Single-photon emission computed tomography quantitation of gallium citrate uptake for the differentiation of lymphoma from benign hilar uptake.

Abstract

Lymphoma and benign hilar uptake differ significantly in their concentration of Ga 67. The present study shows that quantitative Ga-67 SPECT reliably differentiates lymphoma and benign uptake.

Positron Emission Tomography with 18-Fluorodeoxyglucose in the Staging and Follow-up of Lymphoma in the Chest

“…The reason for this phenomenon is presently unknown. In 59 out of 107 studies evaluated by Even-Sapir et al (15), the hilar uptake was not associated with lymphoma.…”

“…The current role of Ga-67 scintigraphy as part of staging work-up remains controversial, because sensitivity is decreased especially in the abdomen owing to hepatic uptake and excretion into the bowel (9)(10)(11). The specificity of Ga-67 scintigraphy is also limited because of uptake by normal tissue, especially in the pulmonary hila (5,(12)(13)(14)(15). The reason for false-positive uptake, in these studies called benign Ga-67 uptake, is presently unknown but it poses a diagnostic dilemma, especially in the monitoring of treatment results.…”

“…In 15 out of 23 lymphoma patients evaluated by Chapman et al (13) the hilar uptake was not associated with active lymphoma. Even-Sapir et al (15) correlated the uptake of Ga-67 in the hilar of lymphoma patients with computed tomography (CT) and follow-up examinations. In 59 of 107 thoracic single photon emission computed tomography (SPECT) studies Ga-67 uptake was detected in the hilar and mediastinal regions.…”

Where are we with nuclear medicine in pediatrics?

“…Nine-year-old girl with recurrent metastatic stage IV neuroblastoma. I23I-MIBG scan shows abnormal accumulation in the skull, thorax, abdomen, pelvis, shoulders, and lower limbs rebound will be positive on gallium scintigraphy with a characteristic bilobed triangular uptake and negative or near negative on thallium scintigraphy [17,[85][86][87][88].…”

Clinical pretreatment risk factors and prediction of outcome using gallium 67 scintigraphy in patients with Hodgkin's lymphoma

“…The gallium scan was considered positive for the presence of disease when abnormal focal or diffuse uptake of 67 Ga was observed in a localization incompatible with normal structures and unexplained by other causes. Diffuse lung uptake (19) and bilateral perihilar uptake (20) were not considered to indicate the presence of lymphoma.…”