Single Nucleotide Polymorphism of the Interferon-γ Gene (IFN-γ +874 T/A) and the Prognosis of Hepatitis B Infection

Naghizadeh, Mohammad Sadegh; Naseri, Mohsen; Fereyduni, Mohammad; Ziaee, Masoud; Tane, Abdolghader; Safari, Hamidreza; Mahavar, Neda; Mahdavi, Roya; Sarab, Gholamreza Anani

doi:10.29252/jommid.6.2.3.43

Cited by 1 publication

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“…The effect arises from the binding of those SNPs to the Nuclear factor-kappa B (NF-κB) transcription factor, which is highly characteristic of the infection's course and progression (Pravica et al, 2000;Yu et al, 2006). Although several studies have been performed on the correlation between IFN-γ gene polymorphisms and HBV infection (Arababadi et al, 2011;Ghasemian and Shahbazi, 2016;Naghizadeh et al, 2018;Peng et al, 2007;Saxena et al, 2014;Sun et al, 2015a;Wei et al, 2016), non was performed to study such correlation among the Egyptian population. Thus the current study was tailored to investigate the role of IFN-γ +874T/A and +2109 A/G gene polymorphism in the susceptibility risk of Egyptians to HBV infection.…”

Section: Introductionmentioning

confidence: 99%

Association between interferon-gamma (IFN-γ) gene polymorphisms (+874A/T and +2109A/G), and susceptibility to hepatitis B viral infection (HBV)

Dondeti¹,

Abdelkhalek²,

Elezawy³

et al. 2022

J Appl Biomed

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Background: Interferon-gamma (IFN-γ) is a chief proinflammatory cytokine with a significant role in the immune response against viral infections. Today there is increasing evidence about the association between individual genetic polymorphisms and cytokines in predicting HBV infection susceptibility. Aim: This study aimed to investigate the association between IFN-γ gene polymorphisms and susceptibility to hepatitis B viral infection (HBV), and the impact of these genetic polymorphisms on IFN-γ production. IFN-γ (+874A/T, rs2430561, and +2109A/G, rs1861494) was genotyped by single-stranded polymorphism-polymerase chain reaction (SSP-PCR) in 126 Egyptians with chronic HBV infection and in 100 healthy control subjects. The plasma levels of IFN-γ were measured by Enzyme-linked immunosorbent assay (ELISA). Results: Compared to the control subjects there was a slight increase in +874TT genotype frequency in HBV patients. However, no statistical significance in IFN-γ (+874A/T and +2109A/G) genotype/allele distribution was demonstrated, indicating the lack of association between these SNPs and susceptibility to HBV infection. In +2109A/G, only AG genotype was observed with a complete abrogation of GG and AA genotypes. Haplotypes between different loci on selected genes showed insignificant changes in their frequency in patients and control subjects. HBV patients had a significantly higher level of IFN-γ (P < 0.001) compared to controls. The maximum significant increase in IFN-γ production was observed in subjects harboring the +874TA genotype. Conclusions: As no association could be characterized between the polymorphism in IFN-γ (+874A/T and +2109A/G) and susceptibility to chronic HBV infection, our data support the concept that IFN-γ gene polymorphisms are not predictors of HBV susceptibility in this segment of the Egyptian population.

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