral lungs, upper lung involvement of nodular parenchymal amyloidosis has been reported [7]. In addition, minimal pericardial effusion as well as concentric and symmetrical left ventricular wall and interventricular septal thickening was also observed in this case, a common yet nonspecific finding in cardiac amyloidosis [1,8].…”

Case report: Pulmonary amyloidosis in two patients with chronic obstructive lung disease (COPD)

“…These proteins can vary in size and may form part of a systemic or local disease process [3,4]. The cornerstone of diagnosis remains obtaining biopsy material stained positive by Congo red dye using a polarized microscope which demonstrated a typical green bifiringence pattern [5,6].…”

Nodular Pulmonary Amyloidosis Mimicking Metastatic Pulmonary Nodules: A case report and review of the literature

“…It mainly occurs in patients with chronic infections and those with rheumatic or autoimmune diseases. 1,2 In contrast, primary lightchain amyloidosis is due to deposited kappa and lambda light chains and can be associated with multiple myeloma, Waldenström's macroglobulinaemia and asymptomatic monoclonal gammopathy. 1 Isolated pulmonary amyloidosis is rare and can be categorised into tracheobronchial, parenchymal nodular and diffuse alveolar septal amyloidosis.…”

“…idiopathic) or, more commonly, secondary to a variety of pathological conditions, including neoplastic, infectious and inflammatory aetiologies. [2][3][4] Pulmonary amyloidosis may be part of a systemic process or confined only to the lung, at which point it is classified as tracheobronchial, parenchymal nodular or diffuse alveolar septal pulmonary amyloidosis. 5,6 Although rare, nodular pulmonary amyloidosis can mimic other, more common, pulmonary disorders that manifest as multiple pulmonary masses or nodules, such as neoplastic and granulomatous conditions.…”

“…5,6 Although rare, nodular pulmonary amyloidosis can mimic other, more common, pulmonary disorders that manifest as multiple pulmonary masses or nodules, such as neoplastic and granulomatous conditions. 2,7,8 Therefore, pulmonary amyloidosis should be included in the differential diagnosis of single or multiple pulmonary nodules.…”