Single Production of Kojic Acid by Aspergillus flavus and the Revision of Flufuran

Ola, Antonius R. B.; Metboki, Gema; Lay, Caterina S; Sugi, Yoseph; Rozari, Philiphi de; Darmakusuma, Dodi; Hakim, Euis H.

doi:10.3390/molecules24224200

Cited by 30 publications

(14 citation statements)

References 19 publications

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“…This observation was not detected in pure liquid or agar cultures of A. flavus , which indicates that the detected secretion was inducible upon biotic stress/competition. kojic acid and aspergillic acids are among the major secretions of A. flavus in growing culture media [ 79 , 80 ]. Both acids are known to possess antifungal and antibacterial activity, which may be responsible for mycelial decay [ 78 , 81 , 82 ].…”

Section: Discussionmentioning

confidence: 99%

Polyphasic Characterization of Four Aspergillus Species as Potential Biocontrol Agents for White Mold Disease of Bean

Atallah

Mazrou

Atia

et al. 2022

JoF

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The genus Aspergillus comprises several species that play pivotal roles in agriculture. Herein, we morphologically and physiologically characterized four genetically distinct Aspergillus spp., namely A. japonicus, A. niger, A. flavus, and A. pseudoelegans, and examined their ability to suppress the white mold disease of bean caused by Sclerotinia sclerotiorum in vitro and under greenhouse conditions. Seriation type of Aspergillus spp. correlates with conidiospores discharge as detected on the Petri glass lid. Members of Nigri section cover their conidial heads with hard shells after prolonged incubation. In addition, sporulation of the tested Aspergillus isolates is temperature sensitive as it becomes inhibited at low temperatures and the colonies become white. Examined Aspergillus spp. were neither infectious to legumes nor aflatoxigenic as confirmed by HPLC except for A. flavus and A. pseudoelegans which, secreted 5 and 1 ppm of aflatoxin B1, respectively. Co-inoculations of Sclerotinia’s mycelium or sclerotia with a spore suspension of Aspergillus spp. inhibited their germination on PDA at 18 °C and 28 °C, and halted disease onset on detached common bean and soybean leaves. Similarly, plants treated with A. japonicus and A. niger showed the highest survival rates compared to untreated plants. In conclusion, black Aspergillus spp. are efficient biocides and safe alternatives for the management of plant diseases, particularly in organic farms.

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Section: Discussionmentioning

confidence: 99%

Polyphasic Characterization of Four Aspergillus Species as Potential Biocontrol Agents for White Mold Disease of Bean

Atallah

Mazrou

Atia

et al. 2022

JoF

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“…Kojic acid (KA) (5‐hydroxy‐2‐hydroxymethyl‐4H‐pyran‐4‐one) is a secondary metabolite obtained from various fungal species; for example, aspergillus, [1] and penicillium [2] . KA exhibits a wide variety of pharmacological activities such as antitumor, [3] antidiabetic, [4] antimelanogenic, [5] human neutrophil elastase inhibitors, [6] antibacterial, [7] anti‐inflammatory, [8] and antioxidant [9] .…”

Section: Figurementioning

confidence: 99%

Structure‐Activity Relationship of Indolylkojylmethane Based on Antiproliferative Activity against Breast Cancer

Koli

Reena²,

Mehra

et al. 2020

ChemistrySelect

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A series of indolylkojylmethane (IKM) derivatives (1–23) was synthesized using a multicomponent one‐pot reaction under solvent‐free condition using a heterogeneous catalyst. The synthesized compounds were screened against breast cancer cell lines MDA‐MB‐231, MCF7, and T47D. The structure‐activity relationship revealed that IKM synthesized from aliphatic aldehydes (9–11) were active against all three cell lines and showed IC50 value of 0.15 μM–3.93 μM. IKM synthesized from aromatic aldehydes having electron‐donating group (1, 5, and 6) specifically inhibited the proliferation of the MDA‐MB‐231 cell line. The effect of various substituted indoles (12–17) was also studied and observed that compound 14 synthesized from 5‐cyanoindole, specifically inhibited T47D cell line proliferation. Replacing indole (1) with nucleophiles (18–23) in IKM decreased the antiproliferative activity. Compound 10 synthesized from kojic acid, indole and octanal was found to be most potent with IC50 values of 0.21, 0.15, and 3.45 μM against MDA‐MB‐231, MCF7, and T47D, respectively.

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“…Endophytic fungi have provided novel structure and important bioactive natural products and are constantly explored for their significant biological activity [1][2]. Various novel bioactive secondary metabolites having antibacterial, antiviral, cytotoxic, antifungal, and anticancer activities have been reported [3][4][5][6][7][8].…”

Section: ■ Introductionmentioning

confidence: 99%

Bioactive Secondary Metabolites from the Endophytic Fungi <i>Alternaria</i> sp.

Ola

Darmakusuma²,

Kadang³

et al. 2022

Indones. J. Chem.

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Shifting the drug discovery from plants to microorganisms due to minimizing the ecological effects has led to the increasing work on finding bioactive metabolites from endophytic fungi, especially those isolated from medicinal plants growing in arid and semi-arid land. An endophytic fungi Alternaria sp. isolated from dry land was cultivated on solid rice media and then extracted with ethyl acetate. From the fungal ethyl acetate crude extract of Alternaria sp., compounds altertoxin I (1) and II (2), and stemphyltoxin III (3), were isolated based on the bioactivity assay. The structures of compounds 1-3 were identified using UV, NMR, and mass spectral data and compared to those spectral data reported in the literature. The absolute configuration was determined to be the same as the previous report based on the comparison with the optical rotation value. The three compounds showed strong cytotoxic activity, with altertoxin II being the most active ones having the inhibition of growth observed at 94.4% against murine lymphoma L5178Y cell line at 10 µg/mL. The activity of altertoxin II (2) was probably contributed by the epoxytetralone moiety. The finding of this study still confirms the importance of endophytic fungi as sources of bioactive molecules.

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Single Production of Kojic Acid by Aspergillus flavus and the Revision of Flufuran

Cited by 30 publications

References 19 publications

Polyphasic Characterization of Four Aspergillus Species as Potential Biocontrol Agents for White Mold Disease of Bean

Polyphasic Characterization of Four Aspergillus Species as Potential Biocontrol Agents for White Mold Disease of Bean

Structure‐Activity Relationship of Indolylkojylmethane Based on Antiproliferative Activity against Breast Cancer

Bioactive Secondary Metabolites from the Endophytic Fungi <i>Alternaria</i> sp.

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