Single Nucleotide Polymorphisms (SNPs)

Batra, Jyotsna; Srinivasan, Srilakshmi; Clements, Judith A.

doi:10.1007/978-1-4899-8050-2_5

Cited by 3 publications

(1 citation statement)

References 123 publications

(80 reference statements)

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“…Hypermethylation of the hypermethylated in cancer 1 promoter has been revealed to be present in 17% of pediatric patients with OS ( 13 ). In addition, genetic variations, particularly single nucleotide polymorphisms, may contribute to cancer risk and progression ( 14 ). Copy number variations across the whole genome, including deletions, amplifications and duplications, are associated with OS tumorigenesis ( 15 ).…”

Section: Introductionmentioning

confidence: 99%

Screening of candidate key genes associated with human osteosarcoma using bioinformatics analysis

Zhang

Gao

2017

Oncology Letters

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The aim of the present study was to identify the key genes associated with osteosarcoma (OS) using a bioinformatics approach. Microarray data (GSE36004) was downloaded from the Gene Expression Omnibus database, including 19 OS cell lines and 6 normal controls. Differentially expressed genes (DEGs) in the OS cell lines were identified using the Limma package, and differentially methylated regions were screened with methyAnalysis in R. Copy number analysis was performed and genes with copy number gains/losses were further screened using DNAcopy and cghMCR packages. Functional enrichment analyses were performed using the Database for Annotation, Visualization and Integrated Discovery online tool, and protein-protein interactions were identified based on information obtained from the Search Tool for the Retrieval of Interacting Genes database. A total of 47 downregulated genes were screened in hyper-methylated regions, including the fragment crystallizable (Fc) region of immunoglobulin E, high affinity I, receptor for; γ polypeptide (FCER1G), leptin (LEP) and feline Gardner-Rasheed sarcoma viral oncogene homolog (FGR). In addition, a total of 17 upregulated genes, including the TPase family, AAA domain containing 2 (ATAD2) and cyclin-dependent kinase 4 (CDK4), exhibited copy number gains, while 5 downregulated genes, including Rho GTPase activating protein 9 (ARHGAP9) and major histocompatibility complex, class II, DO α (HLA-DOA), exhibited copy number losses. These results indicate that hyper-methylation of FCER1G, LEP, and FGR may serve a crucial function in the development of OS. In addition, copy number alterations of these DEGs, including ATAD2, CDK4, ARHGAP9 and HLA-DOA, may also contribute to OS progression. These DEGs may be candidate targets for the diagnosis and treatment of this disease.

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Section: Introductionmentioning

confidence: 99%

Screening of candidate key genes associated with human osteosarcoma using bioinformatics analysis

Zhang

Gao

2017

Oncology Letters

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Genetic Testing for Hereditary Breast and Ovarian Cancer

Roche¹,

Petrucelli²

2016

Advanced Health Assessment of Women

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Advances in Molecular Marker Technology and their Significance in Plant Improvement Strategies

Kamal Meena,

Vardhan Singh Shekhawat,

Chand

et al. 2023

Recent Trends in Plant Breeding and Genetic Improvement

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Molecular markers are powerful tools that have revolutionized plant improvement strategies by allowing breeders to select plants with desirable traits at an early stage. These markers are specific DNA sequences that can be used to identify genes responsible for important plant traits such as disease resistance, drought tolerance, and yield potential. Advances in molecular marker technology have greatly improved their efficiency and accuracy, making them an essential tool in plant breeding programs. One such advance is the development of high-throughput sequencing technologies, which allow for the rapid and cost-effective identification of large numbers of molecular markers. Additionally, new marker systems such as SNPs have been developed, which offer a high level of accuracy and reproducibility. The use of molecular markers in plant breeding has several advantages over traditional breeding methods. For instance, markers can be used to identify desirable traits that are not easily observable, or to select plants with multiple desirable traits at once. This has led to the development of new and improved crop varieties that are more resistant to diseases, better adapted to changing environmental conditions, and have higher yields. In conclusion, the continued development of molecular marker technology is crucial for the advancement of plant improvement strategies.

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Single Nucleotide Polymorphisms (SNPs)

Cited by 3 publications

References 123 publications

Screening of candidate key genes associated with human osteosarcoma using bioinformatics analysis

Screening of candidate key genes associated with human osteosarcoma using bioinformatics analysis

Genetic Testing for Hereditary Breast and Ovarian Cancer

Advances in Molecular Marker Technology and their Significance in Plant Improvement Strategies

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