“…A variety of authors from diverse disciplines have spoken about the value of N-of-1 research (Guyatt et al, 1986;Lillie et al, 2011;Barnett et al, 2012;Parker and Vannest, 2012;Dallery et al, 2013;Duan et al, 2013;Kravitz and Duan, 2014;Schork, 2015;Strathmann, 2015;Vohra et al, 2015;De Groot and Martin-Sanchez, 2017;Lobo et al, 2017;Mirza et al, 2017). The U.S. Department of Health's Agency for Healthcare Research and Quality has even published its own user guide to N-of-1 trials (AHRQ, 2014), and CONSORT has issued reporting guidelines (Vohra et al, 2015).…”