Single port robot-assisted radical and simple prostatectomy: a systematic review and meta-analysis

Franco, Antonio; Ditonno, Francesco; Manfredi, Celeste; Pellegrino, Antony A.; Licari, Leslie Claire; Bologna, Eugenio; Feng, Carol; Antonelli, Alessandro; De Sio, Marco; De Nunzio, Cosimo; Porpiglia, Francesco; Cherullo, Edward E.; Kaouk, Jihad; Crivellaro, Simone; Autorino, Riccardo

doi:10.1038/s41391-024-00787-2

Cited by 15 publications

(2 citation statements)

References 69 publications

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“…Moreover, while salvage RARP is feasible, albeit technically challenging, after recurrence after primary treatment, including ADT, no data regarding patients with low or favorable intermediate risk who then underwent these subsequent treatments are available to assess the impact of ADT on PCa progression [ 22 , 23 , 24 , 25 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

Prognostic Impact and Clinical Implications of Adverse Tumor Grade in Very Favorable Low- and Intermediate-Risk Prostate Cancer Patients Treated with Robot-Assisted Radical Prostatectomy: Experience of a Single Tertiary Referral Center

Porcaro,

Bianchi,

Gallina

et al. 2024

Cancers

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Objectives: To assess the prognostic impact and predictors of adverse tumor grade in very favorable low- and intermediate-risk prostate cancer (PCa) patients treated with robot-assisted radical prostatectomy (RARP). Methods: Data of low- and intermediate PCa risk-class patients were retrieved from a prospectively maintained institutional database. Adverse tumor grade was defined as pathology ISUP grade group > 2. Disease progression was defined as a biochemical recurrence event and/or local recurrence and/or distant metastases. Associations were assessed by Cox’s proportional hazards and logistic regression model. Results: Between January 2013 and October 2020, the study evaluated a population of 289 patients, including 178 low-risk cases (61.1%) and 111 intermediate-risk subjects (38.4%); unfavorable tumor grade was detected in 82 cases (28.4%). PCa progression, which occurred in 29 patients (10%), was independently predicted by adverse tumor grade and biopsy ISUP grade group 2, with the former showing stronger associations (hazard ratio, HR = 4.478; 95% CI: 1.840–10.895; p = 0.001) than the latter (HR = 2.336; 95% CI: 1.057–5.164; p = 0.036). Older age and biopsy ISUP grade group 2 were independent clinical predictors of adverse tumor grade, associated with larger tumors that eventually presented non-organ-confined disease. Conclusions: In a very favorable PCa patient population, adverse tumor grade was an unfavorable prognostic factor for disease progression. Active surveillance in very favorable intermediate-risk patients is still a hazard, so molecular and genetic testing of biopsy specimens is needed.

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Section: Discussionmentioning

confidence: 99%

Prognostic Impact and Clinical Implications of Adverse Tumor Grade in Very Favorable Low- and Intermediate-Risk Prostate Cancer Patients Treated with Robot-Assisted Radical Prostatectomy: Experience of a Single Tertiary Referral Center

Porcaro,

Bianchi,

Gallina

et al. 2024

Cancers

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“…In alignment with the focus of our systematic review on integrating immersive technologies within STEM education, we adopt the PICOS approach-a widely recognized research framework for formulating precise and focused research inquiries for systematic reviews (Amir-Behghadami and Janati, 2020; Deng et al, 2024;Franco et al, 2024). In particular, we follow the inclusion and eligibility criteria exposed by Amir-Behghadami and Janati (2020).…”

Section: Methodsmentioning

confidence: 99%

Integrating immersive technologies with STEM education: a systematic review

Tene,

Marcatoma Tixi,

Palacios Robalino

et al. 2024

Front. Educ.

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ObjectiveThis systematic review aims to synthesize current knowledge on integrating immersive technologies, namely Virtual Reality (VR) and Augmented Reality (AR), in Science, Technology, Engineering, Mathematics (STEM) education, and to lighten their impact on student performance and engagement.MethodsAdhering to PRISMA guidelines, a detailed search strategy across Scopus and Web of Science databases identified relevant peer-reviewed journal articles published from 2002 to 2023. The PICOS approach informed our inclusion criteria, focusing on empirical studies that assessed the application of VR and AR technologies in Science, Technology, Engineering, Mathematics (STEM) educational settings. Studies were evaluated for methodological quality, and data extraction was meticulous, with variables categorized as engagement, performance, or a combination of both.AnalysisA descriptive and statistical analysis using chi-square tests was employed to examine the relationship between the type of technology (AR, VR, XR, MR) and the educational outcomes. This quantitative assessment provided a nuanced understanding of the interplay between various immersive technologies and their pedagogical effectiveness.ResultsOut of 143 initially identified articles, 22 met the inclusion criteria for detailed analysis. Findings revealed that AR was the most studied technology, followed by VR. Most studies reported positive effects on student engagement and performance, with increased effectiveness being less frequently observed. A notable portion of the studies specifically investigated the combination of performance and engagement, underscoring the multifaceted benefits of immersive technologies in education.ConclusionsImmersive technologies are reshaping STEM education by enhancing engagement and performance. Integrating VR and AR offers promising educational benefits, including improved comprehension of complex concepts, increased student motivation, and enriched collaborative learning experiences. However, the field requires a globally inclusive and adaptable framework for rapid technological evolution and diverse educational contexts. Future research should broaden its scope to include multilingual literature and non-traditional academic channels, ensure ethical standards are upheld, and focus on personalization and adaptability to maximize the educational potential of these technologies.

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Comparing post-treatment urinary and colorectal procedures in prostate cancer patients using population-based linked data

Tiruye,

Jay,

Higgs

et al. 2024

Int Urol Nephrol

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Single port robot-assisted radical and simple prostatectomy: a systematic review and meta-analysis

Cited by 15 publications

References 69 publications

Prognostic Impact and Clinical Implications of Adverse Tumor Grade in Very Favorable Low- and Intermediate-Risk Prostate Cancer Patients Treated with Robot-Assisted Radical Prostatectomy: Experience of a Single Tertiary Referral Center

Prognostic Impact and Clinical Implications of Adverse Tumor Grade in Very Favorable Low- and Intermediate-Risk Prostate Cancer Patients Treated with Robot-Assisted Radical Prostatectomy: Experience of a Single Tertiary Referral Center

Integrating immersive technologies with STEM education: a systematic review

Comparing post-treatment urinary and colorectal procedures in prostate cancer patients using population-based linked data

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