Single or multiple embryo transfer following <i>in vitro</i> fertilisation for improved neonatal outcome: A systematic review of the literature

Dare, Marianna R; Crowther, Caroline A; Dodd, Jodie M; Norman, Robert J.

doi:10.1111/j.1479-828x.2004.00243.x

Cited by 18 publications

(4 citation statements)

References 46 publications

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“…The rationale for favouring DET over SET, until recently, has been that the transfer of two or more embryos results in a higher clinical pregnancy rate than the transfer of only one embryo, especially in younger women 15 . However, a higher clinical pregnancy rate does not mean better perinatal outcomes for the baby.…”

Section: Discussionmentioning

confidence: 99%

Perinatal outcomes after assisted reproductive technology treatment in Australia and New Zealand: single versus double embryo transfer

Wang

Sullivan

Healy

et al. 2009

Medical Journal of Australia

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Objective: To compare the perinatal outcomes of babies conceived by single embryo transfer (SET) with those conceived by double embryo transfer (DET). Design, setting and participants: A retrospective population‐based study of embryo transfer cycles in Australia and New Zealand between 2002 and 2006, using data from the Australia and New Zealand Assisted Reproduction Database. Main outcome measures: Proportion of SET procedures; comparison of SET and DET procedures with respect to multiple births, low birthweight (LBW), preterm birth and fetal death. Results: The proportion of SET procedures has increased from 28.4% in 2002 to 32.0% in 2003, 40.5% in 2004, 48.2% in 2005 and 56.9% in 2006. The multiple birth rate for all babies conceived by SET (4.0%) was 10 times lower than for those conceived by DET (39.1%) (P < 0.01). The average birthweight for all liveborn babies conceived by SET (3290 g) was higher than for those conceived by DET (2934 g) (P < 0.01). The preterm birth rate of all DET‐conceived babies (30.3%) was higher than for SET‐conceived babies (12.3%) (adjusted odds ratio [AOR], 3.19 [95% CI, 3.01–3.38]). All babies conceived by DET were more likely to be stillborn than those conceived by SET (AOR, 1.49 [95% CI, 1.21–1.82]). Singletons conceived by DET were more likely to be born preterm than singletons conceived by SET (AOR, 1.13 [95% CI, 1.05–1.22]). Liveborn singletons conceived by DET were 15% more likely to have LBW than liveborn singletons conceived by SET (AOR, 1.15 [95% CI, 1.05–1.26]). There was no significant difference in fetal death rate between DET‐ and SET‐conceived singletons. Conclusion: The increase in proportion of SET procedures has resulted in a lower rate of multiple births and in better perinatal outcomes in Australian and New Zealand assisted reproduction programs.

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Section: Discussionmentioning

confidence: 99%

Perinatal outcomes after assisted reproductive technology treatment in Australia and New Zealand: single versus double embryo transfer

Wang

Sullivan

Healy

et al. 2009

Medical Journal of Australia

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“…They compared the outcome of double embryo transfer with that of three-or-more embryo transfer. They found that the transfer of two embryos was associated with a lower incidence of live birth at term, clinical pregnancy, multiple pregnancy and multiple birth, twin birth, triplet or higher order pregnancy, and triplet or higher order births (Dare et al ., 2004). This difference might be explained by the improvement in technology during the last ten years.…”

Section: Discussionmentioning

confidence: 99%

Transfer of more than two embryos, regardless of the age of the female partner, is not beneficial for neither the mothers nor the babies: lessons from the Latin American Registry of Assisted Reproductive Techniques

Schwarze

Crosby

2017

JBRA Assisted Reproduction

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ObjectiveART has helped millions of infertile couples worldwide to overcome their childlessness. These successes have been accompanied by an increase in multiple deliveries, and perinatal complications associated. The explanation for this complication is the transfer of more than one embryo, to increase the odds of delivery. Our objective was to compare the outcome of elective dual embryo transfer (eDET) to that of the transfer of more than two embryos without embryo cryopreservation (TET), terms of delivery rate and multiple delivery.MethodsWe analyzed the data registered by 155 clinics members of the RLA: 11,024 eDET and 10,634 TET.ResultsThe delivery rate was significantly higher when eDET was performed than when TET was performed (40.24% and 26.98%, p < 0.001). Also, the ratio of twin deliveries was higher in eDET (25.80% and 20.56%, p < 0.001). However, the ratio of triplets and more deliveries was higher in TET than in eDET (2.34%and 0.52%, p < 0.001). These findings were consistent across the different age categories of the female partner.ConclusionOur findings suggest that eDET was associated with a statistically significant better delivery rate per embryo transfer, and lower ratio of triplet-and-higher deliveries, regardless of the woman’s age. Therefore, there is no evidence that supports the transfer of more than two embryos.

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“…Outro grande desafio na reprodução assistida é a tentativa de se minimizar a incidência de gestação múltipla secun-dária aos tratamentos. Assim, nas técnicas de fertilização in vitro, têm-se tentado cada vez mais a transferência de um embrião único (Dare et al, 2004). E a forma para se conseguir isso é a transferência de embriões no estágio de blastocisto, pois assim, há uma melhor seleção embrionária.…”

Section: Introductionunclassified

Outcome of Blastocysts Vitrification

Cota¹,

Lages²,

Mendonça³

et al. 2011

JBRA

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Resumoobjetivo: avaliar os resultados da técnica de vitrificação para o congelamento de blastocistos humanos, na Clínica Pró Criar. métodos: Foi realizado um estudo observacional, retrospectivo e descritivo, onde foram avaliados os prontuários das pacientes que se submeteram a um ciclo de congelamento e descongelamento de blastocistos vitrificados durante o período de janeiro/2007 a maio/2010. Resultados: Foram avaliados 292 ciclos de congelamento e descongelamento de blastocisto, sendo que a idade média das mulheres foi de 34,35 anos. O número médio de blastocistos vitrificados/desvitrificados por paciente foi de 2,08 ± 0.87, totalizando 604 blastocistos descongelados. Desses embriões descongelados, 482 blastocistos sobreviveram, sendo a taxa de sobrevivência do blastocisto de 80%. Nos 269 ciclos em que houve transferência, uma média de 1,63 ± 0.77 blastocistos foram transferidos por paciente. Das 292 pacientes, 57,53% tiveram os blastocistos congelados no dia 5 e 42,47% tiveram o congelamento no dia 6. A taxa global de gravidez por ciclo de descongelamento foi de 44,5% e a taxa de gravidez clínica por transferência foi 48%. Quando realizada a comparação dos resultados segundo o dia de congelamento (dia 5 x dia 6) não foi encontrado diferença significativa em relação à taxa de gravidez. Conclusão: Pode-se concluir que o método de vitrificação de blastocistos é uma técnica eficiente, com altas taxas de sobrevivência, possibilitando o armazenamento dos embriões excedentes com boas taxas de gravidez em ciclos de descongelamento.

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Single or multiple embryo transfer following in vitro fertilisation for improved neonatal outcome: A systematic review of the literature

Cited by 18 publications

References 46 publications

Perinatal outcomes after assisted reproductive technology treatment in Australia and New Zealand: single versus double embryo transfer

Perinatal outcomes after assisted reproductive technology treatment in Australia and New Zealand: single versus double embryo transfer

Transfer of more than two embryos, regardless of the age of the female partner, is not beneficial for neither the mothers nor the babies: lessons from the Latin American Registry of Assisted Reproductive Techniques

Outcome of Blastocysts Vitrification

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