In the U.S., approximately 47% of the total electricity use comes from residential buildings. Most of the residential buildings use HVAC system to ventilate, cool, or heat the indoor environmental spaces mechanically, rather than using natural outdoor air in transition seasons, even though the outdoor environmental conditions are favorable for indoor thermal comfort. In this case, an HVAC system using mixed-mode ventilation with an appropriate ratio of using indoor air and outdoor air could decrease the energy use in residential buildings. This research uses high-granular HVAC electricity use data with indoor thermostat data and outdoor weather data from residential buildings in Austin, Texas, to evaluate the benefits of energy and economics when using HVAC mixed-mode ventilation in spring and fall transition seasons. The results demonstrate that the household owners could save approximately 150.79 kWh of total HVAC energy use and 24.41% of HVAC cost in spring transition months (April/May), and similarly, 143.86 kWh of energy use and 27.2% cost savings in fall transition months (October/November). The results could support further study to use automatically operated windows for natural ventilation to reduce energy use in residential buildings toward sustainable development.