Single-organ gallbladder vasculitis: Characterization and distinction from systemic vasculitis involving the gallbladder. An analysis of 57 patients

Hernández‐Rodríguez, José; Tan, Carmela D.; Rodríguez, E. René; Hoffman, Gary S.

doi:10.1016/j.lpm.2013.02.209

Cited by 9 publications

(9 citation statements)

References 30 publications

(93 reference statements)

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“…In terms of the location of abdominal pain, right upper quadrant pain has been reported as the initial presentation of PAN in numerous reports 4 11 16 18–20. In contrast to our patient, most cases were diagnosed after cholecystectomy for acalculous cholecystitis in which tissue analysis disclosed PAN 11 18 19. Gallbladder involvement can cause right upper quadrant pain and also hepatic aneurysm rupture 20 21…”

Section: Discussioncontrasting

confidence: 65%

Right upper quadrant abdominal pain as the initial presentation of polyarteritis nodosa

2017

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Polyarteritis nodosa (PAN) is a necrotising vasculitis that involves medium and small vessels. PAN generally presents with constitutional, cutaneous, neurological, renal and gastrointestinal manifestations. However, PAN initially involving a single organ/system is uncommon. Here, we present a 42-year-old man who was hospitalised because of severe right upper quadrant abdominal pain that started 2 months before. Physical examination was remarkable for right upper quadrant abdominal tenderness. Abdominopelvic CT showed lymphadenopathy but no hepatic, gallbladder, pancreatic, intestinal or renal abnormalities. Abdominal angiography showed multiple small aneurysms located in the jejunal and hepatic arteries characteristic of PAN. He had a prompt and remarkable response to high-dose corticosteroids and oral cyclophosphamide. Our case, together with other reports, suggests that PAN should be considered in patients presenting with right upper abdominal pain. Timely diagnosis and treatment reduce the overall morbidity and mortality of the disease.

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Section: Discussioncontrasting

confidence: 65%

Right upper quadrant abdominal pain as the initial presentation of polyarteritis nodosa

2017

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“…Vasculitis or vascular occlusion have also been raised as possible etiologies of acute emphysematous cholecystitis. May and Strong [10] considered the possibility of endarteritis obliterans or cystic artery occlusion in their 1971 article, whereas Hernandez-Rodriguez et al discussed single-organ vasculitis [11]. The microscopic pathology on our patient did demonstrate vasculitis present within areas of abscess formation; unfortunately which developed first cannot be definitively determined.…”

Section: Discussion and Literature Reviewmentioning

confidence: 62%

Acalculous Perforated Hemorrhagic Emphysematous Cholecystitis Caused byClostridium perfringensin a Patient with Myeloma Taking Daratumumab

BerndtsonAllison

HamelMichelle

CostantiniTodd

et al. 2017

Surgical Infections Case Reports

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Background: Acute calculous cholecystitis is a common disease entity familiar to every surgeon, however, variations such as acalculous cholecystitis, hemorrhagic cholecystitis, and emphysematous or gangrenous cholecystitis are rare. Diagnosis is more difficult and delays increase patient morbidity. Case Presentation: We present the case of a 75-year-old female Caucasian with multiple myeloma, undergoing treatment with daratumumab and dexamethasone, who was diagnosed with acute acalculous, emphysematous, perforated, and hemorrhagic cholecystitis. Active hemorrhage was demonstrated via contrast blush on computed tomography (CT) scan. She was treated expeditiously and recovered well. Cultures demonstrated a polymicrobial infection, including Clostridium perfringens. Conclusion: This is a complex case with unclear initial etiology, likely exacerbated by growth of Clostridium perfringens. It is possible that the patient's immunocompromised state contributed to infection that then lead to gallbladder emphysema, perforation, and hemorrhage. Thus, the clinician should be aware of the possibility of complicated cholecystitis in the immunocompromised patient, even in the absence of neutropenia, to avoid missing devastating complications of perforation or hemorrhage.

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“…is could be another clue that comes to an agreement with the benign course of the patients with EBV cholecystitis, such as described in our patient. In addition, single organ gallbladder vasculitis is a well-described form of localised vasculitis [52]. Viruses such as HBV and HCV have been identified as causative agents in some of these cases.…”

Section: Discussionmentioning

confidence: 99%

Acute Acalculous Cholecystitis Associated with Epstein–Barr Infection: A Case Report and Review of the Literature

Ntelis

Mazarakis

Sapountzis

et al. 2020

Case Reports in Medicine

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The most common cause of acute cholecystitis (ACC) is cholelithiasis. Acute acalculous cholecystitis (AAC) is well documented in the literature related with critical illness, but viral causes such as cytomegalovirus (CMV) and Epstein–Barr virus (EBV) have also been reported. We present a rare manifestation of EBV infection, reporting a case of a 15-year-old female suffering from acute acalulous cholecystitis, and we review the relevant literature. Clinicians should be aware of this rare complication of EBV infection and properly exclude it in young patients with cholecystitis.

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Single-organ gallbladder vasculitis: Characterization and distinction from systemic vasculitis involving the gallbladder. An analysis of 57 patients

Cited by 9 publications

References 30 publications

Right upper quadrant abdominal pain as the initial presentation of polyarteritis nodosa

Right upper quadrant abdominal pain as the initial presentation of polyarteritis nodosa

Acalculous Perforated Hemorrhagic Emphysematous Cholecystitis Caused byClostridium perfringensin a Patient with Myeloma Taking Daratumumab

Acute Acalculous Cholecystitis Associated with Epstein–Barr Infection: A Case Report and Review of the Literature

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