Single point exposure LPBF for the production of biodegradable Zn-alloy lattice structures

Guaglione, Fabio; Caprio, Leonardo; Previtali, Barbara; Demir, Ali Gökhan

doi:10.1016/j.addma.2021.102426

Cited by 19 publications

(9 citation statements)

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“…Bone implants should have a through-hole structure similar to natural bone, so as to provide a necessary microenvironment for cell growth, angiogenesis, and new bone growth after implantation [ 19 , 20 ]. It is generally believed that the pore size suitable for bone tissue growth ranges from 200 to 600 μm.…”

Section: Discussionmentioning

confidence: 99%

Microstructure and Corrosion Behavior of Iron Based Biocomposites Prepared by Laser Additive Manufacturing

Zhou

Shuai

et al. 2022

Micromachines

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Iron (Fe) has attracted great attention as bone repair material owing to its favorable biocompatibility and mechanical properties. However, it degrades too slowly since the corrosion product layer prohibits the contact between the Fe matrix and body fluid. In this work, zinc sulfide (ZnS) was introduced into Fe bone implant manufactured using laser additive manufacturing technique. The incorporated ZnS underwent a disproportionation reaction and formed S-containing species, which was able to change the film properties including the semiconductivity, doping concentration, and film dissolution. As a result, it promoted the collapse of the passive film and accelerated the degradation rate of Fe matrix. Immersion tests proved that the Fe matrix experienced severe pitting corrosion with heavy corrosion product. Besides, the in vitro cell testing showed that Fe/ZnS possessed acceptable cell viabilities. This work indicated that Fe/ZnS biocomposite acted as a promising candidate for bone repair material.

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Section: Discussionmentioning

confidence: 99%

Microstructure and Corrosion Behavior of Iron Based Biocomposites Prepared by Laser Additive Manufacturing

Zhou

Shuai

et al. 2022

Micromachines

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“…However, these cutting-edge techniques offered better control over scaffolds’ porosity and pore size. But, evaporation was a concern during Zn processing by SLM (Yang et al , 2018) due to the low melting and boiling point of Zn material (Guaglione et al , 2021). Additionally, the initial investment in 3D printing tools and equipment was expensive, driving up the cost of fabricating scaffolds (Zhou et al , 2022).…”

Section: Introductionmentioning

confidence: 99%

Mapping the structural properties of zinc scaffold fabricated via rapid tooling for bone tissue engineering applications

Kansal

Dvivedi

Kumar

2023

RPJ

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Purpose The purpose of this study to investigate the organized porous network zinc (OPNZ) scaffolds. Their mechanical characteristics, surface roughness and fracture mechanism were assessed in relation to their structural properties. The prospects of fused deposition modeling (FDM) for printing metal scaffolds via rapid tooling have also been studied. Design/methodology/approach Zn scaffolds with different pore and strut sizes were manufactured via the rapid tooling method. This method is a multistep process that begins with the 3D printing of a polymer template. Later, a paraffin template was obtained from the prepared polymer template. Finally, this paraffin template was used to fabricate the Zn scaffold using microwave sintering. The characterization of prepared Zn samples involved structural characterization, microstructural study, surface roughness testing and compression testing. Moreover, based on the Gibson–Ashby model analysis, the model equations’ constant values were evaluated, which can help in predicting the mechanical properties of Zn scaffolds. Findings The scanning electron microscopy study confirmed that the fabricated sample pores were open and interconnected. The X-ray diffraction analysis revealed that the Zn scaffold contained hexagonal closed-packed Zn peaks related to the a-Zn phase, validating that scaffolds were free from contamination and impurity. The range for ultimate compressive strength, compressive modulus and plateau stresses for Zn samples were found to be 6.75–39 MPa, 0.14–3.51 GPa and 1.85–12.6 MPa by adjusting their porosity, which are comparable with the cancellous bones. The average roughness value for the Zn scaffolds was found to be 1.86 µm. Originality/value This research work can widen the scope for extrusion-based FDM printers for fabricating biocompatible and biodegradable metal Zn scaffolds. This study also revealed the effects of scaffold structural properties like porosity, pore and strut size effect on their mechanical characteristics in view of tissue engineering applications.

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“…So far, laser powder bed fusion (LPBF) has emerged as a widely adopted method for fabricating metallic components, including biodegradable metals [21,22]. The micro-architected structure of biodegradable Zn or Mg scaffolds could be precisely controlled through LPBF [23]. While previous studies have emphasized the importance of customized geometry, it is noteworthy that optimal degradation rates for bone scaffolds may vary depending on specific bone defect scenarios [4,[24][25][26].…”

Section: Introductionmentioning

confidence: 99%

The effect of topological design on the degradation behavior of additively manufactured porous zinc alloy

Li,

Shi,

et al. 2023

Preprint

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The advent of additively manufactured biodegradable porous metals presents a transformative opportunity to meet the criteria of ideal bone substitutes. Precisely tailoring their degradation behavior constitutes a pivotal aspect of this endeavor. In this study, for the first time, we investigated the effects of topological designs on the degradation profile of laser powder bed fusion (LPBF) Zn scaffolds under dynamic in vitro immersion tests. Specifically, four types of Zn-0.4Mn-0.2Mg scaffolds (beam-based: diamond, face center cubic; surface-based: gyroid, schwarz-P) were designed and fabricated. The degradation mechanism of the scaffolds was comprehensively evaluated using both experimental and simulation methods. The results illuminate the profound impact of structural design on the degradation properties of the Zn alloy scaffolds. The beam-based diamond and face center cubic scaffolds exhibited a degradation rate of 0.5–0.8 mm/year with a relatively uniform degradation mode under dynamic immersion. On the contrary, the surface-based gyroid and Schwarz-P scaffolds demonstrated a notably reduced degradation rate due to lower permeability. This restricted the diffusion of medium ions within the pores, culminating in the accumulation of degradation products and more severe localized degradation. This study underscores the potential of topological design as a compelling strategy for tailoring the degradation profile of additively manufactured biodegradable scaffolds, thereby advancing their suitability as bone substitutes.

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Single point exposure LPBF for the production of biodegradable Zn-alloy lattice structures

Cited by 19 publications

References 50 publications

Microstructure and Corrosion Behavior of Iron Based Biocomposites Prepared by Laser Additive Manufacturing

Microstructure and Corrosion Behavior of Iron Based Biocomposites Prepared by Laser Additive Manufacturing

Mapping the structural properties of zinc scaffold fabricated via rapid tooling for bone tissue engineering applications

The effect of topological design on the degradation behavior of additively manufactured porous zinc alloy

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