Single step fabrication of hollow microneedles and an experimental package for controlled drug delivery

Ghate, Vivek; Renjith, Anu; Badnikar, Kedar; Pahal, Suman; Jayadevi, Shreyas N.; Nayak, M. M.; Vemula, Praveen Kumar; Subramanyam, Dinesh Narasimhaiah

doi:10.1016/j.ijpharm.2022.122546

Cited by 14 publications

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Remote‐Controlled Sensing and Drug Delivery via 3D‐Printed Hollow Microneedles

Razzaghi,

Ninan,

Azimzadeh

et al. 2024

Adv Healthcare Materials

View full text Add to dashboard Cite

Remote health monitoring and treatment serve as critical drivers for advancing health equity, bridging geographical and socioeconomic disparities, ensuring equitable access to quality healthcare for those in underserved or remote regions. By democratizing healthcare, this approach offers timely interventions, continuous monitoring, and personalized care independent of one's location or socioeconomic status, thereby striving for an equitable distribution of health resources and outcomes. Meanwhile, microneedle arrays (MNAs), characterized by micron‐scaled needles, revolutionize painless and minimally invasive access to interstitial fluid for drug delivery and diagnostics. This paper introduces an integrated theranostic MNA system employing an array of colorimetric sensors to quantitatively measure interstitial fluid pH, glucose, and lactate, alongside a remotely‐triggered system enabling on‐demand drug delivery. Integration of an ultrasonic atomizer streamlines the MNA, facilitating rapid, pumpless, and point‐of‐care drug delivery, enhancing system portability while reducing complexities. An accompanying smartphone application interfaces the sensing and drug delivery components. Demonstrated capabilities include detecting pH (3 to 8), glucose (up to 16 mM), and lactate (up to 3.2 mM), showcasing on‐demand drug delivery, and assessing delivery system performance via a scratch assay. This innovative approach confronts drug delivery challenges, particularly in managing chronic diseases requiring long‐term treatment, while also offering avenues for non‐invasive health monitoring through microneedle‐based sensors.This article is protected by copyright. All rights reserved

show abstract