The damage effect and mechanism of laser irradiation on long-wave focal plane array (FPA) GaAs/AlGaAs quantum well infrared photodetector (QWIP) were preliminarily explored by using numerical simulation and experiment methods. Piecewise functions were employed to simulate the complex boundary structure of the QWIP, enabling the numerical simulation investigation of mono-pulse, nano-second, long-wave infrared laser irradiation damage effect on the QWIP. The highest QWIP temperature, the highest surface temperature and the maximum circumferential thermal stress were analyzed in relation to laser energy density. The pulse average energy density thresholds of thermal decomposition damage, melting damage and thermal stress-induced damage were theoretically obtained. Preliminary experiments were then conducted by using a mono-pulse, nano-second, 7.2 μm all-solid-state long-wave infrared laser. The experimental results revealed a point-shape damage in QWIP response measurement after the irradiation by a laser pulse of average energy density 1.30 J cm−2, due to the decomposition of GaAs. At a higher average energy density 5.42 J cm−2, both melting and stress-induced damages appeared, with the damage morphology predominantly influenced by stress-induced damage, resulting in the occurrence of blind pixels or the losing of pixels. Furthermore, at laser pulse average energy density 12.48 J cm−2, line-shape damage of the QWIP was observed.