Single-particle spectroscopy for functional nanomaterials

Zhou, Jiajia; Chizhik, Alexey I.; Chu, Steven; Jin, Dayong

doi:10.1038/s41586-020-2048-8

Cited by 204 publications

(140 citation statements)

References 125 publications

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“…Recent years have witnessed the development of alternative ways to measure QY that are based on the ratio of the radiative ( k r ) to the non-radiative ( k nr ) de-excitation rate of a fluorophore 8 . Modulation of either the radiative or the non-radiative rate can be monitored by measuring the total rate ( k r + k nr ), i.e., the inverse excited-state lifetime.…”

Section: Introductionmentioning

confidence: 99%

Absolute quantum yield measurements of fluorescent proteins using a plasmonic nanocavity

et al. 2020

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One of the key photophysical properties of fluorescent proteins that is most difficult to measure is the quantum yield. It describes how efficiently a fluorophore converts absorbed light into fluorescence. Its measurement using conventional methods become particularly problematic when it is unknown how many of the proposedly fluorescent molecules of a sample are indeed fluorescent (for example due to incomplete maturation, or the presence of photophysical dark states). Here, we use a plasmonic nanocavity-based method to measure absolute quantum yield values of commonly used fluorescent proteins. The method is calibration-free, does not require knowledge about maturation or potential dark states, and works on minute amounts of sample. The insensitivity of the nanocavity-based method to the presence of non-luminescent species allowed us to measure precisely the quantum yield of photo-switchable proteins in their on-state and to analyze the origin of the residual fluorescence of protein ensembles switched to the dark state.

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Section: Introductionmentioning

confidence: 99%

Absolute quantum yield measurements of fluorescent proteins using a plasmonic nanocavity

et al. 2020

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“…976 nm excitations. These results suggest UCEL mode could be broadly applied to a variety of UCNP core concentrations 36 and under a large dynamic range of excitation power densities 37 , suitable for both ensemble and single nanoparticle applications 38 .…”

Section: Remarkable Deep-uv Enhancement To Investigate the Unusual Dmentioning

confidence: 88%

Upconverted excitation energy lock-in for deep-ultraviolet enhancement

Wei

Wang

et al. 2020

Preprint

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Photon upconversion of near-infrared (NIR) irradiation into deep-ultraviolet (UV) emission offers many exciting opportunities for drug release in deep tissues, photodynamic therapy, solid-state lasing, energy storage, and photocatalysis. However, NIR-to-deep-UV upconversion remains a daunting challenge due to low quantum efficiency. Here, we report an unusual six-photon upconversion process in Gd3+/Tm3+-codoped nanoparticles comprising a heterogeneous, core-multishell nanostructure. This multishell design efficiently suppresses energy consumption induced by interior energy traps, maximizes cascade sensitizations of the NIR excitation, and promotes upconverted deep-UV emission from high-lying excited states. We released the intense six-photon-upconverted UV emissions at 253 nm under 808-nm excitation. This work provides new insight into mechanistic understanding of the upconversion process within the heterogeneous architecture, while offering exciting opportunities for developing nanoscale deep-UV emitters that can be remotely controlled in deep tissues upon NIR illumination.

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“…[187][188][189] The intrinsic fluorescent properties of NDs with high photostability may be exploited further for biomedical imaging and clinical diagnosis. [190,191] As previously mentioned, NDs are also being clinically evaluated for root canal therapy. Though fullerenes were among the first types of carbon nanomaterials investigated for biomedical applications, they are now much less considered, despite some potential for drug delivery.…”

Section: Clinical Translation Of Carbon Nanomaterialsmentioning

confidence: 99%

Carbon Nanomaterials Applied for the Treatment of Inflammatory Diseases: Preclinical Evidence

Soltani

Guo

Bianco

et al. 2020

Advanced Therapeutics

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In the last decade, graphene‐based nanomaterials and carbon dots have joined the family of carbon materials mainly composed of graphite, diamond, fullerene, and carbon nanotubes. Carbon nanomaterials have been widely exploited in various fields from electronics and materials science to nanomedicine. The studies on their effect on the immune system have revealed that they possess intrinsic anti‐inflammatory properties, reducing the production of proinflammatory cytokines and modulating immune cell maturation. In addition, their large specific surface area associated with high biocompatibility allows their use as carriers for the delivery of anti‐inflammatory agents. They can also contribute to the diagnosis of inflammatory diseases as biosensors for low‐limit detection and quantification of inflammation‐related biomarkers in body fluids and tissues allowing to monitor the concentration of drugs in urine and guide personalized drug usage. Finally, they are used as adsorbents for blood plasma purification in the clinical treatment of sepsis through efficient removal of certain cytokines. This review focuses on the intrinsic anti‐inflammatory properties of carbon nanomaterials. An overview is provided on their use as carriers of anti‐inflammatory drugs, as biosensors, and for blood purification in the context of inflammatory diseases. The potential of carbon nanomaterials for clinical translation is also critically discussed.

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Single-particle spectroscopy for functional nanomaterials

Cited by 204 publications

References 125 publications

Absolute quantum yield measurements of fluorescent proteins using a plasmonic nanocavity

Absolute quantum yield measurements of fluorescent proteins using a plasmonic nanocavity

Upconverted excitation energy lock-in for deep-ultraviolet enhancement

Carbon Nanomaterials Applied for the Treatment of Inflammatory Diseases: Preclinical Evidence

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