Single nucleotide polymorphisms of IL-2 , but not IL-12 and IFN - γ , are associated with increased susceptibility to chronic spontaneous urticaria

Movahedi, Masoud; Tavakol, Marzieh; Rahmani, Farzaneh; Amirzargar, Ali Akbar; Bidoki, Alireza Zare; Heidari, Kazem; Gharagozlou, M; Aghamohammadi, Asghar; Nabavi, Mohammad; Soltani, Shahin; Rezaei, Nima

doi:10.1016/j.aller.2016.10.009

Cited by 6 publications

(3 citation statements)

References 26 publications

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“…NK2 cells are capable of producing many important cytokines, including IL-4, IL-5, and IL-13, which further aggravates the pathology of CSU ( 188 ). Consistent with this, decreased levels of IFN-γ in serum of patients with CSU suggest that NK1 cells are not dominant compared with NK2 cells ( 189 ).…”

Section: The Crosstalk Of Immune Cells In Csusupporting

confidence: 54%

The Role of Crosstalk of Immune Cells in Pathogenesis of Chronic Spontaneous Urticaria

Zhou

et al. 2022

Front. Immunol.

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Chronic spontaneous urticaria (CSU) is defined as recurrent episodes of spontaneous wheal development and/or angioedema for more than six weeks and at least twice a week. The core link in the pathogenesis of CSU is the activation of mast cells, T cells, eosinophils, and other immune cells infiltrating around the small venules of the lesion. Increased vascular permeability, vasodilatation, and recruitment of inflammatory cells directly depend on mast cell mediators’ release. Complex regulatory systems tightly influence the critical roles of mast cells in the local microenvironment. The bias toward Th2 inflammation and autoantibodies derived from B cells, histamine expressed by basophils, and initiation of the extrinsic coagulation pathway by eosinophils or monocytes exerts powerful modulatory influences on mast cells. Cell-to-cell interactions between mast cells and eosinophils/T cells also are regulators of their function and may involve CSU’s pathomechanism. This review summarizes up-to-date knowledge regarding the crosstalk between mast cells and other immune cells, providing the impetus to develop new research concepts and treatment strategies for CSU.

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Section: The Crosstalk Of Immune Cells In Csusupporting

confidence: 54%

The Role of Crosstalk of Immune Cells in Pathogenesis of Chronic Spontaneous Urticaria

Zhou

et al. 2022

Front. Immunol.

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“…No report of the association between IL-2 + 166 polymorphism and IBD currently exists in the literature. Meanwhile previous studies from Iran demonstrated that the IL-2 (-330, +160) GT haplotype is more common in people with irritable bowel syndrome [29], chronic spontaneous urticaria [61], juvenile systemic lupus erythematosus [55], and juvenile idiopathic arthritis [56]. The present study indicated that the IL-2 -330 GG genotype is associated with both CD and UC, whereas the GT genotype of this SNP is protective toward CD in Iranian patients.…”

Section: Discussionmentioning

confidence: 50%

Association of T Helper 1 Cytokine Gene Single Nucleotide Polymorphisms with Ulcerative Colitis and Crohn’s Disease

Daryani

Sadr²,

Soltani³

et al. 2018

Dig Dis

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Background: Inflammatory bowel disease (IBD) mostly comprised of Crohn’s disease (CD) and ulcerative colitis (UC) is a condition arising from the combined effects of genetic, environmental, and immunological factors. IBD is associated with inflammation and altered cytokine profile. Objective: This study was aimed at assessing the association between T helper type 1 (Th1) cytokine polymorphisms (interferon gamma [IFN-γ] +874 A/T, interleukin-12 [IL-12] –1188 A/C, IL-2 –330 G/T, IL-2 +166 G/T) and susceptibility to and clinical features of IBD. Methods: The study population was composed of 75 IBD patients (40 CD patients and 35 UC patients) and 140 healthy controls. Genotyping was performed using polymerase chain reaction with sequence-specific primers. Results: The A allele of IFN-γ +874 polymorphism was overrepresented in the whole population of patients with IBD (OR 1.63; 95% CI 1.08–2.47; p = 0.020) and as well in the subpopulation of patients with CD (OR 2.14; 95% CI 1.26–3.63; p = 0.004), but not in UC. Multiple pairwise comparisons indicated that genotypes of single nucleotide polymorphisms (SNPs) within the IL-2 and IFN-γ genes are correlated with IBD, CD, and UC, while neither allele nor genotype frequency of th1 IL-12 –1188 polymorphism was associated with IBD, CD, or UC. Haplotype analysis also revealed that the presence of IL-2 –330/+166 TG haplotype versus the remaining haplotypes (GG, TT, and GT) is a protective factor against IBD (OR 0.62; p = 0.046). Conclusions: The present study reports (for the first time) significant associations between SNPs within the IFN-γ and IL-2 genes and IBD.

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“…4 Polymorphism of IL2 -330T/G might also affect transcription and translation of the IL-2 gene through activation of the transcription factor. 5 Recently, it was estimated that IL-2 polymorphisms are related to susceptibility to several diseases, such as chronic spontaneous urticaria 6 and Graves' disease. 7 However, there are conflicting results regarding the impact of IL2 -330T/G polymorphism on the risk of pulmonary TB.…”

Section: Introductionmentioning

confidence: 99%

Lack of association between polymorphism of IL-2 -330T/G and pulmonary tuberculosis among Caucasians

Chen

Zhu

2020

Innate Immun

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This meta-analysis was conducted to assess the consistency and strength of the relationship between polymorphism of IL-2 -330T/G and susceptibility to pulmonary tuberculosis (TB). PubMed, Web of Knowledge and CNKI were searched to find eligible studies about the relationship between IL-2 -330T/G polymorphism and susceptibility to pulmonary TB. A total of eight studies comprising 971 cases and 1519 controls were grouped together for the purpose of elucidating the relationship between polymorphism of IL-2 -330T/G and pulmonary TB susceptibility. The allele model (G vs. T: odds ratio (OR) = 1.34; 95% confidence interval (CI) 1.05–1.71, Phet = 0.001) and the recessive model (GG+GT vs. TT: OR = 1.60; 95% CI 1.08–2.38, Phet = 0.0001) showed an increased risk of development of pulmonary TB. However, the homozygous model (GG vs. TT: OR = 1.74; 95% CI 0.98–3.09, Phet = 0.0005) and the dominant model (GG vs. TT + TG: OR = 1.30; 95% CI = 0.80-2.14, Phet = 0.001) failed to show an increased incidence of pulmonary TB. When analysis was stratified by ethnicity, no obvious associations were identified in the Caucasian subgroup under all four genetic models. Additionally, heterogeneity disappeared in the analysis of Caucasian subgroup. Our combined data suggested that there was no association between IL-2 -330T/G polymorphism and pulmonary TB among Caucasians.

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Single nucleotide polymorphisms of IL-2 , but not IL-12 and IFN - γ , are associated with increased susceptibility to chronic spontaneous urticaria

Abstract: SNP at position -330 and +166 of IL-2 gene are differently expressed in CSU. The haplotype GT of IL-2 at -330 and +166 might confer vulnerability to a number of immunological disorders in Iranian region.

Cited by 6 publications

References 26 publications

The Role of Crosstalk of Immune Cells in Pathogenesis of Chronic Spontaneous Urticaria

The Role of Crosstalk of Immune Cells in Pathogenesis of Chronic Spontaneous Urticaria

Association of T Helper 1 Cytokine Gene Single Nucleotide Polymorphisms with Ulcerative Colitis and Crohn’s Disease

Lack of association between polymorphism of IL-2 -330T/G and pulmonary tuberculosis among Caucasians

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