2023
DOI: 10.1088/1361-6560/acc9f8
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Single proton LET characterization with the Timepix detector and artificial intelligence for advanced proton therapy treatment planning

Abstract: Objective: Protons have advantageous dose distributions and are increasingly used in cancer therapy. At the depth of the Bragg peak range, protons produce a mixed radiation field consisting of low- and high-linear energy transfer (LET) components, the latter of which is characterized by an increased ionization density on the microscopic scale associated with increased biological effectiveness. Prediction of the yield and LET of primary and secondary charged particles at a certain depth in the patient is perfo… Show more

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Cited by 15 publications
(4 citation statements)
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“…Silicon-based Timepix3 detectors have been also used for measurements of LET based on energy deposition distributions of various proton energies. Discrepancies of 12% were found in the comparisons of measurements and MC simulations using TOPAS (Nabha et al 2022) and 17% between measurements and simulations using convolutional neural networks (Stasica et al 2023).…”
Section: Discussionmentioning
confidence: 99%
“…Silicon-based Timepix3 detectors have been also used for measurements of LET based on energy deposition distributions of various proton energies. Discrepancies of 12% were found in the comparisons of measurements and MC simulations using TOPAS (Nabha et al 2022) and 17% between measurements and simulations using convolutional neural networks (Stasica et al 2023).…”
Section: Discussionmentioning
confidence: 99%
“…The Timepix family of hybrid semiconductor pixelated detectors, including Timepix1 (TPX), Timepix3 (TPX3), and Timepix2 (TPX2), has proven to be a reliable tool for radiation spectrometry and particle tracking [1,2]. These detectors offer the unique advantage of precise energy measurements and time-stamping capabilities, making them highly adaptable to a wide range of scientific and industrial applications such as space radiation monitoring [3], particle radiotherapy [4,5], imaging with X-rays and particles [10,11], Compton camera, radiation tracking [7], dosimetry [9], neutron detection [4,6], etc. Despite their vast potential, the complex data generated by Timepix detectors necessitates the development of advanced data processing techniques to explore their full potential.…”
Section: Introduction and Detectorsmentioning
confidence: 99%
“…Nowadays, modern TPSs used in proton or heavy ion facilities are focus on a LET-based model that should be used in the final treatment optimization process to increase the spare of the healthy tissue (Liu et al 2013, Gu et al 2021. The LET of the particles that are crossing a pixeled detector is of interest for primary and secondary radiation spectral characterization especially when recent developments of TPS allow for LET treatment planning (Nabha et al 2022, McIntyre et al 2023, Novak et al 2023, Stasica et al 2023.…”
Section: Introductionmentioning
confidence: 99%