2018
DOI: 10.1016/j.pvr.2018.10.001
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Single type infection of human papillomavirus as a cause for high-grade cervical intraepithelial neoplasia and invasive cancer in Japan

Abstract: To elucidate oncogenic human papilloma virus (HPV) types in Japan, HPV genotyping was performed in 1526 cervical intraepithelial neoplasia (CIN) and 371 invasive cervical cancer (ICC) patients with the novel Genosearch-31+5 HPV test. The HPV-positive rates were 89.3% and 90.8% in CIN and ICC. Regarding single-type infections, 13 internationally recognized high-risk (13HR) types excluding HPV 35, and probably HR HPV 53, 67, 69, and 70 were identified in ICC, suggesting that all these types may be oncogenic. HPV… Show more

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Cited by 36 publications
(60 citation statements)
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“…Although in this study we used data of L1 HPV-45 sequence only from cervical Epitopes Isolate Amino Acid Chain Sequence Amino Acid Sequence Epitope 1 (non-surface exposed) cancer isolates (Table 1), and cannot compare the stage of cervical neoplasia, our finding could support previous study which found that lineage B2 is associated with higher risk of cervical cancer Chen et al, 2014). Interestingly, from histopathological data, four out of five samples are diagnosed as squamous cell carcinoma of cervix (Table 1), whereas HPV 45 are known to predominant in cervical adenocarcinoma (Quint et al, 2009;Sakamoto et al, 2018). Nevertheless, further research with more HPV-45 samples are needed to confirm this finding.…”
Section: Hpv 45 Variant Lineagessupporting
confidence: 80%
“…Although in this study we used data of L1 HPV-45 sequence only from cervical Epitopes Isolate Amino Acid Chain Sequence Amino Acid Sequence Epitope 1 (non-surface exposed) cancer isolates (Table 1), and cannot compare the stage of cervical neoplasia, our finding could support previous study which found that lineage B2 is associated with higher risk of cervical cancer Chen et al, 2014). Interestingly, from histopathological data, four out of five samples are diagnosed as squamous cell carcinoma of cervix (Table 1), whereas HPV 45 are known to predominant in cervical adenocarcinoma (Quint et al, 2009;Sakamoto et al, 2018). Nevertheless, further research with more HPV-45 samples are needed to confirm this finding.…”
Section: Hpv 45 Variant Lineagessupporting
confidence: 80%
“…In a recent report using LA data from the MINT study I, the genotype-specific risks of disease progression may have been slightly overestimated for HPV52 because these risks were calculated from prevalence ratios between CIN2-3/AIS/ICC and CIN1 (Onuki et al 2020). Given that HPV52 prevalence is relatively high in patients with ICC (7.0-11.8%) and CIN2-3 (13.9-26.5%) in Japan (Miura et al 2006;Onuki et al 2009;Azuma et al 2014;Sakamoto et al 2018), accurate detection of HPV52 is important for vaccine surveillance. The 9-valent vaccine is reported to confer approximately 96% protection against HPV31/33/45/52/58 persistent infections and associated diseases (Joura et al 2015), and has been approved for use in Japan in 2020.…”
Section: Discussionmentioning
confidence: 99%
“…These types may be more common in East Asia than in Western and African countries . Another explanation for these differences may be the use of different HPV detection methods …”
Section: Discussionmentioning
confidence: 99%
“…Other types, such as HPV26, 53, 66, 67, 70, 73, and 82, are rare but have been identified in cervical cancer. These rare types might have some carcinogenic potential . Among these HPV types, HPV53, 67, 70, and 82 have been identified in cervical cancer in Japan …”
Section: Introductionmentioning
confidence: 99%
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