Single-Nucleotide Polymorphisms and Cancer Risk, Tumor Recurrence, or Survival of Head and Neck Cancer Patients

Laytragoon‐Lewin, Nongnit; Cederblad, Lena; Andersson, Bengt-Åke; Olin, Mattias; Nilsson, Mats; Rutqvist, Lars Erik; Lundgren, Jan; Engström, Mats; Tytor, Wieslaw; Löfgren, Sture; Lewin, Freddi

doi:10.1159/000452278

Cited by 9 publications

(3 citation statements)

References 32 publications

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“…Plasma cytokine and chemokine analysis. Based on previous investigations, plasma IL2, IL6, IL10, IL12, interferon-gamma (IFNγ) or tumour necrosis factor alpha (TNFα), CCL2, CCL4, CCL5 and platelet-derived growth factor (PDGF)-bb were selected as candidate blood-based biomarkers (1,12,21,22). Customised fluorochrome kits for multiplex fluorochrome technique (Luminex xMAPTM Technology, Austin, TX, USA) were purchased from Bio-Rad Laboratories (Bio-Rad Laboratories, Hercules, CA, USA).…”

Section: Methodsmentioning

confidence: 99%

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The Influence of Single Nucleotide Polymorphisms and Adjuvant Radiotherapy on Systemic Inflammatory Proteins, Chemokines and Cytokines of Patients With Breast Cancer

et al. 2019

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Independently of tumour and treatment modulation, the host immune response status plays an important role in the clinical outcome of patients with cancer. The influence of single nucleotide polymorphisms (SNPs) and adjuvant radiotherapy (RT) on the systemic immune response status of patients with breast cancer was investigated. Materials and Methods: Eighty-six female patients recovering from breast cancer surgery were investigated. As a control cohort, 82 healthy female blood donors were used. Blood-based SNPs, plasma C-reactive protein (CRP), cytokines and chemokines were analyzed for this purpose. Results: Independently of tumour stage and hormone receptor status, dysregulation of plasma CRP, chemokine (C-C motif) ligand 4 (CCL4) and interleukin 2 (IL2), but not CCL5, CCL2, platelet-derived growth factor, IL6, IL10, IL12, interferon-gamma or tumour necrosis factor alpha were detected in the patients when compared to controls. The extent of alteration in plasma levels of CRP and IL2 patients was significantly associated with SNPs in CRP rs1800947 and IL2 rs6822844, respectively. These SNPs had no influence on the levels of corresponding plasma biomarkers in the healthy controls. Adjuvant RT reduced plasma CRP and CCL5 levels in patients with regards to CRP rs1800947CC, CCL5 rs2107538GG and CCL5 rs2280789AA sequences. Conclusion: Dysregulation of immune responses, as indicated by plasma levels of CRP, CCL4 and IL2 were found in patients with breast cancer despite the removal of the tumour mass. The benefit of adjuvant RT, as indicated by reduced plasma amounts of inflammatory protein CRP and chemokine CCL5 were based on the SNPs of the patients. Analyses of blood-based SNPs, plasma CRP, IL2 and CCL5 are low cost, rapid and can be carried out using general laboratory facilities while requiring only a peripheral blood sample. The possibility of using these blood-based biomarkers as an indicator of patient immune status for selection of individual patient treatment warrants further investigation.Adjuvant radiotherapy (RT) is an essential treatment of breast cancer and various types of solid tumours after surgery. Independently of tumour and treatment modulation, the host immune response status plays an important role in the clinical outcome of patients with cancer (1). Recently, a combination of RT and immunotherapy was suggested (2-4).The anti-neoplastic properties of RT are primarily related to induction of DNA damage and cell death. Bystander effects can also develop in cells not directly hit by RT (5).These processes can in turn lead to the alteration of host immune responses driven by intra-and intercellular communication via inflammatory proteins, chemokines and cytokines (6-9).The intensity of host systemic inflammatory responses can be assessed by monitoring the level of plasma C-reactive protein (CRP) (10,11). Following the recovery stage, the plasma CRP level returns to a normal value. Increased plasma CRP levels were associated with a poor clinical outcome in patients with cancer independently of tumourn...

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Section: Methodsmentioning

confidence: 99%

“…The levels of inflammatory proteins, chemokines and cytokines are suggested to be associated with individual genetic variations (6,8,9). Major contributors to genetic variations are single nucleotide polymorphisms (SNPs) found within DNA sequences (9,21).…”

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The Influence of Single Nucleotide Polymorphisms and Adjuvant Radiotherapy on Systemic Inflammatory Proteins, Chemokines and Cytokines of Patients With Breast Cancer

et al. 2019

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“…The studies on gene polymorphism can lay an important foundation of molecular biology for revealing the mechanism of malignant tumors, and they have important roles in clarifying tumor susceptibility and predicting the development trend of tumors. Single nucleotide polymorphism (SNP), as the most common type of human genetic variation, is an important part of the research on gene polymorphism and can be used to explore the mechanism of tumor generation ( 12 , 13 ).…”

Section: Introductionmentioning

confidence: 99%

Correlation Between TNFAIP2 Gene Polymorphism and Prediction/Prognosis for Gastric Cancer and Its Effect on TNFAIP2 Protein Expression

Guo

et al. 2020

Front. Oncol.

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Objective: TNFAIP2 is a novel gene induced by TNF-α and participates in inflammatory reaction and tumor angiogenesis. This study aims to understand the correlation between TNFAIP2 gene polymorphism and prediction as well as prognosis of gastric cancer (GC) in a Chinese population. Methods: One thousand two hundred seventy-nine cases were enrolled, including 640 GC and 639 non-cancer cases. The functional tagSNPs of the TNFAIP2 gene were screened by Haploview software and NIH Snpinfo website. Human whole-blood genomic DNA was extracted by phenol chloroform method and analyzed by KASP SNP typing and sequencing method. ELISA was used to determine the expression of TNFAIP2 protein in serum samples. The miRNAs bound to TNFAIP2 3′ UTR rs8126 were predicted by MirSNP and TargetScan database. SPSS 22.0 software was used for statistical analysis, and P < 0.05 showed statistical difference. Results: Four functional TNFAIP2 tagSNPs were found by bioinformatics analysis. TNFAIP2 rs8126 T>C polymorphism increased GC risk, and the risk in TC genotype cases was higher than that in TT genotype cases ( P = 0.001, OR = 1.557). In the dominant model, the TNFAIP2 rs8126 polymorphic carrier was 1.419 times higher ( P = 0.007). TNFAIP2 rs710100 C>T polymorphism, TNFAIP2 rs3759571 G>A polymorphism, and TNFAIP2 rs3759573 A>G polymorphism were not correlated with GC risk. In the subgroup analysis, TNFAIP2 rs8126 TC genotype cases had a higher GC risk in male, aged 60 years or older, Helicobacter pylori -negative, non-smoking, and non-drinking. However, there was no correlation between TNFAIP2 SNPs and GC prognosis. The TNFAIP2 protein concentration in GC patients was significantly different from that in healthy persons ( P = 0.029), but it was not associated with GC prognosis. The high or low expression of TNFAIP2 protein had no significant difference with gender, age, H. pylori infection, smoking, and drinking in GC patients. The serum TNFAIP2 protein expression in rs8126 TT genotype carriers was significantly higher than that in rs8126 CC genotype carriers ( P < 0.001). Conclusion: TNFAIP2 3′ UTR rs8126 T>C polymorphism was associated with GC risk in a Chinese population, especially in cases with males aged 60 years or older, H. pylori negative, non-smoking and non-drinking. Compared with healthy persons, serum TNFAIP2 protein expression was higher in Chinese GC patients, and TNFAIP2 3′ UTR rs8126 T>C polymorphism might affect TNFAIP2 protein expression.

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Prevalence and significance of M541L single nucleotide polymorphism in the central European cohort of gastrointestinal stromal tumor patients

Jašek

Grendár

Stanclova

et al. 2020

J Cancer Res Clin Oncol

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Single-Nucleotide Polymorphisms and Cancer Risk, Tumor Recurrence, or Survival of Head and Neck Cancer Patients

Cited by 9 publications

References 32 publications

The Influence of Single Nucleotide Polymorphisms and Adjuvant Radiotherapy on Systemic Inflammatory Proteins, Chemokines and Cytokines of Patients With Breast Cancer

The Influence of Single Nucleotide Polymorphisms and Adjuvant Radiotherapy on Systemic Inflammatory Proteins, Chemokines and Cytokines of Patients With Breast Cancer

Correlation Between TNFAIP2 Gene Polymorphism and Prediction/Prognosis for Gastric Cancer and Its Effect on TNFAIP2 Protein Expression

Prevalence and significance of M541L single nucleotide polymorphism in the central European cohort of gastrointestinal stromal tumor patients

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