Single-nucleus RNA and multiomics in situ pairwise sequencing reveals cellular heterogeneity of the abnormal ligamentum teres in patients with developmental dysplasia of the hip

Zhao, Zhenhui; Fan, Chuiqin; Wang, Shiyou; Wang, Haoyu; Deng, Hansheng; Zeng, Shuaidan; Tang, Shengping; Li, Li; Xiong, Zhu; Qiu, Xin

doi:10.1016/j.heliyon.2024.e27803

Heliyon

2024

DOI: 10.1016/j.heliyon.2024.e27803

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Single-nucleus RNA and multiomics in situ pairwise sequencing reveals cellular heterogeneity of the abnormal ligamentum teres in patients with developmental dysplasia of the hip

Zhenhui Zhao,

Chuiqin Fan,

Shiyou Wang

et al.

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Advances in Molecular Research on Hip Joint Impingement—A Vascular Perspective

Huzum,

Hînganu,

Huzum

et al. 2024

Biomolecules

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With the rise in longevity within the population, medicine continues to encounter fresh hurdles necessitating prompt actions, among which are those associated with hip joint aging. Age-related arthropathies encompass damage to bones’ articulating extremities and their supporting structures, such as articular cartilage, and alterations in the quantity and quality of synovial fluid. This study aims to summarize the biomolecular methods of hip joint evaluation focused on its vascularization, using data correlated with biomolecular research on other joints and tissues, in order to reach an objective opinion of the study prospects in this field. Following a retrospective study on most modern biomolecular research methods on the synovium, the capsule, and the articular cartilage of the hip joint, we have hereby concretized certain future research directions in this field that will improve the qualitative and morphofunctional management of the hip joint at an advanced age, even within population categories at risk of developing various degenerative joint pathologies.

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Advances in Molecular Research on Hip Joint Impingement—A Vascular Perspective

Huzum,

Hînganu,

Huzum

et al. 2024

Biomolecules

View full text Add to dashboard Cite

show abstract

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Single-nucleus RNA and multiomics in situ pairwise sequencing reveals cellular heterogeneity of the abnormal ligamentum teres in patients with developmental dysplasia of the hip

Cited by 1 publication

References 65 publications

Advances in Molecular Research on Hip Joint Impingement—A Vascular Perspective

Advances in Molecular Research on Hip Joint Impingement—A Vascular Perspective

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