Single Nucleotide Polymorphisms in Growth Hormone Gene  and Their Association with Growth Traits in  Siniperca chuatsi (Basilewsky)

Tian, Changxu; Yang, Min; Lv, Liyuan; Yuan, Yongchao; Liang, Xu‐Fang; Guo, Wenjie; Song, Yi; Zhao, Cheng

doi:10.3390/ijms15047029

Cited by 36 publications

(18 citation statements)

References 25 publications

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“…Similar polymorphisms have been reported by Zhang, Shao, Jiang, Li and Xu (2009) in the Nibea coibor GH gene, but has not been reported in other fish species (Almuly et al, 2005;Ma et al, 2012;Qu er e et al, 2010;Ryyn€ anen & Primmer, 2004;Tian et al, 2014). This 6 bp repeat motif (GAACCA) is dominantly repeated four times, but some individuals have an additional insertion of the repeat.…”

Section: Haplotype Identification and Relationship Of Pmagh Haplotysupporting

confidence: 82%

Polymorphisms of the growth hormone gene in domesticated red sea bream populations (Pagrus major) based on minisatellite genotypes and nucleotide sequences

2018

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The genetic diversity of the growth hormone gene in domesticated red sea bream (pmaGH) was evaluated using a minisatellite DNA marker located in intron 3 (pmaGH22) and nucleotide sequences. The number of alleles of pmaGH22 was largely decreased in domesticated strains of red sea bream, and the possibility of selection pressures was also detected based on the analysis of the Hardy-Weinberg equilibrium in some strains. However, each strain inherited a small number of alleles of pmaGH22, and the entire domesticated population (combining all strains) showed a large number of alleles (n = 17), similar to the allelic richness of the wild population (n = 18.5). Based on nucleotide sequencing analysis, three synonym mutations were found in the coding regions, and also several SNPs and indels were found in the noncoding regions. In addition, four genealogies of growth hormone haplotypes were identified based on principal coordinate analysis, and these genealogies of pmaGH partly reflected allele size ranges of pmaGH22. Several haplotypes shared alleles of pmaGH22, and also fragment size homoplasy in pmaGH22 was suspected.These alleles of pmaGH22 and the haplotypes will be a useful indicator for divergence of pmaGH and for broodstock individual selection with minimum inbreeding effect. K E Y W O R D Sgrowth hormone, indel, minisatellite, Pagrus major, red sea bream, SNP

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Section: Haplotype Identification and Relationship Of Pmagh Haplotysupporting

confidence: 82%

Polymorphisms of the growth hormone gene in domesticated red sea bream populations (Pagrus major) based on minisatellite genotypes and nucleotide sequences

2018

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“…Moreover, we attempted to evaluate their potential to improve growth traits of O. potamophila through MAS. In addition, this study could strengthen our understanding of the growth regulation of O. potamophila and facilitate MAS for favorable alleles in aquaculture breeding programs (Tian et al ).…”

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confidence: 88%

Characterization and Identification of Single Nucleotide Polymorphism Within the IGF‐1R Gene Associated with Growth Traits of Odontobutis potamophila

Zhang

Zhao

Yin

et al. 2018

J World Aquaculture Soc

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IGF-1R plays a critical role in many physiological activities, such as development, growth, metabolism, and reproduction. Identification of genetic markers in the IGF-1R gene significantly associated with important growth traits of Odontobutis potamophila may accelerate genetic improvement. In this study, we characterized the cDNA sequence of the IGF-1R gene of O. potamophila, and our data revealed that IGF-1R contained an open reading frame of 1650 bp, encoding a polypeptide of 549 amino acids (aa). Quantitative real-time polymerase chain reaction demonstrated that IGF-1R was ubiquitously expressed in all tested tissues, and the most predominant expression of IGF-1R was detected in gonad. Moreover, IGF-1R was expressed at different developmental stages from embryo to larva, and its highest expression level was found at the morula stage. In addition, we identified three single nucleotide polymorphisms (SNPs; 1777T>C, 1704G>A, and 1208G>A) within IGF-1R locus and found that one SNP (1208G>A) was significantly associated with important growth traits of O. potamophila. Results showed that the overall length, body length, trunk width, caudal peduncle length, body weight, and body width in fish with AG genotype were significantly greater compared with those with GG genotype (P < 0.05). However, the other two SNPs (1777T>C and 1704G>A) did not show significant associations with any growth traits. Therefore, SNPs within the IGF-1R locus could be used as a selection criterion to improve growth traits of O. potamophila.

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“…; Tian et al . ). S tructural changes such as exonisations and pseudoexonisation in multiple genes are a possible consequence of mutations, including nucleotide substitutions, insertions and deletions (Xu et al .…”

Section: Introductionmentioning

confidence: 97%

New insight into the diversity of exon and intron 5 regions of Oncorhynchus mykiss growth hormone (GH) gene: sexual dimorphism in the GH gene

Akbarialmajough

Manaffar

Najdegerami

et al. 2018

Reviews in Aquaculture

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The growth in vertebrates is controlled by growth hormone (GH) gene which is a member of the somatotropin/prolactin family. In salmonids, a series of gene duplications is thought to have occurred in GH gene. In this family, the diversity in intron and exon regions of the GH gene is assumed to be not only in charge of a different growth rate but also in sex maturation. Due to the sex determination importance in salmonids, especially during early stages of development, in present study, an easy and accurate molecular marker was investigated for sex determination of Oncorhynchus mykiss fish using the diversity of the exon and intron 5 of GH gene. A pseudogene (GH‐ψ) copy of growth hormone gene was found on the Y chromosome which is in homology with type‐2 GH genes that can be used for sexual dimorphism of this species. This pseudogene was detected using a specific primer pairs combination using polymerase chain reaction (PCR) to select monosex female population. As recent findings suggest new functions of pseudogenes in the regulation of gene expression, it is believed that the putative gene could have an impact on GH expression in this species.

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Single Nucleotide Polymorphisms in Growth Hormone Gene and Their Association with Growth Traits in Siniperca chuatsi (Basilewsky)

Cited by 36 publications

References 25 publications

Polymorphisms of the growth hormone gene in domesticated red sea bream populations (Pagrus major) based on minisatellite genotypes and nucleotide sequences

Polymorphisms of the growth hormone gene in domesticated red sea bream populations (Pagrus major) based on minisatellite genotypes and nucleotide sequences

Characterization and Identification of Single Nucleotide Polymorphism Within the IGF‐1R Gene Associated with Growth Traits of Odontobutis potamophila

New insight into the diversity of exon and intron 5 regions of Oncorhynchus mykiss growth hormone (GH) gene: sexual dimorphism in the GH gene

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