2024
DOI: 10.1101/2024.01.27.577601
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Single-use, Metabolite Absorbing, Resonant Transducer (SMART) culture vessels for label-free, continuous cell culture progression monitoring

Yee Jher Chan,
Dhananjay Dileep,
Samuel M. Rothstein
et al.

Abstract: Secreted metabolites are an important class of bio-process analytical technology (PAT) targets that can correlate to cell condition. However, current strategies for measuring metabolites are limited to discrete measurements, resulting in limited understanding and ability for feedback control strategies. Herein, we demonstrated a continuous metabolite monitoring strategy using a single-use metabolite absorbing resonant transducer (SMART) to correlate with cell growth. Polyacrylate was shown to absorb secreted m… Show more

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