Single or Double Site Cannuation for Veno-Venous Ecmo in Severe Obese Patient?

doi:10.20431/2455-9792.0104004

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…Both factors contribute to a limit in ECMO flow. Alternative cannulas, e. g. the Avalon cannula, are used for walking ECMO in a clinical setting and enable higher blood flow and consecutive oxygen transfer, but application is limited due to high dislocation risk [36][37][38]. We therefore conclude that the cannula was not well chosen for the intended use.…”

Section: In-vivo Evaluationmentioning

confidence: 97%

In-vitro and In-vivo Feasibility Study for a Mobile VV-ECMO and ECCO2R System

Strudthoff¹,

Lüken²,

Jansen³

et al. 2021

Preprint

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Extracorporeal membrane oxygenation (ECMO) is an established rescue therapy for patients with chronic respiratory failure waiting for lung transplantation (LTx). The therapy inherent immobilization may result in fatigue, consecutive deteriorated prognosis and even lost eligibility for transplantation. We conducted a feasibility study on a novel system designed for the deployment of a mobile ECMO device, enabling physical exercise of awake patients prior to LTx. The system comprises a novel mobile oxygenator with a directly connected blood pump, a double lumen cannula, gas blender and supply, as well as control, and energy management. In-vitro experiments included tests regarding performance, efficiency, and blood damage. A reduced system was tested in vivo for feasibility using a novel large animal model. Six anesthetized pigs were first positioned in supine position, followed by a 45° angle, simulating an upright position of the patients. We monitored performance and vital parameters. All in-vitro experiments showed good performance for the respective subsystems and the integrated system. The acute invivo trials of 8h duration confirmed the results. The novel mobile ECMO-system enables adequate oxygenation and decarboxylation sufficient for, e.g., physical exercise of designated LTx-recipients. These results are promising and suggest further preclinical studies on safety and efficacy to facilitate translation into clinical application.

show abstract

Section: In-vivo Evaluationmentioning

confidence: 97%

In-vitro and In-vivo Feasibility Study for a Mobile VV-ECMO and ECCO2R System

Strudthoff¹,

Lüken²,

Jansen³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Both factors contribute to a limit in ECMO flow. Alternative cannulas, e.g., the Avalon cannula, are used for walking ECMO in a clinical setting and enable higher blood flow and consecutive oxygen transfer, but the application is limited due to high cannula migration and dislocation risk with severe complications [38][39][40][41][42][43][44]. We therefore conclude that the cannula was not well chosen for the intended use.…”

Section: In Vivo Evaluationmentioning

confidence: 99%

In Vitro and In Vivo Feasibility Study for a Portable VV-ECMO and ECCO2R System

et al. 2022

View full text Add to dashboard Cite

Extracorporeal membrane oxygenation (ECMO) is an established rescue therapy for patients with chronic respiratory failure waiting for lung transplantation (LTx). The therapy inherent immobilization may result in fatigue, consecutive deteriorated prognosis, and even lost eligibility for transplantation. We conducted a feasibility study on a novel system designed for the deployment of a portable ECMO device, enabling the physical exercise of awake patients prior to LTx. The system comprises a novel oxygenator with a directly connected blood pump, a double-lumen cannula, gas blender and supply, as well as control and energy management. In vitro experiments included tests regarding performance, efficiency, and blood damage. A reduced system was tested in vivo for feasibility using a novel large animal model. Six anesthetized pigs were first positioned in supine position, followed by a 45° angle, simulating an upright position of the patients. We monitored performance and vital parameters. All in vitro experiments showed good performance for the respective subsystems and the integrated system. The acute in vivo trials of 8 h duration confirmed the results. The novel portable ECMO-system enables adequate oxygenation and decarboxylation sufficient for, e.g., the physical exercise of designated LTx-recipients. These results are promising and suggest further preclinical studies on safety and efficacy to facilitate translation into clinical application.

show abstract

Single or Double Site Cannuation for Veno-Venous Ecmo in Severe Obese Patient?

Cited by 2 publications

References 6 publications

In-vitro and In-vivo Feasibility Study for a Mobile VV-ECMO and ECCO2R System

In-vitro and In-vivo Feasibility Study for a Mobile VV-ECMO and ECCO2R System

In Vitro and In Vivo Feasibility Study for a Portable VV-ECMO and ECCO2R System

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