1999
DOI: 10.1016/s0165-0327(98)00209-2
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Single photon emission tomography with 99m Tc-HMPAO in Arab patients with depression

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Cited by 26 publications
(7 citation statements)
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“…Imaging studies have also demonstrated that MDD may involve dysregulation of cortical activity, with lower activity in the left DPLFC and higher activity in the right DPLFC. 58,59 Further, rTMS treatment in MDD has often been shown to be associated with a normalization of hypoexcitability over the left prefrontal cortex and normalization of hyperexcitability over the right hemisphere, 36 consistent with the finding that rTMS applied at high frequencies increases excitability in the cortex, 60 while rTMS applied at low frequencies decreases excitability in the cortex. 17 Finally, studies have demonstrated that when 10 Hz rTMS is applied to the right DLPFC (that is, tantamount to increasing excitability in right DLPFC) dysphoric symptoms emerge.…”
Section: Additional Therapeutic Considerations: Mechanisms Of Rtms-inmentioning
confidence: 56%
“…Imaging studies have also demonstrated that MDD may involve dysregulation of cortical activity, with lower activity in the left DPLFC and higher activity in the right DPLFC. 58,59 Further, rTMS treatment in MDD has often been shown to be associated with a normalization of hypoexcitability over the left prefrontal cortex and normalization of hyperexcitability over the right hemisphere, 36 consistent with the finding that rTMS applied at high frequencies increases excitability in the cortex, 60 while rTMS applied at low frequencies decreases excitability in the cortex. 17 Finally, studies have demonstrated that when 10 Hz rTMS is applied to the right DLPFC (that is, tantamount to increasing excitability in right DLPFC) dysphoric symptoms emerge.…”
Section: Additional Therapeutic Considerations: Mechanisms Of Rtms-inmentioning
confidence: 56%
“…injection of 99m Tc‐HMPAO (hexamethyl propylene amine oxime). The details of data acquisition, processing and analysis are included in a companion publication (21).…”
Section: Methodsmentioning
confidence: 99%
“…These abnormalities have also been detected using other functional neuroimaging techniques (e.g., PET and SPECT) to measure CBF, brain metabolism, and neurochemical mechanisms, indicating changes in frontal, temporal, cingulate, thalamic, and cerebellar regions in patients with schizophrenia [10]. Abou-Saleh et al [11], in a SPECT study of Arab patients with schizophrenia, reported greater right CBF than normal controls in all cerebral regions except in the right and left anterior frontal regions. Patients showed a reversed left-toright laterality in the anterior frontal regions only.…”
Section: Studies In Schizophreniamentioning
confidence: 99%