Single-nucleotide polymorphisms of matrix metalloproteinases and their inhibitors in gastrointestinal cancer

Langers, Alexandra M. J.; Verspaget, Hein W.; Hommes, Daniël W.; Sier, Cornelis F.M.

doi:10.4251/wjgo.v3.i6.79

Cited by 24 publications

(21 citation statements)

References 104 publications

(176 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Single-nucleotide polymorphisms (SNPs) of MMP-1 seems to increase cancer risk of digestive tract tumors (Langers et al, 2011) and recently a À1607 1G-to-2G MMP-1 polymorphism has been associated with susceptibility to both development and progression of lung cancer (Liu et al, 2011). In breast cancer expression levels of MMP-1 have been found altered, suggesting some role for this collagenase (Köhr-mann et al, 2009).…”

Section: Neoplastic Diseasesmentioning

confidence: 99%

Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes

Sbardella

Fasciglione

Gioia

et al. 2012

Molecular Aspects of Medicine

209

212

View full text Add to dashboard Cite

a b s t r a c tHuman matrix metalloproteinases (MMPs) belong to the M10 family of the MA clan of endopeptidases. They are ubiquitarian enzymes, structurally characterized by an active site where a Zn 2+ atom, coordinated by three histidines, plays the catalytic role, assisted by a glutamic acid as a general base. Various MMPs display different domain composition, which is very important for macromolecular substrates recognition. Substrate specificity is very different among MMPs, being often associated to their cellular compartmentalization and/or cellular type where they are expressed. An extensive review of the different MMPs structural and functional features is integrated with their pathological role in several types of diseases, spanning from cancer to cardiovascular diseases and to neurodegeneration. It emerges a very complex and crucial role played by these enzymes in many physiological and pathological processes.

show abstract

Section: Neoplastic Diseasesmentioning

confidence: 99%

Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes

Sbardella

Fasciglione

Gioia

et al. 2012

Molecular Aspects of Medicine

209

212

View full text Add to dashboard Cite

show abstract

“…Studies were performed to evaluate the association of MMP-2 -1306 C/T polymorphism with colon cancer risk [59] . Langer et al [53,60] reported that presence of CC or CT genotype enhances the survival rate of colon cancer patients. There is also a significant association of MMP-2 -735 C/T polymorphism with esophageal cancer risks [54] .…”

Section: Mmps Polymorphism In Tumor Formationmentioning

confidence: 99%

“…MMP-2 polymorphism was investigated mainly in the promoter region, e.g., MMP-2 -1306 C/T, -735 C/T, -790T/G, -955A/C, and -1575G/A in the context of gastrointestinal cancer risk [53] . Studies reported association of gastrointestinal cancer risk with -1306 C/T and -735 C/T polymorphic site worldwide.…”

Section: Mmps Polymorphism In Tumor Formationmentioning

confidence: 99%

Matrix metalloproteinases and gastrointestinal cancers: Impacts of dietary antioxidants

Verma

Kesh

Ganguly

et al. 2014

WJBC

View full text Add to dashboard Cite

teinase (TIMP) which bind MMPs with a 1:1 stoichiometry. In addition, RECK (reversion including cysteinerich protein with kazal motifs) is a membrane bound glycoprotein that inhibits MMP-2, -9 and -14. Moreover, α2-macroglobulin mediates the uptake of several MMPs thereby inhibit their activity. Cancerous conditions increase intrinsic reactive oxygen species (ROS) through mitochondrial dysfunction leading to altered protease/ anti-protease balance. ROS, an index of oxidative stress is also involved in tumorigenesis by activation of different MAP kinase pathways including MMP induction. Oxidative stress is involved in cancer by changing the activity and expression of regulatory proteins especially MMPs. Epidemiological studies have shown that high intake of fruits that rich in antioxidants is associated with a lower cancer incidence. Evidence indicates that some antioxidants inhibit the growth of malignant cells by inducing apoptosis and inhibiting the activity of MMPs. This review is discussed in six subchapters, as follows. AbstractThe process of carcinogenesis is tightly regulated by antioxidant enzymes and matrix degrading enzymes, namely, matrix metalloproteinases (MMPs). Degradation of extracellular matrix (ECM) proteins like collagen, proteoglycan, laminin, elastin and fibronectin is considered to be the prerequisite for tumor invasion and metastasis. MMPs can degrade essentially all of the ECM components and, most MMPs also substantially contribute to angiogenesis, differentiation, proliferation and apoptosis. Hence, MMPs are important regulators of tumor growth both at the primary site and in distant metastases; thus the enzymes are considered as important targets for cancer therapy. The implications of MMPs in cancers are no longer mysterious; however, the mechanism of action is yet to be explained. Herein, our major interest is to clarify how MMPs are tied up with gastrointestinal cancers. Gastrointestinal cancer is a variety of cancer types, including the cancers of gastrointestinal tract and organs, i.e., esophagus, stomach, biliary system, pancreas, small intestine, large intestine, rectum and anus. The activity of MMPs is regulated by its endogenous inhibitor tissue inhibitor of metallopro-

show abstract

“…MMP7 genetic variation and cancer susceptibility have been studied mainly in two promoter polymorphisms (Ϫ181A3 G and Ϫ153C3 T) that have been found to affect protein expression (10,23). Most of the studies showed positive associations of Ϫ181GG genotype with the risk of cancer development among different populations (13).…”

Section: Discussionmentioning

confidence: 99%

“…However, the molecular basis of MMP7 up-regulation in gastric cancer remains unclear. Single base pair substitutions in the MMP promoter may create or abolish the transcription factor-binding site, thereby modifying transcriptional activity (23,24). Two common functional SNPs (Ϫ181A3 G and Ϫ153C/T) located in the MMP7 promoter region known to influence gene expression were studied in several disease conditions, including hypercholesterolemia, idiopathic pulmonary fibrosis, and several cancer types (e.g.…”

mentioning

confidence: 99%

Association of MMP7 −181A→G Promoter Polymorphism with Gastric Cancer Risk

Kesh

Subramanian

Ghosh

et al. 2015

Journal of Biological Chemistry

View full text Add to dashboard Cite

Background: Effect of tobacco carcinogen nicotine on MMP7 transcription and gastric cancer risk remains unknown. Results: Preferential binding of pCREB, induced by nicotine, to G-allele promoter enhanced the transcription and thus aggravated gastric cancer risk. Conclusion: Nicotine shows an additive effect over MMP7 GG genotype toward gastric cancer risk. Significance: These findings may help in the clinical management of gastric cancer.

show abstract

Single-nucleotide polymorphisms of matrix metalloproteinases and their inhibitors in gastrointestinal cancer

Cited by 24 publications

References 104 publications

Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes

Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes

Matrix metalloproteinases and gastrointestinal cancers: Impacts of dietary antioxidants

Association of MMP7 −181A→G Promoter Polymorphism with Gastric Cancer Risk

Contact Info

Product

Resources

About