Single nucleotide polymorphisms of TNFAIP3 are associated with systemic lupus erythematosus in Han Chinese population

Abstract

The polymorphisms of tumour necrosis factor alpha-induced protein 3 (TNFAIP3) have been found to associate with several autoimmune diseases. This study aimed to explore the association of single nucleotide polymorphisms (SNPs) of TNFAIP3 gene with systemic lupus erythematosus (SLE) in Han Chinese. Thirty-two SNPs were genotyped in 284 patients with SLE and 630 controls using the ligation detection reaction (LDR) method. The quality control steps and statistical analyses were performed using the PLINK 1.07 package and HAPLOVIEW software. We found that 13 SNPs in TNFAIP3 showed significant association with SLE (P < 1.85 × 10(-3)), and all of them were in high linkage disequilibrium (LD). After conditioning on the SNP rs2230926, other 12 SNPs did not show association (P > 0.27). All 13 SNPs showed most significant association in the dominant model. In haplotype analysis, a long risk SNP haplotype (GCCCGTGTCATGG) showed most significant association (P = 1.00 × 10(-4)). In conclusion, our data suggest that TNFAIP3 is a susceptible gene for SLE in the Han Chinese population.

<p>Tumor Necrosis Factor Alpha-Induced Proteins in Malignant Tumors: Progress and Prospects</p>

“…TNFAIP3 protein as a zinc finger protein and ubiquitin shearing enzyme can suppress activated NF-κB signal pathway and induce apoptosis of TNF by activating ubiquitin ligase and ubiquitinase. 24 Some studies showed that TNFAIP3 could play an important role in immune and inflammatory responses mediated by cytokines. [24][25][26]…”

Associations between TNFAIP3 gene polymorphisms and systemic lupus erythematosus risk: an updated meta‐analysis

“…Among these, 13 did not study the association of TNFAIP3 gene polymorphisms with SLE, 1 article for data duplication (31). Thus, 20 articles met our inclusion criteria (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30). Among the eligible articles, two articles (22,24) contained data on two or more different groups, and these groups were analyzed independently.…”

“…Among the eligible articles, two articles (22,24) contained data on two or more different groups, and these groups were analyzed independently. Finally, a total of 23 studies in 20 articles including 18,501 patients with SLE and 30,435 healthy controls were considered in our meta-analysis (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30). There were 20 studies on rs2230926 (12-27, 30), 10 studies on rs5029939 (11,13,17,22,23,26,(28)(29)(30), 8 studies on rs3757173 (16,17,22,27,30), 5 studies on rs5029937 (20,22,26,30).…”

“…This is the first identified with rheumatoid arthritis . Over the last decade, numerous studies have investigated the relationship between TNFAIP3 gene polymorphisms association with SLE .…”

“…Fan et al (33) and Lee and Song (34) both performed meta-analysis to assess the association between TNFAIP3 gene polymorphisms and SLE risk, but these meta-analysis included only two and eight studies, respectively. More studies concerning the association between SNPs and SLE risk have been reported in recent years (19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30). Thus, it seems necessary to perform a meta-analysis that includes the most updated data to investigate the relationships between TNFAIP3 gene polymorphisms and the risk of SLE.…”