Single nucleotide polymorphisms cumulating to genetic variation for fertility in crossbred (
            <i>Bos taurus</i>
            ×
            <i>Bos indicus</i>
            ) bull spermatozoa

Sinha, Manish Kumar; Kumaresan, A.; King, John Peter Ebenezer Samuel; Prakash, M. Arul; Nag, Pranab Kumar; Paul, Nilendu; Raval, Kathan; Elango, K.; Aranganathan, V.

doi:10.1080/10495398.2022.2124166

Cited by 5 publications

(1 citation statement)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our previously published research (Ebenezer Samuel King et al, 2022) [22] , we identified a notable missense mutation in the DMXL1 gene. Consequently, we aimed to investigate whether the DMXL1 gene exhibited any variations in expression associated with semen quality differences between good and poor semen samples.…”

Section: Discussionmentioning

confidence: 69%

DMXL1 could be a potential candidate gene for semen quality in Holstein Friesian bulls

King,

Kumaresan,

Sinha

et al. 2023

Pharma Innovation

View full text Add to dashboard Cite

The herd's overall financial success is closely tied to the reproductive efficiency of the breeding bulls. Reduced reproductive efficiency in dairy cattle often arises due to the subfertility or infertility of the breeding bulls. In this study, our main focus is on identifying candidate genes containing SNPs within the QTL region, with the goal of using them as markers to predict semen quality. Our study reports the relationship between DMXL1 gene and sperm motility in cattle bulls. Diverse studies emphasized the significance of DMXL1 in various cellular processes and pathways, encompassing cell cycle regulation, cell proliferation, and signal transduction. Further investigation into the DMXL1 gene could offer valuable insights and potentially position it as a candidate gene for semen quality in breeding bulls.

show abstract

Section: Discussionmentioning

confidence: 69%

DMXL1 could be a potential candidate gene for semen quality in Holstein Friesian bulls

King,

Kumaresan,

Sinha

et al. 2023

Pharma Innovation

View full text Add to dashboard Cite

show abstract

Whole transcriptome sequencing of testis and epididymis reveals genes associated with sperm development in roosters

Guo,

Cong,

Zhu

et al. 2024

BMC Genomics

View full text Add to dashboard Cite

Background Chickens play a crucial role as the primary global source of eggs and poultry, and the quality of rooster semen significantly impacts poultry reproductive efficiency. Therefore, it is imperative to comprehend the regulatory mechanisms underlying sperm development. Results In this study, we established transcriptome profiles of lncRNAs, miRNAs, and mRNAs in 3 testis tissues and 3 epididymis tissues from “Jing Hong No.1” roosters at 24, 35, and 64 weeks of age. Using the data, we conducted whole transcriptome analysis and constructed a ceRNA network. We detected 10 differentially expressed mRNAs (DEmRNAs), 33 differentially expressed lncRNAs (DElncRNAs), and 10 differentially expressed miRNAs (DEmiRNAs) in the testis, as well as 149 DEmRNAs, 12 DElncRNAs, and 10 DEmiRNAs in the epididymis. These genes were found to be involved in cell differentiation and development, as well as various signaling pathways such as GnRH, MAPK, TGF-β, mTOR, VEGF, and calcium ion pathways. Subsequently, we constructed two competing endogenous RNA (ceRNA) networks comprising DEmRNAs, DElncRNAs, and DEmiRNAs. Furthermore, we identified four crucial lncRNA-mRNA-miRNA interactions that govern specific biological processes in the chicken reproductive system: MSTRG.2423.1-gga-miR-1563- PPP3CA and MSTRG.10064.2-gga-miR-32-5p- GPR12 regulating sperm motility in the testis; MSTRG.152556.1-gga-miR-9-3p- GREM1 / THYN1 governing immunomodulation in the epididymis; and MSTRG.124708.1-gga-miR-375- NDUFB9 / YBX1 controlling epididymal sperm maturation and motility. Conclusions Whole transcriptome sequencing of chicken testis and epididymis screened several key genes and ceRNA regulatory networks, which may be involved in the regulation of epididymal immunity, spermatogenesis and sperm viability through the pathways of MAPK, TGF-β, mTOR, and calcium ion. These findings contribute to our comprehensive understanding of the intricate molecular processes underlying rooster spermatogenesis, maturation and motility. Supplementary Information The online version contains supplementary material available at 10.1186/s12864-024-10836-8.

show abstract

Determinant genetic markers of semen quality in livestock

Khan,

Chen,

Naz

et al. 2024

Front. Endocrinol.

View full text Add to dashboard Cite

The reproductive efficiency of livestock is crucial for agricultural productivity and economic sustainability. One critical factor in successful fertilization and the viability of offspring is the quality of semen. Poor semen quality, especially in frozen-thawed semen used in artificial insemination (AI) have been shown to influence conception outcomes, resulting a negative impact on livestock production. Recent advancements in genetic research have identified specific markers linked to semen quality traits in various livestock species, such as cattle, sheep, goats, pigs, buffalo, and equines. These genetic markers are essential in screening males for breeding suitability, which in turn enhances selective breeding programs. Understanding these markers is crucial for improving reproductive performance and increasing productivity in livestock populations. This review offers a comprehensive overview of the genetic markers associated with semen quality in key livestock. It explores the underlying genetic mechanisms and their practical implications in animal breeding and management. The review underscores the importance of integrating genetic insights into breeding strategies to optimize reproductive efficiency and ensure the sustainable development of livestock industries.

show abstract

Single nucleotide polymorphisms cumulating to genetic variation for fertility in crossbred ( Bos taurus × Bos indicus ) bull spermatozoa

Cited by 5 publications

References 65 publications

DMXL1 could be a potential candidate gene for semen quality in Holstein Friesian bulls

DMXL1 could be a potential candidate gene for semen quality in Holstein Friesian bulls

Whole transcriptome sequencing of testis and epididymis reveals genes associated with sperm development in roosters

Determinant genetic markers of semen quality in livestock

Contact Info

Product

Resources

About