“…4,10,11 Another strategy is single-or double-pass CO 2 laser resurfacing, which has been reported to result in more rapid reepithelialization, fewer and less severe adverse effects, and good prospects of success. [12][13][14][15][16] The postoperative adverse effects of ablative wrinkle treatment are not the only important consideration in regard to patient satisfaction; preventing intraoperative pain is also a major factor. In our experience, treatment with systemic analgesics, anesthesia with topical lidocaine-prilocaine cream, infiltration anesthesia, nerve blocks, and tumescent anesthesia has been effective.…”