Single-step nano-engineering of multiple micro-rough metals via anodization

Chopra, Divya; Guo, Tianqi; Ivanovski, Sašo; Gulati, Karan

doi:10.1007/s12274-022-4847-8

Cited by 17 publications

(8 citation statements)

References 66 publications

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“…[7] The electrolyte was further conditioned (aged) by repeated anodization as described previously. [24,63] Anodization was performed using Ti wire (length immersed in electrolyte/anodized: 5 mm) as anode and a non-target Ti wire as cathode at 60 V for 10 min using a Keysight E36106A DC power supply to fabricate TiO 2 nanopores (TiO 2 -NP). [4] Ti wires (curved with micro-roughness) were used as model implants and were referred to as implants in the study.…”

Section: Methodsmentioning

confidence: 99%

“…Use of conditioned electrolyte (appropriately aged), single-step anodization, presence of underlying micro-grooves and reduced voltage/time resulted in the formation of anisotropic TiO 2 -NPs (average diameter 57 ± 4 nm). [7,24] NPs are like conventional TiO 2 nanotubes that are fused at the top with underlying nanotubular structures. Previously, dual micro-and nanoporous implants have been used to mechanically stimulate cells toward achieving superior soft-tissue and osseointegration.…”

Section: Surface Morphology and Roughnessmentioning

confidence: 99%

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Electrically Stimulated Dental Implants Triggers Soft‐Tissue Integration and Bactericidal Functions

Jayasree,

Cartmell,

Ivanovski

et al. 2024

Adv Funct Materials

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Modulating cellular functions at the dental implant‐tissue interface to augment integration and prevent bacterial ingress is crucial for achieving early stability and long‐term implant success. Nano‐engineering strategies, such as anodized titanium implants with titania (TiO2) nanotubes/nanopores, are emerging as a promising dental implant surface modification approach to enhance integration and prevent infection. Achieving on‐demand therapy through electrical stimulation therapy (EST, supply of voltage/current to local tissue) may be advantageous but has not been explored for dental implants. Further, anodized implants with TiO2 nanotubes/nanopores represent a semi‐conducting modification that can impede EST effectiveness. In this pioneering study, TiO2 nanopores are converted into conducting Ti nanopores to perform EST to achieve superior soft‐tissue integration and antibacterial efficacy. In‐depth surface characterizations are followed by assays investigating the effect of EST on cultured human salivary biofilm and gingival fibroblasts. Significant bactericidal efficacy is demonstrated for EST (1.5 V for 5 min per day) using Ti nanopores. Further, EST enhanced fibroblast proliferation and collagen secretion. In summary, EST applied to Ti nanoporous implants promotes soft‐tissue healing and antibacterial functions and is proposed as a next‐generation approach in implant dentistry to achieve on‐demand therapy.

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Section: Methodsmentioning

confidence: 99%

Section: Surface Morphology and Roughnessmentioning

confidence: 99%

Electrically Stimulated Dental Implants Triggers Soft‐Tissue Integration and Bactericidal Functions

Jayasree,

Cartmell,

Ivanovski

et al. 2024

Adv Funct Materials

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“…This technique is used to fabricate an oxide layer with various nanostructure configurations [ 245 ]. Briefly, anodization involves immersion of metal implant as anode and counter electrode (cathode) in an electrolyte containing water/fluoride and supply of appropriate voltage/current [ 246 , 247 ]. Under specific anodization conditions (water/fluoride content, voltage, current, time, etc.…”

Section: Nano-engineered Niti Alloymentioning

confidence: 99%

Advancing Nitinol: From heat treatment to surface functionalization for nickel–titanium (NiTi) instruments in endodontics

Chan

Gulati

Peters

2023

Bioactive Materials

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“…Briefly, EA involves the oxidization of target Ti within a DC-operated electrochemical cell by driving anode Ti to react with the oxygen from the electrolyte and form the TiO 2 barrier layer (BL) [ 81 , 82 ]. In the F-containing electrolytes, the oxidized TiO 2 BL then reacts with F - to form water-soluble [TiF 6 ] 2− , and finally, dissolve into the electrolyte to self-order hollow nanostructures, upon attainment of an anodization equilibrium [ 83 ]. Tailoring the electrolyte conditions and adjusting EA parameters (voltage, current, and time) could yield various nanostructures on Ti implants, including titania nanotubes (TNTs), titania nanopores (TNPs), and nanotemplates (NTs) [ 84 , 85 ].…”

Section: Electrochemically Anodized Ti Implantsmentioning

confidence: 99%

“…Tailoring the electrolyte conditions and adjusting EA parameters (voltage, current, and time) could yield various nanostructures on Ti implants, including titania nanotubes (TNTs), titania nanopores (TNPs), and nanotemplates (NTs) [ 84 , 85 ]. Additionally, it has been reported that the distribution of TNTs/TNPs was influenced by the microscale topography of the underlying substrate, and dual micro-nanostructures can be fabricated via conserved underlying substrate micro-topography [ 83 , 86 ]. The use of electrolyte aging (repeated use of the same electrolyte to anodize non-target Ti before anodizing target-Ti) conditions the electrolyte to enable the fabrication of dual micro-rough and nanoporous structures on micro-machined Ti implants [ 82 , 83 , 87 ].…”

Section: Electrochemically Anodized Ti Implantsmentioning

confidence: 99%

Enhanced Corrosion Resistance and Local Therapy from Nano-Engineered Titanium Dental Implants

et al. 2023

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Titanium is the ideal material for fabricating dental implants with favorable biocompatibility and biomechanics. However, the chemical corrosions arising from interaction with the surrounding tissues and fluids in oral cavity can challenge the integrity of Ti implants and leach Ti ions/nanoparticles, thereby causing cytotoxicity. Various nanoscale surface modifications have been performed to augment the chemical and electrochemical stability of Ti-based dental implants, and this review discusses and details these advances. For instance, depositing nanowires/nanoparticles via alkali-heat treatment and plasma spraying results in the fabrication of a nanostructured layer to reduce chemical corrosion. Further, refining the grain size to nanoscale could enhance Ti implants’ mechanical and chemical stability by alleviating the internal strain and establishing a uniform TiO2 layer. More recently, electrochemical anodization (EA) has emerged as a promising method to fabricate controlled TiO2 nanostructures on Ti dental implants. These anodized implants enhance Ti implants’ corrosion resistance and bioactivity. A particular focus of this review is to highlight critical advances in anodized Ti implants with nanotubes/nanopores for local drug delivery of potent therapeutics to augment osseo- and soft-tissue integration. This review aims to improve the understanding of novel nano-engineered Ti dental implant modifications, focusing on anodized nanostructures to fabricate the next generation of therapeutic and corrosion-resistant dental implants. The review explores the latest developments, clinical translation challenges, and future directions to assist in developing the next generation of dental implants that will survive long-term in the complex corrosive oral microenvironment.

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Single-step nano-engineering of multiple micro-rough metals via anodization

Cited by 17 publications

References 66 publications

Electrically Stimulated Dental Implants Triggers Soft‐Tissue Integration and Bactericidal Functions

Electrically Stimulated Dental Implants Triggers Soft‐Tissue Integration and Bactericidal Functions

Advancing Nitinol: From heat treatment to surface functionalization for nickel–titanium (NiTi) instruments in endodontics

Enhanced Corrosion Resistance and Local Therapy from Nano-Engineered Titanium Dental Implants

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