Single Potential Analysis of
Cavernous Electrical Activity

Truß, Michael C.; Djamilian, Mohamad H.; Tan, Hong-Kie; Hinrichs, H.; Feistner, Helmut; Stief, Christian G.; Jonas, Udo

doi:10.1159/000474329

Cited by 29 publications

(12 citation statements)

References 9 publications

(18 reference statements)

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“…This finding is in accordance with previous research 6 in which these signals were interpreted as asynchronous activity of the smooth muscle cells as a consequence of sympathetic tone reduction during tumescence. However, as relaxation of cavernous smooth muscle is attributed not only to a reduction of sympathetic activity but also to an increase in parasympathetic activity, [13][14][15] it appears possible that CC activity during tumescence mirrors parasympathetic input to CC.…”

Section: Figuresupporting

confidence: 93%

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Brain potentials related to corpus cavernosum electromyography

Ponseti

Bosinski

2010

Int J Impot Res

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The aim of this study was to elucidate the relation between electrical activity in the corpus cavernosum (CC), penile responses and brain processes. EEG potentials, penile circumference and electrical activity of the CC (CC-EMG) were recorded simultaneously while male subjects were exposed to visual sexual stimuli. The trials were sorted by the penile response of the subjects (erection, maintenance or detumescence). The corresponding EEG recordings were subjected to independent component analysis (ICA) and then correlated with CC activity. We found that CC activity was decreased in the case of erection. EEG activity was found to be correlated with CC activity in most cases at the same instant or with subsequent CC activity. EEG activity at early time points after stimulus onset (o300 ms) was found to be correlated with CC activity, indicating penile response preparation at a pre-attentive processing level. These data indicate that (i) CC activity is under the control of brain processing and (ii) autonomous input reaches the CC in fractions of a second after sexual stimulus onset. Our experimental paradigm should be used for the study of psychogenic erectile dysfunctions and could help in the development of an objective measurement of this disturbance

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Section: Figuresupporting

confidence: 93%

“…[2][3][4][5] Detailed analysis of CC potentials during erection induced by audiovisual sexual stimulation showed a decrease in amplitude and duration, with an increase in frequency. 6 This was interpreted as desynchronization of the smooth muscle cells following reduction of the sympathetic tone.…”

Section: Introductionmentioning

confidence: 99%

Brain potentials related to corpus cavernosum electromyography

Ponseti

Bosinski

2010

Int J Impot Res

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“…their results [3][4][5]9]. The previous and present investigations show that the essential characteristics of the Simultaneous recordings of SCA and SSRs (elec-inhibited by tumescence and full erection of the penis [1,3,10]; (iii) these activities can be recorded by CN [3,4] and BN [1] electrodes, with surface recording also able to record SCA [11,12]. The amplitude of the oscillations or the potentials in a burst of SCA did not diCer significantly with the three recording techniques, although amplitudes were slightly higher on surface recording.…”

Section: Methodsmentioning

confidence: 93%

“…These recorded potentials were termed 'single potential analysis of all included in the individual evaluation of somatic and autonomic neuropathy. The local university hospital cavernosal electrical activity' (SPACE) [3][4][5], and the phenomenon received much attention in the urological ethical committee approved the investigation. The recording of cavernosal activity was basically literature.…”

mentioning

confidence: 99%

“…The recording of cavernosal activity was basically literature. To date, neurologists and clinical neurophysiologists have remained unconvinced of the utility of SPACE as described by Stief et al [3,4]. Briefly, two CN electrodes (Medelec disposable needle electrode DMC-37, or spontaneous cavernosal activity (SCA), because these potentials may partly originate from artefacts.…”

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confidence: 99%

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The nature of spontaneous cavernosal activity

1999

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Objective To determine the characteristics of spontaneous cavernosal activity (SCA) and to relate this to previous descriptions of spontaneous potentials from the cavernosum (single potential analysis of cavernosal activity, SPACE). Subjects and methods The SCA was recorded in 31 normal men with no sexual problems; various manipulations were applied using concentric‐needle (CN), bipolar needle (BN) and surface electrodes. The electrical activity was compared with the observed slow retractile movements of the flaccid penis and with other assessments of electrical activity from skin. Results SCA appeared synchronously from both sides of the cavernosal bodies in all normal subjects when detected by CN electrodes. The synchronous recordings both by CN and BN electrodes, or both by CN and surface electrodes registered similar oscillatory potentials. Slow retractile movements of the penis occurred synchronously with these potentials in all subjects and both were absent during erection. Conclusion SCA is apparently related to biomechanical slow movement artefacts of the flaccid penis; it may be a consequence of the summed contractions of smooth muscle groups in the cavernosum. Observing the small retractile slow movements of the flaccid penis and recording the SCA may be a useful indirect method to characterize cavernosal neural innervation and smooth muscle activity.

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Resultats preliminaires d’injections intracaverneuses d’un donneur d’oxyde d’azote (NO), la linsidomine, dans le traitement de l’impuissance

Stief¹,

Holmquist

Andersson

1991

Androl.

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PRELIMINARY RESULTS WITH THE NITRIC OXYDE (NO) DONOR SIN 1 IN THE TREATMENT OF HUMAN EREC-TILE DYSFUNCTION.Recent experimental studies showed an important role of endothelium derived relaxing factor (EDRF) for cavernous smooth muscle relaxation. Since nitric oxide (NO) seems to account for the biological actions of EDRF, a study was done to examine a possible role of the NO-donor SIN-I in the treatment of erectile dysfunction. To determine the therapeutic range, 0.1, 0.2, 0.5 and 1 mg SIN-I were injected intracavernously in 2 patients with erectile dysfunction each. Then, 40 patients were injected 1 mg SIN-1 including 4 patients that had prolonged erections to minimal doses of papaverine-phentolamine and 4 patients that did not respond with a full erection to other pharmacologic agents, lntracavernous injection of SIN-1 induced a dose dependent erectile response by increasing the arterial inflow and relaxing cavernous smooth muscles. To I mg SIN-I, 19 patients had a full, 14 an ahnost full and 7 a moderate erection. There were no systemic or local side effects. In the patients with prolonged erections to papaverine-phentolamine, the mean duration of a full erection to SIN-1 was 68 minutes. Compared to a papaverine (15 mg/ml)-phentolamine (0.5 mg/ml) mixture, the erectile response to SIN-I was superior in 8, comparable in 29 and inferior in 3 patients. Our preliminary data suggest a possible role of SIN-I for the treatment of erectile dysfunction. The absence of prolonged erections by its spontaneous intracavernous decomposition, a maximal smooth muscle relaxation by a receptor independant action and its low cost indicate its potential to become a standard drug for intracavernous pharmacotherapy. Key-words : erectile dysfunction, autoqnjection therapy, EDRF, nitric oxyde Linsidomine. Andrologie, 1991, 1 : 83-84.Le muscle lisse caverneux silud duns la parol des art~res et des espaces sinusoides joue un rdle capital duns rdrection. Sa relaxation diminue les rdsistances pdriphdriques, permet le remplissage des sinus cavemeux e~ rdduit le drainage veineux (L13). Le factcur relaxant d'origine endothdliale (EDRF) joue un r61e physiologique important dans la relaxation des muscles lisses vasculaires. On pense gdndralement que c'est le monoxyde d'azote (NO) ou un compos6 contenant du NO et synthdtisd 5, partir de la L-Arginine, qui rend compte de ractivit6 biologique de rEDRF (3,5,6,10). Rdcemment des 6tudes in vitro fakes sur le pdnis du lapin et de rhomme (7,8,10,12) ont montrd que le NO, ou un composd en contenant et probablement libdrd par des nerfs, jouent un rdle dans la rdgulation du tonus du muscle lisse caverneux. In vivo, des dtudes faites chez le lapin sont dgalement en faveur d'un rdle de la vole L-Arginine-NO dans le contrdle de rdrection (9).I1 paraissait donc intdressant de tester rinjection intracaverneuse d'un donneur de NO dans le traitement de rimpuissance. Ce type d'injection devrait induire un effet plus proche de la physiologie que les injections de Papavdrine ou de Prostaglandine El. Nous prdsentons...

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Single Potential Analysis of Cavernous Electrical Activity

Cited by 29 publications

References 9 publications

Brain potentials related to corpus cavernosum electromyography

Brain potentials related to corpus cavernosum electromyography

The nature of spontaneous cavernosal activity

Resultats preliminaires d’injections intracaverneuses d’un donneur d’oxyde d’azote (NO), la linsidomine, dans le traitement de l’impuissance

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