Single Photon Emission Computed Tomography with Technetium-99m Hexamethyl Propylenamino Oxime in the Pain-Free Interval of Migraine and Cluster Headache

Schlake, Hans-Peter; Böttger, I.; Grotemeyer, Karl-Heinz; Husstedt, IW; Vollet, B.; Schober, Otmar; Brune, G. G.

doi:10.1159/000117334

Cited by 22 publications

(15 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Such findings, which may reflect diffuse axonal injury and inflammation, are also consistent with several other studies of headache and pain syndromes [47], [48], [49]. An early study reported decreased cerebral blood flow is associated with common migraines suggesting that migraine attacks occur in connection with exacerbations of preexisting changes of neuronal activities, cerebral perfusion and metabolism [50]. In addition, in our study, low CBF in the left frontal lobe and right temporal lobe correlated with poorer reported physical health.…”

Section: Discussionsupporting

confidence: 89%

Clinical Comparison of 99mTc Exametazime and 123I Ioflupane SPECT in Patients with Chronic Mild Traumatic Brain Injury

et al. 2014

View full text Add to dashboard Cite

BackgroundThis study evaluated the clinical interpretations of single photon emission computed tomography (SPECT) using a cerebral blood flow and a dopamine transporter tracer in patients with chronic mild traumatic brain injury (TBI). The goal was to determine how these two different scan might be used and compared to each other in this patient population.Methods and FindingsTwenty-five patients with persistent symptoms after a mild TBI underwent SPECT with both 99mTc exametazime to measure cerebral blood flow (CBF) and 123I ioflupane to measure dopamine transporter (DAT) binding. The scans were interpreted by two expert readers blinded to any case information and were assessed for abnormal findings in comparison to 10 controls for each type of scan. Qualitative CBF scores for each cortical and subcortical region along with DAT binding scores for the striatum were compared to each other across subjects and to controls. In addition, symptoms were compared to brain scan findings. TBI patients had an average of 6 brain regions with abnormal perfusion compared to controls who had an average of 2 abnormal regions (p<0.001). Patient with headaches had lower CBF in the right frontal lobe, and higher CBF in the left parietal lobe compared to patients without headaches. Lower CBF in the right temporal lobe correlated with poorer reported physical health. Higher DAT binding was associated with more depressive symptoms and overall poorer reported mental health. There was no clear association between CBF and DAT binding in these patients.ConclusionsOverall, both scans detected abnormalities in brain function, but appear to reflect different types of physiological processes associated with chronic mild TBI symptoms. Both types of scans might have distinct uses in the evaluation of chronic TBI patients depending on the clinical scenario.

show abstract

Section: Discussionsupporting

confidence: 89%

Clinical Comparison of 99mTc Exametazime and 123I Ioflupane SPECT in Patients with Chronic Mild Traumatic Brain Injury

et al. 2014

View full text Add to dashboard Cite

show abstract

“…It was suggested that this may be because an equivalent regional analysis was not performed in this study. A number of other studies also have reported interictal abnormalities [32][33][34].…”

Section: Interictal Changesmentioning

confidence: 85%

Neuroimaging of migraine

Afridi

Goadsby²

2006

Current Science Inc

View full text Add to dashboard Cite

show abstract

“…Fundamental to the concept of idiopathic or primary headache, including migraine, tension-type headache, and [46] 1978 CH Xenon 133 9 ↑ Schlake et al [47] 1990 CH Tc 99m HM-PAO 5…”

Section: Morphometric Studies: Pointing Toward a Lesionmentioning

confidence: 99%

Hypothalamic involvement and activation in cluster headache

May

Goadsby

2001

Current Science Inc

View full text Add to dashboard Cite

Cluster headache is an episodic form of primary neurovascular headache that is both severe and relatively rare. It is characterized by episodes of headache with cranial parasympathetic activation and sympathetic impairment that come in bouts, or clusters. Its pathophysiology can be divided into understanding the attack phenotype and the biotype of the periodicity. Acute attacks of cluster headache are marked by trigeminal nerve-mediated pain and with cranial autonomic activation, trigeminal-autonomic cephalalgia; an activation that characterizes the phenotype of a group of headaches. The signature feature of cluster headache is its periodicity, the daily cycle of attacks when the patient is in an active bout, or the circumannual, or other period, cycling that distinguishes the on period from the off period. Functional brain imaging with positron emission tomography and structural imaging with voxel-based morphometry have identified an area in the posterior hypothalamic gray as key in understanding cluster headache. This area is subtly enlarged in its gray matter volume, active during an acute cluster headache but inactive when patients are challenged between bouts. Cluster headache is likely to be a form of primary neurovascular pain whose phenotypic expression relies on the trigeminal-autonomic reflex, with a biotype determined by the brain area, the posterior hypothalamus, in which the lesion seems to be located. Understanding both the phenotypic expression and the biotype will, respectively, enable better acute attack treatments and better preventative management of this horrible form of headache.

show abstract

Single Photon Emission Computed Tomography with Technetium-99m Hexamethyl Propylenamino Oxime in the Pain-Free Interval of Migraine and Cluster Headache

Cited by 22 publications

References 0 publications

Clinical Comparison of 99mTc Exametazime and 123I Ioflupane SPECT in Patients with Chronic Mild Traumatic Brain Injury

Clinical Comparison of 99mTc Exametazime and 123I Ioflupane SPECT in Patients with Chronic Mild Traumatic Brain Injury

Neuroimaging of migraine

Hypothalamic involvement and activation in cluster headache

Contact Info

Product

Resources

About