Single nucleotide polymorphism (SNP) in the 5'-noncoding region of the bovine growth hormone receptor gene and its association with dairy production traits in Polish Black-and-White cattle

Maj, Andrzej; Strzałkowska, N.; Sloniewski, K.; Krzyżewski, J.; Oprządek, J.; Zwierzchowski, L.

doi:10.17221/4327-cjas

Cited by 9 publications

(4 citation statements)

References 17 publications

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“…PIT-1). Statistically significant associations between polymorphisms in these genes and milk production traits have been found (Kamiński et al, 2002;Liefers et al, 2002;Zwierzchowski et al, 2002;Maj et al, 2004;Kulig, 2005). Other genes of interest in this area include genes encoding enzymes which participate in fatty acid metabolism as well as genes encoding fatty acid binding and transport proteins (Hradecká et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

ANXA9, SLC27A3, FABP3 and FABP4 single nucleotide polymorphisms in relation to milk production traitsin Jersey cows

Kulig¹,

Kowalewska-Łuczak²,

Kmiec³

et al. 2010

CZECH J ANIM SCI

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Milk components originating from blood plasma substrates are synthesized in epithelial cells of the mammary gland. Milk lipids are synthesized from fatty acids which bind to specific proteins – FABPs (fatty acid binding proteins). FABPs are a family of small cytoplasmic proteins; nine members of the family have been identified so far (FABP1–FABP9) (Chmurzyńska et al., 2006). Their main roles include fatty acid uptake, transport and metabolism. FABPs can modulate the fatty acid concentration in cells and therefore they affect different cellular processes, especially lipid metabolism. FABP3 and FABP4 are present in tissues with a high demand for fatty acids, such as heart muscle, skeletal muscles, lactating mammary gland, liver or adipose tissue (Roy et al., 2003). FABP3 gene was mapped to bovine chromosome 2 (Calvo et al., 2004), where QTLs affecting milk fat yield and content were described (Khatkar et al., 2004). FABP4 gene was mapped to BTA14 (Michal et al., 2006), which is very rich in QTLs for milk production traits (Khatkar et al., 2004). Fatty acid transport is assisted by the specific proteins called FATPs (fatty acid transport proteins). This protein group includes SLC27A3 (solute carrier family 27, member 3). It belongs to the family of proteins that facilitate long-chain fatty acid transport across the cytoplasmic membrane. Another protein with similar functions is ANXA9 (annexin A9), the member of Ca2+ and phospholipid-binding protein family (Calvo et al., 2006b). Genes encoding SLC27A3 and ANXA9 were mapped to chromosome 3, within the region where QTLs for milk fat content and the other milk traits have been mapped. Both of the above-mentioned genes are expressed in the mammary gland (Calvo et al., 2006b). The polymorphic sites (SNPs – single nucleotide polymorphisms) within the bovine FABP3, FABP4, SLC27A3 and ANXA9 genes were identified (Wu et al., 2005; Calvo et al., 2006b; Michal et al., 2006; Cho et al., 2008). Associations between SNPs in these genes and milk production traits in cattle have not been reported so far. However, polymorphism in the FABP4 gene has been significantly associated with carcass traits in cattle (Michal et al., 2006; Cho et al., 2008). Due to their expression sites, physiological properties and chromosomal localisation, the described genes might be considered as candidate genes for milk production traits. The aim of this study was to determine allele and genotype frequencies and to establish possible associations between the ANXA9, SLC27A3, FABP3 and FABP4 SNPs, and selected milk traits in Jersey cows.

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Section: Discussionmentioning

confidence: 99%

ANXA9, SLC27A3, FABP3 and FABP4 single nucleotide polymorphisms in relation to milk production traitsin Jersey cows

Kulig¹,

Kowalewska-Łuczak²,

Kmiec³

et al. 2010

CZECH J ANIM SCI

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“…Other authors used blood groups and protein polymorphisms to evaluate genetic variation, even though the latter are presently studied more often to explain their relationship to performance (Maj et al, 2004;Kučerová et al, 2006, e.g.). Studying these polymorphisms, the aim is to identify the QTL affecting the important traits (Freyer and Vukasinovic, 2005).…”

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confidence: 99%

Study of genetic distances between cattle breeds of Central Europe

Čítek¹,

Panicke²,

Řehout³

et al. 2006

CZECH J ANIM SCI

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Genetic distances were studied among Czech Red cattle, German Red, Czech Pied, Polish Red, Czech Black and White, and German Black and White cattle. DA genetic distances were calculated, and trees were constructed using the Neighbour-Joining method. Evaluating the genetic distances by microsatellites, the lowest value was between Czech and German Black and White breeds. A surprisingly high value was found between Czech and German Red breeds, and the highest values between German Red breed and both German and Czech Black and White populations came up to expectations. In the phylogenetic tree made using microsatellites, the German and Polish Red breeds clustered, but Czech Red breed was not joined with them. The other cluster was obtained for Czech Black and White and German Black and White. The tree made of protein markers differed slightly. Because the populations of Czech and German Red breeds are small and also because of organizational issues, the common protection of Central-European red populations and breeding them as a gene pool are recommended.

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“…Some literature reports suggest that, in cattle, GHRAluI polymorphism is related to milk yield and milk composition (15). Similarly, several studies carried out in different cattle breeds have demonstrated that the GHR-F279Y polymorphism detected in the exon region of the GHR gene is also related with milk yield and milk composition (16).…”

Section: Discussionmentioning

confidence: 98%

Investigation of the promoter polymorphisms of the growth hormone (GH1), growth hormone receptor (GHR), insulin-like growth factor (IGF-I), and prolactin (PRL) genes and the correlation between gene expression and milk yields in Holstein cattle raised in Central Anatolia

Arslan¹,

Taheri²,

Şener³

et al. 2016

Turk J Vet Anim Sci

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Single nucleotide polymorphism (SNP) in the 5'-noncoding region of the bovine growth hormone receptor gene and its association with dairy production traits in Polish Black-and-White cattle

Cited by 9 publications

References 17 publications

ANXA9, SLC27A3, FABP3 and FABP4 single nucleotide polymorphisms in relation to milk production traitsin Jersey cows

ANXA9, SLC27A3, FABP3 and FABP4 single nucleotide polymorphisms in relation to milk production traitsin Jersey cows

Study of genetic distances between cattle breeds of Central Europe

Investigation of the promoter polymorphisms of the growth hormone (GH1), growth hormone receptor (GHR), insulin-like growth factor (IGF-I), and prolactin (PRL) genes and the correlation between gene expression and milk yields in Holstein cattle raised in Central Anatolia

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