Single nucleotide polymorphism (SNP) in growth hormone gene of Jakhrana, a prominent milk goat breed in India

Gupta, Neelam; Pandey, Alok; Malik, Geetu; Gupta, S.C.

doi:10.1016/j.smallrumres.2008.11.001

Cited by 21 publications

(14 citation statements)

References 17 publications

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“…The polymorphisms observed in this and other studies (Marques et al 2003;Gupta et al 2009;Mousavizadeh et al 2009) suggest that the gene can be used as a candidate gene in selection programs. Some of these mutations have been associated with high milk yield in Portuguese Algavia (Malveiro et al 2001), Indian Jakhrana (Gupta et al 2009) and Iranian Tali goats (Mousavizadeh et al 2009). The GH1 gene was more diverse within the SAB goats, as suggested by the highest gene diversity of 0.930 AE 0.005 (Table 1) Ten haplotypes were shared among the populations ( Table 2).…”

supporting

confidence: 62%

“…The GH1 gene has been observed to be highly polymorphic, especially in exons 1-5 in Serrana goat populations (Marques et al 2003). The polymorphisms observed in this and other studies (Marques et al 2003;Gupta et al 2009;Mousavizadeh et al 2009) suggest that the gene can be used as a candidate gene in selection programs. Some of these mutations have been associated with high milk yield in Portuguese Algavia (Malveiro et al 2001), Indian Jakhrana (Gupta et al 2009) and Iranian Tali goats (Mousavizadeh et al 2009).…”

supporting

confidence: 54%

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Targeted high‐throughput growth hormone 1 gene sequencing reveals high within‐breed genetic diversity in South African goats

et al. 2016

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This study assessed the genetic diversity in the growth hormone 1 gene (GH1) within and between South African goat breeds. Polymerase chain reaction-targeted gene amplification together with Illumina MiSeq next-generation sequencing (NGS) was used to generate the full length (2.54 kb) of the growth hormone 1 gene and screen for SNPs in the South African Boer (SAB) (n = 17), Tankwa (n = 15) and South African village (n = 35) goat populations. A range of 27-58 SNPs per population were observed. Mutations resulting in amino acid changes were observed at exons 2 and 5. Higher within-breed diversity of 97.37% was observed within the population category consisting of SA village ecotypes and the Tankwa goats. Highest pairwise FST values ranging from 0.148 to 0.356 were observed between the SAB and both the South African village and Tankwa feral goat populations. Phylogenetic analysis indicated nine genetic clusters, which reflected close relationships between the South African populations and the other international breeds with the exception of the Italian Sarda breeds. Results imply greater potential for within-population selection programs, particularly with SA village goats.

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confidence: 62%

supporting

confidence: 54%

Targeted high‐throughput growth hormone 1 gene sequencing reveals high within‐breed genetic diversity in South African goats

et al. 2016

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“…In gaddi goat, the three SNPs resulted in an average density of 1 SNP for every 90 bp sequence. The SNP at g.1939G > C have been previously reported in Black Bengal (11) and Jakhrana goats (7).…”

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confidence: 59%

Comparative Sequence Analysis in the Exon 5 of Growth Hormone Gene in the Various Livestock Species of India

Singh

Sharma

Kumari

et al. 2013

Animal Biotechnology

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The aim of the study was to identify genetic polymorphism in growth hormone (GH) gene locus of six different livestock species using PCR-Direct DNA sequencing method. In exon 5 of GH gene, 10 SNPs variants were identified in all livestock species studied, namely Bubalus bubalis, Bos indicus, Bos frontalis, Bos grunniens, Ovis aries, and Capra hircus. Four SNPs were observed in Bubalus bubalis, two SNPs in Bos indicus, one SNP in Ovis aries, and three SNPs in Capra hircus. No changes were observed in Bos grunniens and Bos frontalis when compared with the template sequence and the SNPs observed in the present investigation may be useful in the marker assisted selection.

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“…The amplified PCR products were further subjected to PAGE and visualized by silver staining (15). The different SSCP patterns were named AA, BB, and CC, as per international practice (16)(17)(18). The genetic variants were determined by singlestrand conformation polymorphism (SSCP) analysis.…”

Section: Pcr-sscp and Sequencing Analysismentioning

confidence: 99%

Single nucleotide polymorphism identification and characterization ofGnRHR gene in Bos taurus and Bos indicus cattle

Kerekoppa¹,

Basavaraju²,

Rao³

et al. 2015

Turk J Vet Anim Sci

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The hypothalamic gonadotropin-releasing hormone receptor (GnRHR) plays an essential physiological role in reproductive function. In this investigation, we studied genetic variation in the entire coding region of GnRHR gene using PCR-SSCP technique in 250 Bos taurus (Holstein Friesian, Jersey) and Bos indicus (Malnad Gidda, Deoni) bulls. The genetic variants in GnRHR gene were determined by PCR-SSCP technique by using 5 sets of primers. SSCP analysis of fragment 1, comprising exon 1, and fragment 3, comprising exon 2, revealed 2 SSCP patterns in all breeds under study, while fragment 2 of exon 1 and fragment 4, comprising exon 3, revealed 3 patterns in Malnad Gidda; Holstein Friesian and Deoni breeds showed 2 SSCP patterns. In Jersey bulls, fragment 4 showed 3 patterns. The fragment 5 comprising exon 3 was monomorphic in all 4 breeds under study. SNPs were confirmed by direct sequencing.

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Single nucleotide polymorphism (SNP) in growth hormone gene of Jakhrana, a prominent milk goat breed in India

Cited by 21 publications

References 17 publications

Targeted high‐throughput growth hormone 1 gene sequencing reveals high within‐breed genetic diversity in South African goats

Targeted high‐throughput growth hormone 1 gene sequencing reveals high within‐breed genetic diversity in South African goats

Comparative Sequence Analysis in the Exon 5 of Growth Hormone Gene in the Various Livestock Species of India

Single nucleotide polymorphism identification and characterization ofGnRHR gene in Bos taurus and Bos indicus cattle

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