Single nucleotide polymorphisms, variable number tandem repeats and allele influence on serotonergic enzyme modulators for aggressive and suicidal behaviors: A review

Xiang, Chunchen; Liu, Shaojiang; Fan, Yutong; Wang, Xinyue; Yang, Jia; Li, Liang; Cong, Shuyan; Han, Fang

doi:10.1016/j.pbb.2019.03.008

Cited by 15 publications

(20 citation statements)

References 120 publications

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“…Several genes related to serotonin function have been tested for associations with aggression, including variants of the genes encoding for serotonin 1B and 2A (5-HT 1B , 5-HT 2A ) receptors and tryptophan hydroxylase (TPH2), but sample sizes have been small and the outcomes conflicting (15,16). The serotonin transporter (5-HTT) linked polymorphic region (5-HTTLPR) is a polymorphism of the gene coding for 5-HTT and is associated with brain serotonin levels (17).…”

Section: Serotonin Related Genetic Modifiersmentioning

confidence: 99%

The Modulatory Role of Serotonin on Human Impulsive Aggression

Cunha-Bang

Knudsen

2021

Biological Psychiatry

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Section: Serotonin Related Genetic Modifiersmentioning

confidence: 99%

The Modulatory Role of Serotonin on Human Impulsive Aggression

Cunha-Bang

Knudsen

2021

Biological Psychiatry

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“…Although they are found in many eukaryote species, present day interest has focused on their role in hominid evolution and their contribution to the development of human-specific traits in the evolution of modern humans and in particular neural function. 2 – 4 In modern humans, TR DNA has been associated both with traits such as aggression and addictive behaviors, reviewed by literature 5 – 8 and implicated in the increased susceptibility to, and risk of developing, a wide variety of neurological diseases such as motor neuron disease 9 – 11 and Alzheimer’s disease 12 , 13 mental health conditions such as bipolar disorder, depression, and schizophrenia. 14 , 15 To date, 1584 such repeats have been found to be human specific and it has been proposed that they contribute to human-specific traits.…”

Section: Consequences and Genetic Nature Of Tandem Repeat Dnamentioning

confidence: 99%

Variable number tandem repeats – Their emerging role in sickness and health

Marshall

Lopez

Pfaff

et al. 2021

Exp Biol Med (Maywood)

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Understanding the mechanisms regulating tissue specific and stimulus inducible regulation is at the heart of understanding human biology and how this translates to wellbeing, the ageing process, and disease progression. Polymorphic DNA variation is superimposed as an extra layer of complexity in such processes which underpin our individuality and are the focus of personalized medicine. This review focuses on the role and action of repetitive DNA, specifically variable number tandem repeats and SINE-VNTR- Alu domains, highlighting their role in modification of gene structure and gene expression in addition to their polymorphic nature being a genetic modifier of disease risk and progression. Although the literature focuses on their role in disease, it illustrates their potential to be major contributors to normal physiological function. To date, these elements have been under-reported in genomic analysis due to the difficulties in their characterization with short read DNA sequencing methods. However, recent advances in long read sequencing methods should resolve these problems allowing for a greater understanding of their contribution to a host of genomic and functional mechanisms underlying physiology and disease.

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“…Abnormal MAO-A activity has been reported in several neuropsychiatric disorders, including schizophrenia (Sun et al, 2012), depression (Rivera et al, 2009) or Alzheimer's disease (Takehashi et al, 2002) and MAO inhibitors are used as an effective treatment for depression (Thomas et al, 2015). Moreover, some MAO-A polymorphisms have been related with aggressive behaviour (Frau et al, 2019;Xiang et al, 2019).…”

Section: Monoamino Oxidase a Enzymementioning

confidence: 99%

Alternative splicing in serotonergic system: Implications in neuropsychiatric disorders

2019

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Background: The serotonergic system is a key component of physiological brain function and is essential for proper neurological activity. Numerous neuropsychiatric disorders are associated with deregulation of the serotonergic system. Accordingly, many pharmacological treatments are focused on modulation of this system. While providing a promising line of therapeutic moderation, these approaches may be complicated due to the presence of alternative splicing events for key genes in this pathway. Alternative splicing is a co-transcriptional process by which different mRNA transcripts can be produced from the same gene. These different isoforms may have diverse activities and functions, and their relative balance is often critical for the maintenance of homeostasis. Alternative splicing greatly increases the production of proteins, augmenting cell plasticity, and provides an important control point for regulation of gene expression. Aim: The objective of this narrative review is to discuss the potential impact of alternative splicing of different components of the serotonergic system and speculate on their involvement in several neuropsychiatric disorders. Conclusions: The specific role of each isoform in disease and their relative activities in the signalling pathways involved are yet to be determined. We need to gain a better understanding of the basis of alternative isoforms of the serotonergic system in order to fully understand their impact and be able to develop new effective pharmacological isoform-specific targets.

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Single nucleotide polymorphisms, variable number tandem repeats and allele influence on serotonergic enzyme modulators for aggressive and suicidal behaviors: A review

Cited by 15 publications

References 120 publications

The Modulatory Role of Serotonin on Human Impulsive Aggression

The Modulatory Role of Serotonin on Human Impulsive Aggression

Variable number tandem repeats – Their emerging role in sickness and health

Alternative splicing in serotonergic system: Implications in neuropsychiatric disorders

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